Belantamab mafodotin Clinical Trials (2026): 69 Studies for Multiple Myeloma & Refractory Multiple Myeloma

Hipa.ai Research · Source: ClinicalTrials.gov / AACT

Synced daily from ClinicalTrials.gov via AACT. Last sync: .

69 Belantamab mafodotin clinical trials are catalogued on Hipa.ai from the AACT mirror of ClinicalTrials.gov, spanning 19 indications (including Multiple Myeloma & Refractory Multiple Myeloma) and 6,011 total planned enrollment. 10 Phase 3 Belantamab mafodotin trials and 18 Phase 2 are listed. 21 Belantamab mafodotin clinical trials are actively recruiting at 93 U.S. sites across 29 states. Most recent activity: NCT07285239 (Jun 2034).

Where to Participate: All Belantamab mafodotin Trial Sites in the U.S. (93 sites across 29 states)

Every actively recruiting Belantamab mafodotintrial site, sorted by state then city. Each row links to the trial detail page (eligibility, contacts, full study record). Sites no longer enrolling at the location level are excluded. ClinicalTrials.gov / AACT does not provide street-level addresses; the map link uses the facility's geocoded coordinates where available.

StateFacilityCityTrialMap
ALGSK Investigational SiteMobile36607NCT06679101Map
AZGSK Investigational SitePhoenix85054NCT06679101Map
CAGSK Investigational SiteBeverly Hills90211NCT06679101Map
CAGSK Investigational SiteLos Alamitos90720NCT07227311Map
CAGSK Investigational SitePasadena91105NCT06679101Map
CAGSK Investigational SiteTorrance90505NCT07227311Map
CAGSK Investigational SiteWhittier90602NCT07227311Map
COGSK Investigational SiteAurora80012NCT06679101Map
DCGSK Investigational SiteWashington D.C.20007NCT06679101Map
FLGSK Investigational SiteEnglewood34223NCT06679101Map
FLGSK Investigational SiteFort Myers33912NCT07227311Map
FLMayo Clinic in FloridaJacksonville32224-9980NCT05847569Map
FLGSK Investigational SiteLady Lake32159NCT06679101Map
FLGSK Investigational SitePembroke Pines33024NCT06679101Map
FLGSK Investigational SiteSaint Augustine32256NCT06679101Map
GAEmory University/Winship Cancer InstituteAtlanta30322NCT05208307Map
GAGSK Investigational SiteAtlanta30322NCT06679101Map
GAWinship Cancer Institute of Emory University- Site Number : 8400010Atlanta30322NCT04643002Map
GAGSK Investigational SiteMacon31210NCT07227311Map
ILUniversity of Chicago Medicine Comprehensive Cancer CenterChicago60637NCT05789303Map
IAMary Greeley Medical CenterAmes50010NCT06232044Map
IAMcFarland Clinic - AmesAmes50010NCT06232044Map
IAMcFarland Clinic - Trinity Cancer CenterFort Dodge50501NCT06232044Map
IAMcFarland Clinic - MarshalltownMarshalltown50158NCT06232044Map
MEGSK Investigational SitePortland04074NCT06679101Map
MDGSK Investigational SiteBethesda20817NCT07227311Map
MADana-Farber Cancer InstituteBoston02215NCT05922501Map
MADana-Farber Cancer InstituteBoston02215NCT06232044Map
MAMassachusetts General HospitalBoston02114NCT05922501Map
MATufts Medical CenterBoston02111NCT06232044Map
MAGSK Investigational SiteWorcester01655NCT06679101Map
MIGSK Investigational SiteAnn Arbor48103NCT06679101Map
MIUniversity of Michigan Health System - Ann Arbor- Site Number : 8400004Ann Arbor48109NCT04643002Map
MIGSK Investigational SiteDetroit48201NCT06679101Map
MIGSK Investigational SiteGrand Rapids49546NCT05714839Map
MNCoborn Cancer Center at Saint Cloud HospitalSaint Cloud56303NCT06232044Map
MOGSK Investigational SiteBridgeton63044NCT07227311Map
MOGSK Investigational SiteSpringfield65807NCT07227311Map
