Carisbamate Clinical Trials (2026): 13 Studies for Epilepsy, Complex Partial & Lennox Gastaut Syndrome

Hipa.ai Research · Source: ClinicalTrials.gov / AACT

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13 Carisbamate clinical trials are catalogued on Hipa.ai from the AACT mirror of ClinicalTrials.gov, spanning 10 indications (including Epilepsy, Complex Partial & Lennox Gastaut Syndrome) and 3,030 total planned enrollment. 5 Phase 3 Carisbamate trials and 4 Phase 2 are listed. 1 Carisbamate clinical trial is actively recruiting at 7 U.S. sites across 6 states. Most recent activity: NCT05219617 (Dec 2028).

Where to Participate: All Carisbamate Trial Sites in the U.S. (7 sites across 6 states)

Every actively recruiting Carisbamatetrial site, sorted by state then city. Each row links to the trial detail page (eligibility, contacts, full study record). Sites no longer enrolling at the location level are excluded. ClinicalTrials.gov / AACT does not provide street-level addresses; the map link uses the facility's geocoded coordinates where available.

StateFacilityCityTrialMap
CAStanford University HospitalPalo Alto94305NCT05219617Map
FLPediatric Epilepsy and Neurology SpecialistsTampa33609NCT05219617Map
MDJohns Hopkins HospitalBaltimore21287NCT05219617Map
MDMid-Atlantic Epilepsy and Sleep CenterBethesda20817NCT05219617Map
NJNortheast Regional Epilepsy GroupHackensack07601NCT05219617Map
NCDuke University Clinical Research at Pickett RoadDurham27713NCT05219617Map
PAChildren's Hospital of PhiladelphiaPhiladelphia19104NCT05219617Map

Carisbamate clinical trials at a glance: phase × recruitment status

PhaserecruitingcompletedterminatedTotal
P133
P1/P211
P244
P31315

Recruiting Carisbamate clinical trials (1)

Studies currently enrolling participants. Click any NCT ID to view the trial detail page (eligibility, sites, contacts).

NCT IDTitlePhaseIndicationEnrollmentStarted
NCT05219617Investigate Efficacy and Safety of Carisbamate as Adjunctive Treatment for Seizures Associated With LGS in Children and AdultsP3Seizures252Apr 2022

Carisbamate clinical trials by indication

Lennox Gastaut Syndrome (2)

NCTAcronymPhaseStatusTitle
NCT04062981P1completedCarisbamate Safety Study in Adult and Pediatric Subjects With Lennox-Gastaut Syndrome
NCT03731715P1completedCarisbamate in Adult & Pediatric Subjects With Lennox-Gastaut Syndrome

Epilepsy, Partial, Motor (2)

NCTAcronymPhaseStatusTitle
NCT00744731P3completedAn Open-Label Extension Study of the Safety and Tolerability of Carisbamate as Add-On Therapy in Patients With Partial Onset Seizures
NCT00740623P3completedA Study of the Effectiveness, Safety, and Tolerability of Carisbamate as Add-On Therapy in Patients With Partial Onset Seizures.

Epilepsy (2)

NCTAcronymPhaseStatusTitle
NCT00991757P3completedAn Open-Label Extension Study to Evaluate the Safety and Tolerability of RWJ 333369 as Adjunctive Therapy in Patients 16 Years and Older With Partial Onset Seizures.
NCT00563459P3terminatedCarisbamate Retention Study (CaReS): Comparative Study on the Long Term Effectiveness, Safety and Tolerability of Carisbamate Compared to Two Other Frequently Prescribed Anti-epileptic Drugs (AEDs) in Patients With Epilepsy.

Seizures (1)

NCTAcronymPhaseStatusTitle
NCT05219617P3recruitingInvestigate Efficacy and Safety of Carisbamate as Adjunctive Treatment for Seizures Associated With LGS in Children and Adults

Healthy Subjects (1)

NCTAcronymPhaseStatusTitle
NCT04520360P1completedBioavailability and Food Effect Study of 3 Types of Carisbamate

Alcohol Dependence (1)

NCTAcronymPhaseStatusTitle
NCT02435381P1/P2completedCarisbamate as a Potential Treatment for Alcohol Dependence

Diabetic Neuropathies (1)

NCTAcronymPhaseStatusTitle
NCT00870454P2completedAn Efficacy and Safety Study of Carisbamate in the Treatment of Nerve Pain in Diabetics

Essential Tremor, Movement Disorders (1)

NCTAcronymPhaseStatusTitle
NCT00524056P2completedA Proof of Concept Study of the Effectiveness of Carisbamate in the Treatment of Essential Tremor

Diabetic Neuropathy, Painful (1)

NCTAcronymPhaseStatusTitle
NCT00501202DPNP2completedStudy for Safety and Effectiveness of RWJ-333369 (Carsibamate) for the Treatment of Diabetic Peripheral Neuropathy (DPN).

Postherpetic Neuralgia (1)

NCTAcronymPhaseStatusTitle
NCT00492323PHNP2completedAn Effectiveness and Safety Study With RWJ-333369 (Carisbamate) for the Study of Postherpetic Neuralgia (PHN).

