A Study to Evaluate Mezigdomide, Bortezomib and Dexamethasone (MEZIVd) Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)

Part of paid clinical trials in Los Alamitos, California.

Sponsor
Celgene
Study ID
NCT05519085
Phase
PHASE3
Status
Recruiting
Apply to this trial

Conditions

  • Relapsed or Refractory Multiple Myeloma

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • mezigdomide — DRUG
    Specified dose on specified days
  • Pomalidomide — DRUG
    Specified dose on specified days
  • Bortezomib — DRUG
    Specified dose on specified days
  • Dexamethasone — DRUG
    Specified dose on specified days

Study Details

The purpose of this study is to compare the efficacy and safety of mezigdomide (CC-92480), bortezomib and dexamethasone (MeziVd) versus pomalidomide, bortezomib and dexamethasone (PVd) in participants with relapsed or refractory multiple myeloma (RRMM) who received between 1 to 3 prior lines of therapy and who have had prior lenalidomide exposure.

Key Dates

Start date
Sep 20, 2022
Status verified
Jun 2026
Primary completion
Jan 10, 2027
Completion
Nov 30, 2033

Study Design

Enrollment
810 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: MeziVd (mezigdomide, bortezomib and dexamethasone)
  • Experimental: PVd (pomalidomide, bortezomib and dexamethasone)

Primary Outcome Measure

Progression-free Survival (PFS) [ Time Frame: From date of randomization to date of disease progression or death due to any cause (Up to approximately 5 years) ]

Central Contacts

  • BMS Clinical Trials Contact Center www.BMSClinicalTrials.com
    855-907-3286
    [email protected]
  • First line of the email MUST contain NCT # and Site #.

Locations (56)

FacilityCityStateZIPSite coordinators
Local Institution - 0366Los AlamitosCalifornia90720-
Local Institution - 0272San DiegoCalifornia92123-
Local Institution - 0273West HollywoodCalifornia90069-
Local Institution - 0381AuroraColorado80045
Site 0381
Local Institution - 0380FarmingtonConnecticut06030-
Local Institution - 0208New HavenConnecticut06510-
Local Institution - 0303Coral SpringsFlorida33321-
Local Institution - 0403Fort MyersFlorida33901-
Local Institution - 0401St. PetersburgFlorida33701-
Local Institution - 0402West Palm BeachFlorida33401-
Local Institution - 0211AthensGeorgia30607-
Local Institution - 0048MariettaGeorgia30060-
Local Institution - 0330Garden CityKansas67846-
Local Institution - 0080WestwoodKansas66205-
Local Institution - 0358Baton RougeLouisiana70808-
Local Institution - 0255New OrleansLouisiana70112-
Local Institution - 0385ShreveportLouisiana71103
Site 0385
Local Institution - 0357BaltimoreMaryland21215-
Local Institution - 0246BostonMassachusetts02215-
Local Institution - 0271Ann ArborMichigan48109-
Local Institution - 0364DetroitMichigan48202-
Local Institution - 0410MinneapolisMinnesota55404-
Local Institution - 0088HattiesburgMississippi39401-
Local Institution - 0242JacksonMississippi39213-
Local Institution - 0288East BrunswickNew Jersey08816-
Local Institution - 0363RidgewoodNew Jersey07450
Site 0363
Local Institution - 0302AlbuquerqueNew Mexico87131-
Local Institution - 0245BuffaloNew York14215-
Local Institution - 0257Lake SuccessNew York11042-
Local Institution - 0373New Hyde ParkNew York11042-
Local Institution - 0371New YorkNew York10028-
Local Institution - 0108RochesterNew York14621-
Local Institution - 0374ShirleyNew York11967-
Local Institution - 0372The BronxNew York10469-
Local Institution - 0274WilliamsvilleNew York14221-
Local Institution - 0260DurhamNorth Carolina27710-
Local Institution - 0400CincinnatiOhio45242-
Local Institution - 0076ClevelandOhio44195-
Local Institution - 0377ClevelandOhio44111-
Local Institution - 0376Mayfield HeightsOhio44124-
Local Institution - 0359AllentownPennsylvania18103-
Local Institution - 0264YorkPennsylvania17403-
Local Institution - 0223GermantownTennessee38138-
Local Institution - 0378AbileneTexas79606-
Local Institution - 0275HoustonTexas77030-
Local Institution - 0267San AntonioTexas78229-
Local Institution - 0409San AntonioTexas78240-
Local Institution - 0207Salt Lake CityUtah84106-
Local Institution - 0297FredericksburgVirginia22408-
Local Institution - 0408NorfolkVirginia23502-
Local Institution - 0399RoanokeVirginia24014-
Local Institution - 0268SeattleWashington98108-
Local Institution - 0293SeattleWashington98109-
Local Institution - 0097SpokaneWashington99208-
Local Institution - 0411VancouverWashington98684-
Local Institution - 0220MadisonWisconsin53792-

Find similar trials in Los Alamitos, CA

By research site
Local Institution - 0366· Los Alamitos, CALocal Institution - 0272· San Diego, CALocal Institution - 0273· West Hollywood, CALocal Institution - 0381· Aurora, COLocal Institution - 0380· Farmington, CTLocal Institution - 0208· New Haven, CT

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