MTGSK Investigational SiteBillings59102NCT06679101Map
NJGSK Investigational SiteHackensack07601NCT06679101Map
NJMemorial Sloan Kettering MonmouthMiddletown07748NCT06232044Map
NJMemorial Sloan Kettering BergenMontvale07645NCT06232044Map
NMGSK Investigational SiteFarmington87401NCT07227311Map
NYRoswell Park Cancer Institute- Site Number : 8400008Buffalo14263NCT04643002Map
NYMemorial Sloan Kettering CommackCommack11725NCT06232044Map
NYMemorial Sloan Kettering WestchesterHarrison10604NCT06232044Map
NYGSK Investigational SiteNew York10065NCT06679101Map
NYMemorial Sloan Kettering Cancer CenterNew York10065NCT06232044Map
NYGSK Investigational SiteStony Brook11790NCT06679101Map
NCGSK Investigational SiteChapel Hill27514NCT05714839Map
NCGSK Investigational SiteCharlotte28204NCT06679101Map
NCGSK Investigational SiteWinston-Salem27103NCT06679101Map
OHOhioHealth O'Bleness HospitalAthens45701NCT06232044Map
OHColumbus Oncology and Hematology Associates IncColumbus43214NCT06232044Map
OHDoctors HospitalColumbus43228NCT06232044Map
OHGrant Medical CenterColumbus43215NCT06232044Map
OHGSK Investigational SiteColumbus43214NCT06679101Map
OHRiverside Methodist HospitalColumbus43214NCT06232044Map
OHThe Ohio State University- Site Number : 8400012Columbus43210NCT04643002Map
OHDelaware Health Center-Grady Cancer CenterDelaware43015NCT06232044Map
OHGrady Memorial HospitalDelaware43015NCT06232044Map
OHColumbus Oncology and Hematology AssociatesDublin43016NCT06232044Map
OHDublin Methodist HospitalDublin43016NCT06232044Map
OHOhioHealth Mansfield HospitalMansfield44903NCT06232044Map
OHOhioHealth Marion General HospitalMarion43302NCT06232044Map
OHOhioHealth Pickerington Methodist HospitalPickerington43147NCT06232044Map
OHOhioHealth Westerville Medical Campus/Westerville Cancer CenterWesterville43082NCT06232044Map
OKUniversity of Oklahoma Health Sciences CenterOklahoma City73104NCT06232044Map
RIGSK Investigational SiteProvidence02903NCT06679101Map
TNGSK Investigational SiteChattanooga37404NCT05714839Map
TNGSK Investigational SiteNashville37203NCT05714839Map
TNVanderbilt University/Ingram Cancer CenterNashville37232NCT06232044Map
TXGSK Investigational SiteAustin78705NCT06679101Map
TXGSK Investigational SiteAustin78712NCT06679101Map
TXUT Southwestern Medical CenterDallas75390NCT05145816Map
TXM D Anderson Cancer CenterHouston77030NCT05055063Map
TXMD Anderson Cancer CenterHouston77051NCT05091372Map
TXGSK Investigational SiteKingwood77339NCT06679101Map
TXGSK Investigational SiteSan Antonio78240NCT06679101Map
TXGSK Investigational SiteTyler75702NCT06679101Map
UTHuntsman Cancer Institute/University of UtahSalt Lake City84112NCT06232044Map
VAGSK Investigational SiteFairfax22031NCT06679101Map
WAGSK Investigational SitePuyallup98373NCT06679101Map
WISaint Vincent Hospital Cancer Center at Saint Mary'sGreen Bay54303NCT06232044Map
WISaint Vincent Hospital Cancer Center Green BayGreen Bay54301NCT06232044Map
WIMedical College of WisconsinMilwaukee53226NCT06232044Map
WIProHealth D N Greenwald CenterMukwonago53149NCT06232044Map
WIProHealth Oconomowoc Memorial HospitalOconomowoc53066NCT06232044Map
WISaint Vincent Hospital Cancer Center at SheboyganSheboygan53081NCT06232044Map
WISheboygan Physicians GroupSheboygan53081NCT06232044Map
WISaint Vincent Hospital Cancer Center at Sturgeon BaySturgeon Bay54235-1495NCT06232044Map
WIProHealth Waukesha Memorial HospitalWaukesha53188NCT06232044Map
WIUW Cancer Center at ProHealth CareWaukesha53188NCT06232044Map