Carisbamate pivotal trial highlights (Phase 2/3/4)

Phase-2/3/4 studies with named acronyms — the registration-grade trials most cited in label discussions and Wikipedia.

AcronymNCTPhaseStatusIndicationEnrollmentPubMed
PHNNCT00492323P2completedPostherpetic Neuralgia91
DPNNCT00501202P2completedDiabetic Neuropathy, Painful132

Terminated and withdrawn Carisbamate trials (1)

Studies that ended before completion. Reasons are filed in each trial's ClinicalTrials.gov entry.

All Carisbamate trials (13)

Sorted by most recent activity (completion → start → posted date). Each row links to the trial detail page on Hipa.ai.

NCT IDAcronymTitlePhaseStatusEnrollmentSponsorStarted
NCT05219617Investigate Efficacy and Safety of Carisbamate as Adjunctive Treatment for Seizures Associated With LGS in Children and AdultsP3recruiting252SK Life Science, Inc.Apr 2022
NCT04062981Carisbamate Safety Study in Adult and Pediatric Subjects With Lennox-Gastaut SyndromeP1completed15SK Life Science, Inc.May 2019
NCT03731715Carisbamate in Adult & Pediatric Subjects With Lennox-Gastaut SyndromeP1completed18SK Life Science, Inc.Feb 2019
NCT04520360Bioavailability and Food Effect Study of 3 Types of CarisbamateP1completed33SK Life Science, Inc.Aug 2020
NCT02435381Carisbamate as a Potential Treatment for Alcohol DependenceP1/P2completed11Baylor College of MedicineFeb 2013
NCT00870454An Efficacy and Safety Study of Carisbamate in the Treatment of Nerve Pain in DiabeticsP2completed386SK Life Science, Inc.May 2009
NCT00991757An Open-Label Extension Study to Evaluate the Safety and Tolerability of RWJ 333369 as Adjunctive Therapy in Patients 16 Years and Older With Partial Onset Seizures.P3completed991SK Life Science, Inc.Feb 2007
NCT00744731An Open-Label Extension Study of the Safety and Tolerability of Carisbamate as Add-On Therapy in Patients With Partial Onset SeizuresP3completed403SK Life Science, Inc.Jan 2009
NCT00740623A Study of the Effectiveness, Safety, and Tolerability of Carisbamate as Add-On Therapy in Patients With Partial Onset Seizures.P3completed547SK Life Science, Inc.Jan 2009
NCT00563459Carisbamate Retention Study (CaReS): Comparative Study on the Long Term Effectiveness, Safety and Tolerability of Carisbamate Compared to Two Other Frequently Prescribed Anti-epileptic Drugs (AEDs) in Patients With Epilepsy.P3terminated89SK Life Science, Inc.Nov 2007
NCT00492323PHNAn Effectiveness and Safety Study With RWJ-333369 (Carisbamate) for the Study of Postherpetic Neuralgia (PHN).P2completed91SK Life Science, Inc.Mar 2007
NCT00501202DPNStudy for Safety and Effectiveness of RWJ-333369 (Carsibamate) for the Treatment of Diabetic Peripheral Neuropathy (DPN).P2completed132SK Life Science, Inc.Mar 2007
NCT00524056A Proof of Concept Study of the Effectiveness of Carisbamate in the Treatment of Essential TremorP2completed62SK Life Science, Inc.Aug 2007

Carisbamate clinical trials: frequently asked questions

How many Carisbamate clinical trials are there?
13 Carisbamate clinical trials are catalogued on Hipa.ai, sourced from the AACT mirror of ClinicalTrials.gov. 1 is actively recruiting participants. 11 are marked completed.
Are Carisbamate clinical trials recruiting in 2026?
Yes — 1 Carisbamate trial is actively recruiting in 2026, with 7 U.S. sites across 6 states. See the recruiting trials and the per-state site list further down this page.
What conditions is Carisbamate being studied for?
Carisbamate is being studied for Epilepsy, Complex Partial, Lennox Gastaut Syndrome, Epilepsy, Seizures, Focal Motor Epilepsy and 17 more. The trials are grouped by indication on this page.
What phase is Carisbamate in?
Carisbamate clinical trials span 5 Phase 3, 4 Phase 2, 3 Phase 1. The phase × status matrix at the top of this page breaks down counts by phase and recruitment status.
Who sponsors Carisbamate clinical trials?
The lead sponsor across the most Carisbamate trials is SK Life Science, Inc., with 1 additional lead sponsor listed in the data. Each trial row links to the full study detail page including sponsor information.

Sources and methodology

Trial inventory derived from the AACT mirror of ClinicalTrials.gov. Trials are filtered to those naming Carisbamateas an intervention. Phase, status, enrollment, sponsor, and dates are taken from the source `studies` table; primary indication is the first listed condition. Acronyms are extracted from each trial's brief title where present. PubMed links are populated for trials whose published primary outcomes have been indexed in our evidence cache.

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