Belantamab mafodotin clinical trials at a glance: phase × recruitment status

Phaserecruitingactive not recruitingcompletedterminatedwithdrawnnot yet recruitingunknownavailableTotal
P113222111
P1/P26113311126
P26332418
P31611110
N/A11114

Recruiting Belantamab mafodotin clinical trials (21)

Studies currently enrolling participants. Click any NCT ID to view the trial detail page (eligibility, sites, contacts).

NCT IDTitlePhaseIndicationEnrollmentStarted
NCT07285239PrE1005Belantamab Mafodotin or Daratumumab With Bortezomib, Lenalidomide and Dexamethasone for Newly Diagnosed Multiple MyelomaP3Multiple Myeloma500Jul 2026
NCT05847569Alternate Doses and Dosing Schedules of Belantamab Mafodotin for Treatment of Triple-Class Refractory Multiple MyelomaP2Recurrent Multiple Myeloma62Jan 2024
NCT07224672ALANISA Study to Evaluate the Efficacy and Safety of Belantamab Mafodotin in Combination With Cyclophosphamide, Bortezomib, and Dexamethasone in Adult Participants With Newly Diagnosed Amyloid Light Chain (AL) AmyloidosisP2Amyloidosis60Mar 2026
NCT07609706A Study of the Combination of Belantamab Mafodotin, Bortezomib, and Dexamethasone (BVd) in Participants With Multiple Myeloma and Moderate Hepatic ImpairmentP1Multiple Myeloma20Oct 2026
NCT06679101DREAMM-10A Study of Belantamab Mafodotin Administered in Combination With Lenalidomide and Dexamethasone (BRd) Versus Daratumumab, Lenalidomide, and Dexamethasone (DRd) in Participants With Newly Diagnosed Multiple Myeloma (NDMM) Who Are Ineligible for Autologous Stem Cell Transplantation (TI-NDMM)P3Multiple Myeloma520Dec 2024
NCT07614360DREAMM-16Study of Alternative and Approved Dosing Regimens of Belantamab Mafodotin, Bortezomib, and Dexamethasone (BVd) in Participants With Relapsed/Refractory Multiple MyelomaP2Multiple Myeloma120Aug 2026
NCT05922501ISABELAIsatuximab, Bela Maf, Pom, and Dex in Relapsed/Refractory Multiple MyelomaP2Relapsed Cancer50May 2024
NCT07227311RRMMA Study to Evaluate the Efficacy and Safety of Belantamab Mafodotin in Combination With Standard of Care in Participants With Relapsed-Refractory Multiple Myeloma (RRMM)P2Multiple Myeloma200Apr 2026
NCT06232044Testing the Combination of Two Approved Drugs and One Experimental Drug in Patients With Relapsed or Refractory Multiple MyelomaP1/P2Recurrent Multiple Myeloma88Apr 2025
NCT05714839DREAMM-20A Study to Investigate the Safety and Efficacy of Belantamab for the Treatment of Multiple Myeloma When Used as Monotherapy and in Combination TreatmentsP1/P2Multiple Myeloma152Jun 2023
NCT05853965BELI(E)VECombination Treatment of Belantamab Mafodotin and Venetoclax in Treatment of Relapsed and Refractory t(11;14) Multiple MyelomaP1/P2Multiple Myeloma45Jun 2023
NCT05789303Study of Belantamab Mafodotin With Carfilzomib, Pomalidomide, and Dexamethasone in Relapsed Multiple MyelomaP2Multiple Myeloma83May 2023
NCT05874193COSTAA Collaborative Community Effort Using Belantamab Mafodotin in Relapsed/Refractory MyelomaP2Relapsed/Refractory Multiple Myeloma33May 2026
NCT04643002Isatuximab in Combination With Novel Agents in RRMM - Master ProtocolP1/P2Plasma Cell Myeloma Refractory258Jan 2021
NCT05091372Minimal Residual Disease Guided Maintenance Therapy With Belantamab Mafodotin and Lenalidomide After Autologous Hematopoietic Cell Transplantation in Patients With Newly Diagnosed Multiple MyelomaP2Myeloma Multiple94Dec 2022
NCT05208307Belantamab Mafodotin, Pomalidomide and Dexamethasone for the Treatment of High-Risk MyelomaP2Plasma Cell Myeloma34Jul 2022
NCT05145816Phase 1/2a Study of Belantamab Mafodotin in Relapsed or Refractory AL AmyloidosisP1/P2AL Amyloidosis37Feb 2024
NCT07019545BONSAIA PHASE II TRIAL AIMING TO INVESTIGATE THE SAFETY AND CLINICAL ACTIVITY OF BELANTAMAB MAFODOTIN IN ADULT PATIENTS WITH PRIMARY IMMUNE THROMBOCYTOPENIA PREVIOUSLY TREATED WITH A THROMBOPOIETIN RECEPTOR AGONIST AND/OR RITUXIMAB AFTER CORTICOSTEROID FIRST-LINE THERAPYP2Primary Immune Thrombocytopenia (ITP)14Jun 2025
NCT05055063A Phase 1 With Extension Cohort, Single Arm, Single Center, Open Label Trial of Belantamab Mafodotin for the Treatment of High-Risk Smoldering Multiple MyelomaP1Myeloma30May 2022
NCT05573802A Study to Investigate Safety and Clinical Activity of Belantamab Mafodotin in Combination With Lenalidomide, Dexamethasone and Nirogacestat in Patients With Transplant Ineligible Newly Diagnosed Multiple MyelomaP1/P2Multiple Myeloma36Jul 2023
NCT05581875A Study to Investigate the Safety and Clinical Activity of Belantamab Mafodotin in Combination With Daratumumab, Pomalidomide and Dexamethasone in Patients With Relapsed/ Refractory Multiple Myeloma Previously Treated With One Line Therapy Who Are Lenalidomide RefractoryP1/P2Multiple Myeloma48Oct 2022

Belantamab mafodotin clinical trials by indication

Multiple Myeloma (43)

NCTAcronymPhaseStatusTitle
NCT07285239PrE1005P3not yet recruitingBelantamab Mafodotin or Daratumumab With Bortezomib, Lenalidomide and Dexamethasone for Newly Diagnosed Multiple Myeloma
NCT04822337P1/P2active not recruitingStudy of Carfilzomib, Lenalidomide, Dexamethasone and Belantamab Mafodotin in Multiple Myeloma
NCT07609706P1not yet recruitingA Study of the Combination of Belantamab Mafodotin, Bortezomib, and Dexamethasone (BVd) in Participants With Multiple Myeloma and Moderate Hepatic Impairment
NCT06679101DREAMM-10P3recruitingA Study of Belantamab Mafodotin Administered in Combination With Lenalidomide and Dexamethasone (BRd) Versus Daratumumab, Lenalidomide, and Dexamethasone (DRd) in Participants With Newly Diagnosed Multiple Myeloma (NDMM) Who Are Ineligible for Autologous Stem Cell Transplantation (TI-NDMM)
NCT07614360DREAMM-16P2not yet recruitingStudy of Alternative and Approved Dosing Regimens of Belantamab Mafodotin, Bortezomib, and Dexamethasone (BVd) in Participants With Relapsed/Refractory Multiple Myeloma
NCT07227311RRMMP2recruitingA Study to Evaluate the Efficacy and Safety of Belantamab Mafodotin in Combination With Standard of Care in Participants With Relapsed-Refractory Multiple Myeloma (RRMM)
NCT05714839DREAMM-20P1/P2recruitingA Study to Investigate the Safety and Efficacy of Belantamab for the Treatment of Multiple Myeloma When Used as Monotherapy and in Combination Treatments
NCT06956170DREAMM 8P3active not recruitingAll Japanese Population: Belantamab Mafodotin Plus Pomalidomide and Dexamethasone (Pd) Versus Bortezomib Plus Pd in Relapsed/Refractory Multiple Myeloma
+ 35 more, see All trials below.

Relapsed/Refractory Multiple Myeloma (4)

NCTAcronymPhaseStatusTitle
NCT05874193COSTAP2not yet recruitingA Collaborative Community Effort Using Belantamab Mafodotin in Relapsed/Refractory Myeloma
NCT04896658P1/P2terminatedBelantamab Mafodotin, Cyclophosphamide, and Dexamethasone in Relapsed/Refractory Multiple Myeloma
NCT06655818GSK2857916P1/P2terminatedSub-study of Belantamab Mafodotin (GSK2857916) as Monotherapy and in Combination With Dostarlimab (GSK4057190) in Participants With RRMM
NCT06160609GSK2857916P1/P2terminatedPlatform Sub-study of Belantamab Mafodotin (GSK2857916) in Combination With aOX40 (GSK3174998) in Participants With RRMM

Plasma Cell Myeloma (3)

NCTAcronymPhaseStatusTitle
NCT05208307P2recruitingBelantamab Mafodotin, Pomalidomide and Dexamethasone for the Treatment of High-Risk Myeloma
NCT04876248P2active not recruitingBelantamab Mafodotin and Lenalidomide for the Treatment of Multiple Myeloma in Patients With Minimal Residual Disease Positive After Stem Cell Transplant
NCT04892264P1terminatedBelantamab Mafodotin, Lenalidomide, and Daratumumab for the Treatment of Relapsed, Refractory, or Previously Untreated Multiple Myeloma

Recurrent Multiple Myeloma (2)

NCTAcronymPhaseStatusTitle
NCT05847569P2recruitingAlternate Doses and Dosing Schedules of Belantamab Mafodotin for Treatment of Triple-Class Refractory Multiple Myeloma
NCT06232044P1/P2recruitingTesting the Combination of Two Approved Drugs and One Experimental Drug in Patients With Relapsed or Refractory Multiple Myeloma

AL Amyloidosis (2)

NCTAcronymPhaseStatusTitle
NCT05145816P1/P2recruitingPhase 1/2a Study of Belantamab Mafodotin in Relapsed or Refractory AL Amyloidosis
NCT04617925EMN27P2completedA Study of Belantamab Mafodotin in Patients With Relapsed or Refractory AL Amyloidosis

Myeloma (2)

NCTAcronymPhaseStatusTitle
NCT05055063P1recruitingA Phase 1 With Extension Cohort, Single Arm, Single Center, Open Label Trial of Belantamab Mafodotin for the Treatment of High-Risk Smoldering Multiple Myeloma
NCT04680468P2active not recruitingStudy of Belantamab Mafodotin as Pre- and Post-autologous Stem Cell Transplant and Maintenance for Multiple Myeloma

Amyloidosis (1)

NCTAcronymPhaseStatusTitle
NCT07224672ALANISP2not yet recruitingA Study to Evaluate the Efficacy and Safety of Belantamab Mafodotin in Combination With Cyclophosphamide, Bortezomib, and Dexamethasone in Adult Participants With Newly Diagnosed Amyloid Light Chain (AL) Amyloidosis

Primary Immune Thrombocytopenia (ITP) (1)

NCTAcronymPhaseStatusTitle
NCT07019545BONSAIP2not yet recruitingA PHASE II TRIAL AIMING TO INVESTIGATE THE SAFETY AND CLINICAL ACTIVITY OF BELANTAMAB MAFODOTIN IN ADULT PATIENTS WITH PRIMARY IMMUNE THROMBOCYTOPENIA PREVIOUSLY TREATED WITH A THROMBOPOIETIN RECEPTOR AGONIST AND/OR RITUXIMAB AFTER CORTICOSTEROID FIRST-LINE THERAPY

Autoimmune Diseases (1)

NCTAcronymPhaseStatusTitle
NCT06413511P1withdrawnA Study to Investigate the Safety and Pharmacological Effect of a Single Intravenous Infusion of Belantamab in Male and Female Participants Aged 18 to 75 With Autoimmune Disease

Relapsed Cancer (1)

NCTAcronymPhaseStatusTitle
NCT05922501ISABELAP2recruitingIsatuximab, Bela Maf, Pom, and Dex in Relapsed/Refractory Multiple Myeloma

Multiple Myeloma, Refractory (1)

NCTAcronymPhaseStatusTitle
NCT05493618P1/P2withdrawnPembrolizumab, Belantamab and Dexamethasone in Refractory Multiple Myeloma.

Myeloma Multiple (1)

NCTAcronymPhaseStatusTitle
NCT05091372P2recruitingMinimal Residual Disease Guided Maintenance Therapy With Belantamab Mafodotin and Lenalidomide After Autologous Hematopoietic Cell Transplantation in Patients With Newly Diagnosed Multiple Myeloma

Relapsed/ Refractory Multiple Myeloma (1)

NCTAcronymPhaseStatusTitle
NCT05461209MonumenTAL-5P3withdrawnA Study of Comparing Talquetamab to Belantamab Mafodotin in Participants With Relapsed/Refractory Multiple Myeloma

Refractory Multiple Myeloma (1)

NCTAcronymPhaseStatusTitle
NCT05117008EMBRACEP2terminatedMaintenance Belantamab Mafodotin (Blenrep®) After B-cell Maturation Antigen-Directed Chimeric Antigen Receptor T-cell Therapy in Patients With Relapsed and/or Refractory Multiple Myeloma

RELAPSED AND/OR REFRACTORY MULTIPLE MYELOMA (1)

NCTAcronymPhaseStatusTitle
NCT05297240RRMMN/AunknownRetrospective Study of the Use of Belantamab Mafodotin (Blenrep®) in Patients With Relapsed and/or Refractory Multiple Myeloma (RRMM) in Spain.

Relapsed Multiple Myeloma (1)

NCTAcronymPhaseStatusTitle
NCT05060627P1/P2active not recruitingStudy of Belantamab Mafodotin in Combination With Kd for the Treatment of Relapsed Myeloma Patients, Refractory to Lenalidomide

Relapsed Plasmablastic Lymphoma (1)

NCTAcronymPhaseStatusTitle
NCT04676360P2terminatedBelantamab Mafodotin In Plasmablastic Lymphoma & ALK+ Large B-Cell Lymphoma

Plasma Cell Myeloma Refractory (1)

NCTAcronymPhaseStatusTitle
NCT04643002P1/P2recruitingIsatuximab in Combination With Novel Agents in RRMM - Master Protocol

Relapsed Refractory Multiple Myeloma (1)

NCTAcronymPhaseStatusTitle
NCT03732703MyDRUGP1/P2completedMyeloma-Developing Regimens Using Genomics (MyDRUG)

Belantamab mafodotin pivotal trial highlights (Phase 2/3/4)

Phase-2/3/4 studies with named acronyms — the registration-grade trials most cited in label discussions and Wikipedia.

AcronymNCTPhaseStatusIndicationEnrollmentPubMed
PrE1005NCT07285239P3not yet recruitingMultiple Myeloma500
DREAMM-10NCT06679101P3recruitingMultiple Myeloma520
DREAMM 8NCT06956170P3active not recruitingMultiple Myeloma21
DREAMM 8NCT04484623P3active not recruitingMultiple Myeloma302PMID 40763276
DREAMM 7NCT06868654P3active not recruitingMultiple Myeloma72
DREAMM 7NCT06868667P3active not recruitingMultiple Myeloma24
DREAMM 7NCT04246047P3active not recruitingMultiple Myeloma494PMID 38828933
DREAMM-3NCT04162210P3active not recruitingMultiple Myeloma325PMID 37793771
MonumenTAL-5NCT05461209P3withdrawnRelapsed/ Refractory Multiple Myeloma0
ALANISNCT07224672P2not yet recruitingAmyloidosis60
DREAMM-16NCT07614360P2not yet recruitingMultiple Myeloma120
ISABELANCT05922501P2recruitingRelapsed Cancer50
RRMMNCT07227311P2recruitingMultiple Myeloma200
COSTANCT05874193P2not yet recruitingRelapsed/Refractory Multiple Myeloma33PMID 32265930
BONSAINCT07019545P2not yet recruitingPrimary Immune Thrombocytopenia (ITP)14
DREAMM 14NCT05064358P2completedMultiple Myeloma177
EMN27NCT04617925P2completedAL Amyloidosis35
EMBRACENCT05117008P2terminatedRefractory Multiple Myeloma1

Terminated and withdrawn Belantamab mafodotin trials (13)

Studies that ended before completion. Reasons are filed in each trial's ClinicalTrials.gov entry.

All Belantamab mafodotin trials (69)

Sorted by most recent activity (completion → start → posted date). Each row links to the trial detail page on Hipa.ai.

NCT IDAcronymTitlePhaseStatusEnrollmentSponsorStarted
NCT07285239PrE1005Belantamab Mafodotin or Daratumumab With Bortezomib, Lenalidomide and Dexamethasone for Newly Diagnosed Multiple MyelomaP3not yet recruiting500PrECOG, LLC.Jul 2026
NCT05847569Alternate Doses and Dosing Schedules of Belantamab Mafodotin for Treatment of Triple-Class Refractory Multiple MyelomaP2recruiting62Mayo ClinicJan 2024
NCT07224672ALANISA Study to Evaluate the Efficacy and Safety of Belantamab Mafodotin in Combination With Cyclophosphamide, Bortezomib, and Dexamethasone in Adult Participants With Newly Diagnosed Amyloid Light Chain (AL) AmyloidosisP2not yet recruiting60GlaxoSmithKlineMar 2026
NCT04822337Study of Carfilzomib, Lenalidomide, Dexamethasone and Belantamab Mafodotin in Multiple MyelomaP1/P2active not recruiting70Wake Forest University Health SciencesMay 2021
NCT07609706A Study of the Combination of Belantamab Mafodotin, Bortezomib, and Dexamethasone (BVd) in Participants With Multiple Myeloma and Moderate Hepatic ImpairmentP1not yet recruiting20GlaxoSmithKlineOct 2026
NCT06679101DREAMM-10A Study of Belantamab Mafodotin Administered in Combination With Lenalidomide and Dexamethasone (BRd) Versus Daratumumab, Lenalidomide, and Dexamethasone (DRd) in Participants With Newly Diagnosed Multiple Myeloma (NDMM) Who Are Ineligible for Autologous Stem Cell Transplantation (TI-NDMM)P3recruiting520GlaxoSmithKlineDec 2024
NCT07614360DREAMM-16Study of Alternative and Approved Dosing Regimens of Belantamab Mafodotin, Bortezomib, and Dexamethasone (BVd) in Participants With Relapsed/Refractory Multiple MyelomaP2not yet recruiting120GlaxoSmithKlineAug 2026
NCT05922501ISABELAIsatuximab, Bela Maf, Pom, and Dex in Relapsed/Refractory Multiple MyelomaP2recruiting50Massachusetts General HospitalMay 2024
NCT07227311RRMMA Study to Evaluate the Efficacy and Safety of Belantamab Mafodotin in Combination With Standard of Care in Participants With Relapsed-Refractory Multiple Myeloma (RRMM)P2recruiting200GlaxoSmithKlineApr 2026
NCT06232044Testing the Combination of Two Approved Drugs and One Experimental Drug in Patients With Relapsed or Refractory Multiple MyelomaP1/P2recruiting88Alliance for Clinical Trials in OncologyApr 2025
NCT05714839DREAMM-20A Study to Investigate the Safety and Efficacy of Belantamab for the Treatment of Multiple Myeloma When Used as Monotherapy and in Combination TreatmentsP1/P2recruiting152GlaxoSmithKlineJun 2023
NCT06956170DREAMM 8All Japanese Population: Belantamab Mafodotin Plus Pomalidomide and Dexamethasone (Pd) Versus Bortezomib Plus Pd in Relapsed/Refractory Multiple MyelomaP3active not recruiting21GlaxoSmithKlineFeb 2022
NCT04484623DREAMM 8Belantamab Mafodotin Plus Pomalidomide and Dexamethasone (Pd) Versus Bortezomib Plus Pd in Relapsed/Refractory Multiple MyelomaP3active not recruiting302GlaxoSmithKlineOct 2020
NCT05853965BELI(E)VECombination Treatment of Belantamab Mafodotin and Venetoclax in Treatment of Relapsed and Refractory t(11;14) Multiple MyelomaP1/P2recruiting45Universitätsklinikum Hamburg-EppendorfJun 2023
NCT04808037BelaRdBlmf, Lenalidomide and Dexamethasone in Transplant-ineligible Patients With Newly Diagnosed Multiple MyelomaP1/P2active not recruiting66Hellenic Society of HematologyFeb 2021
NCT05789303Study of Belantamab Mafodotin With Carfilzomib, Pomalidomide, and Dexamethasone in Relapsed Multiple MyelomaP2recruiting83University of ChicagoMay 2023
NCT05874193COSTAA Collaborative Community Effort Using Belantamab Mafodotin in Relapsed/Refractory MyelomaP2not yet recruiting33Cristiana Costa Chase, DOMay 2026
NCT06868654DREAMM 7China Subpopulation: Evaluation of Efficacy and Safety of Belantamab Mafodotin, Bortezomib and Dexamethasone Versus Daratumumab, Bortezomib and Dexamethasone in Participants With Relapsed/Refractory Multiple MyelomaP3active not recruiting72GlaxoSmithKlineJul 2021
NCT06868667DREAMM 7Japan Expansion Cohort: Evaluation of Efficacy and Safety of Belantamab Mafodotin, Bortezomib and Dexamethasone Versus Daratumumab, Bortezomib and Dexamethasone in Participants With Relapsed/Refractory Multiple MyelomaP3active not recruiting24GlaxoSmithKlineJul 2021
NCT04246047DREAMM 7Evaluation of Efficacy and Safety of Belantamab Mafodotin, Bortezomib and Dexamethasone Versus Daratumumab, Bortezomib and Dexamethasone in Participants With Relapsed/Refractory Multiple MyelomaP3active not recruiting494GlaxoSmithKlineMay 2020
NCT05060627Study of Belantamab Mafodotin in Combination With Kd for the Treatment of Relapsed Myeloma Patients, Refractory to LenalidomideP1/P2active not recruiting60PETHEMA FoundationDec 2021
NCT04643002Isatuximab in Combination With Novel Agents in RRMM - Master ProtocolP1/P2recruiting258SanofiJan 2021
NCT05091372Minimal Residual Disease Guided Maintenance Therapy With Belantamab Mafodotin and Lenalidomide After Autologous Hematopoietic Cell Transplantation in Patients With Newly Diagnosed Multiple MyelomaP2recruiting94M.D. Anderson Cancer CenterDec 2022
NCT05208307Belantamab Mafodotin, Pomalidomide and Dexamethasone for the Treatment of High-Risk MyelomaP2recruiting34Emory UniversityJul 2022
NCT04876248Belantamab Mafodotin and Lenalidomide for the Treatment of Multiple Myeloma in Patients With Minimal Residual Disease Positive After Stem Cell TransplantP2active not recruiting4Roswell Park Cancer InstituteAug 2024
NCT05145816Phase 1/2a Study of Belantamab Mafodotin in Relapsed or Refractory AL AmyloidosisP1/P2recruiting37University of Texas Southwestern Medical CenterFeb 2024
NCT07019545BONSAIA PHASE II TRIAL AIMING TO INVESTIGATE THE SAFETY AND CLINICAL ACTIVITY OF BELANTAMAB MAFODOTIN IN ADULT PATIENTS WITH PRIMARY IMMUNE THROMBOCYTOPENIA PREVIOUSLY TREATED WITH A THROMBOPOIETIN RECEPTOR AGONIST AND/OR RITUXIMAB AFTER CORTICOSTEROID FIRST-LINE THERAPYP2not yet recruiting14Hellenic Society of HematologyJun 2025
NCT02343042STOMPSelinexor and Backbone Treatments of Multiple Myeloma PatientsP1/P2active not recruiting300Karyopharm Therapeutics IncOct 2015
NCT07150104GSK2857916Sub-study of Belantamab Mafodotin (GSK2857916) as Monotherapy and in Combination With Nirogacestat, Pomalidomide, and Dexamethasone in Participants With RRMMP1/P2active not recruiting14GlaxoSmithKlineAug 2022
NCT07150091GSK2857916Sub-study of Belantamab Mafodotin (GSK2857916) in Combination With Nirogacestat, Lenalidomide, and Dexamethasone in Participants With RRMMP1/P2active not recruiting20GlaxoSmithKlineJul 2022
NCT07217184GSK2857916Sub-study of Belantamab Mafodotin (GSK2857916) in Combination With Isatuximab in Participants With RRMMP1/P2active not recruiting30GlaxoSmithKlineJul 2021
NCT07084896GSK2857916Sub-study of Belantamab Mafodotin (GSK2857916) in Combination With Nirogacestat in Participants With RRMMP1/P2active not recruiting106GlaxoSmithKlineJun 2020
NCT04162210DREAMM-3Study of Single Agent Belantamab Mafodotin Versus Pomalidomide Plus Low-dose Dexamethasone (Pom/Dex) in Participants With Relapsed/Refractory Multiple Myeloma (RRMM)P3active not recruiting325GlaxoSmithKlineApr 2020
NCT07217119GSK2857916Sub-study of Belantamab Mafodotin (GSK2857916) in Combination With Feladilimab (GSK3359609) in Participants With RRMMP1/P2active not recruiting25GlaxoSmithKlineNov 2019
NCT04126200DREAMM 5Platform Study of Belantamab Mafodotin as Monotherapy and in Combination With Anti-cancer Treatments in Participants With Relapsed/Refractory Multiple Myeloma (RRMM)P1/P2active not recruiting208GlaxoSmithKlineOct 2019
NCT05055063A Phase 1 With Extension Cohort, Single Arm, Single Center, Open Label Trial of Belantamab Mafodotin for the Treatment of High-Risk Smoldering Multiple MyelomaP1recruiting30M.D. Anderson Cancer CenterMay 2022
NCT05002816Novel Combination of Belantamab Mafodotin and Elotuzumab to Enhance Therapeutic Efficacy in Multiple MyelomaP1/P2active not recruiting24Yale UniversityFeb 2022
NCT04091126DREAMM 9Study of Belantamab Mafodotin Plus Standard of Care (SoC) in Newly Diagnosed Multiple MyelomaP1active not recruiting118GlaxoSmithKlineDec 2019
NCT05573802A Study to Investigate Safety and Clinical Activity of Belantamab Mafodotin in Combination With Lenalidomide, Dexamethasone and Nirogacestat in Patients With Transplant Ineligible Newly Diagnosed Multiple MyelomaP1/P2recruiting36Hellenic Society of HematologyJul 2023
NCT05581875A Study to Investigate the Safety and Clinical Activity of Belantamab Mafodotin in Combination With Daratumumab, Pomalidomide and Dexamethasone in Patients With Relapsed/ Refractory Multiple Myeloma Previously Treated With One Line Therapy Who Are Lenalidomide RefractoryP1/P2not yet recruiting48Hellenic Society of HematologyOct 2022
NCT05556798A Study of Belantamab Mafodotin in Combination With Nirogacestat and Pomalidomide in People With Multiple Myeloma That Has Not Responded to Treatment or Has Come Back After TreatmentP1active not recruiting9Memorial Sloan Kettering Cancer CenterOct 2022
NCT04680468Study of Belantamab Mafodotin as Pre- and Post-autologous Stem Cell Transplant and Maintenance for Multiple MyelomaP2active not recruiting41University of PennsylvaniaJun 2021
NCT04802356Belantamab Mafodotin in Newly Diagnosed Transplant Eligible Multiple Myeloma PatientsP2active not recruiting50PETHEMA FoundationApr 2021
NCT05280275A Study to Investigate the Safety and Clinical Activity of Belantamab Mafodotin in Combination With Daratumumab, Lenalidomide and Dexamethasone in Patients With Newly Diagnosed Multiple Myeloma Transplant IneligibleP1/P2unknown36Hellenic Society of HematologyApr 2022
NCT05064358DREAMM 14Study to Investigate Alternative Dosing Regimens of Belantamab Mafodotin in Participants With Relapsed or Refractory Multiple MyelomaP2completed177GlaxoSmithKlineMar 2022
NCT04398745DREAMM12A Study of Belantamab Mafodotin Monotherapy in Multiple Myeloma Participants With Normal and Varying Degree of Impaired Renal FunctionP1active not recruiting36GlaxoSmithKlineOct 2020
NCT05493618Pembrolizumab, Belantamab and Dexamethasone in Refractory Multiple Myeloma.P1/P2withdrawn0Hackensack Meridian HealthDec 2022
NCT05065047Belantamab Mafadotin Maintenance Therapy After Salvage Autologous Hematopoietic Cell Transplantation in Patients With Relapse Refractory Multiple MyelomaP1terminated6M.D. Anderson Cancer CenterJan 2023
NCT04398680DREAMM 13A Study of Belantamab Mafodotin in Multiple Myeloma Participants With Normal and Impaired Hepatic FunctionP1withdrawn0GlaxoSmithKlineApr 2021
NCT04617925EMN27A Study of Belantamab Mafodotin in Patients With Relapsed or Refractory AL AmyloidosisP2completed35Stichting European Myeloma NetworkFeb 2021
NCT06413511A Study to Investigate the Safety and Pharmacological Effect of a Single Intravenous Infusion of Belantamab in Male and Female Participants Aged 18 to 75 With Autoimmune DiseaseP1withdrawn0GlaxoSmithKlineJun 2024
NCT05833737Corneal Findings in Patients Treated With Belantamab Mafodotinterminated12Medical University of ViennaJun 2023
NCT03732703MyDRUGMyeloma-Developing Regimens Using Genomics (MyDRUG)P1/P2completed103Multiple Myeloma Research ConsortiumApr 2019
NCT04896658Belantamab Mafodotin, Cyclophosphamide, and Dexamethasone in Relapsed/Refractory Multiple MyelomaP1/P2terminated10University of Maryland, BaltimoreDec 2021
NCT04676360Belantamab Mafodotin In Plasmablastic Lymphoma & ALK+ Large B-Cell LymphomaP2terminated10Jacob Soumerai, MDJul 2021
NCT05461209MonumenTAL-5A Study of Comparing Talquetamab to Belantamab Mafodotin in Participants With Relapsed/Refractory Multiple MyelomaP3withdrawn0Janssen Research & Development, LLCOct 2022
NCT03525678A Study to Investigate the Efficacy and Safety of Two Doses of GSK2857916 in Participants With Multiple Myeloma Who Have Failed Prior Treatment With an Anti-CD38 AntibodyP2completed221GlaxoSmithKlineJun 2018
NCT03828292An Open-label, Dose Escalation Study in Japanese Participants With Relapsed/Refractory Multiple Myeloma Who Have Failed Prior Anti Myeloma TreatmentsP1completed15GlaxoSmithKlineMar 2019
NCT05393024Patient With MMRR Treated With Belantamab Mafotidine on Monotherapycompleted78Fondazione EMN Italy OnlusJul 2022
NCT04892264Belantamab Mafodotin, Lenalidomide, and Daratumumab for the Treatment of Relapsed, Refractory, or Previously Untreated Multiple MyelomaP1terminated5Mayo ClinicJun 2021
NCT03544281DREAMM 6To Evaluate Safety, Tolerability, and Clinical Activity of the Antibody-drug Conjugate, GSK2857916 Administered in Combination With Lenalidomide Plus Dexamethasone (Arm A), or in Combination With Bortezomib Plus Dexamethasone (Arm B) in Participants With Relapsed/Refractory Multiple Myeloma (RRMM)P1/P2completed153GlaxoSmithKlineSep 2018
NCT06655818GSK2857916Sub-study of Belantamab Mafodotin (GSK2857916) as Monotherapy and in Combination With Dostarlimab (GSK4057190) in Participants With RRMMP1/P2terminated4GlaxoSmithKlineMar 2021
NCT05117008EMBRACEMaintenance Belantamab Mafodotin (Blenrep®) After B-cell Maturation Antigen-Directed Chimeric Antigen Receptor T-cell Therapy in Patients With Relapsed and/or Refractory Multiple MyelomaP2terminated1Medical College of WisconsinJul 2022
NCT03848845DREAMM 4Study Evaluating Safety, Tolerability and Clinical Activity of GSK2857916 in Combination With Pembrolizumab in Subjects With Relapsed/Refractory Multiple Myeloma (RRMM)P1/P2completed41GlaxoSmithKlineMar 2019
NCT06160609GSK2857916Platform Sub-study of Belantamab Mafodotin (GSK2857916) in Combination With aOX40 (GSK3174998) in Participants With RRMMP1/P2terminated9GlaxoSmithKlineOct 2019
NCT05297240RRMMRetrospective Study of the Use of Belantamab Mafodotin (Blenrep®) in Patients With Relapsed and/or Refractory Multiple Myeloma (RRMM) in Spain.unknown170PETHEMA FoundationMar 2022
NCT04549363Characterization of Corneal Epithelial Changes in Participants Treated With Belantamab MafodotinP3terminated16GlaxoSmithKlineDec 2020
NCT04177823RRMMA Study of Belantamab Mafodotin to Investigate Safety, Tolerability, Pharmacokinetics, Immunogenicity and Clinical Activity in Participants With Relapsed/Refractory Multiple Myeloma (RRMM)P1completed6GlaxoSmithKlineDec 2019
NCT03763370Managed Access Program for Combination Treatment With Belantamab Mafodotin in Multiple Myelomaavailable0GlaxoSmithKline

Belantamab mafodotin clinical trials: frequently asked questions

How many Belantamab mafodotin clinical trials are there?
69 Belantamab mafodotin clinical trials are catalogued on Hipa.ai, sourced from the AACT mirror of ClinicalTrials.gov. 14 are actively recruiting participants. 9 are marked completed.
Are Belantamab mafodotin clinical trials recruiting in 2026?
Yes — 14 Belantamab mafodotin trials are actively recruiting in 2026, with 93 U.S. sites across 29 states. See the recruiting trials and the per-state site list further down this page.
What conditions is Belantamab mafodotin being studied for?
Belantamab mafodotin is being studied for Multiple Myeloma, Refractory Multiple Myeloma, Relapsed/Refractory Multiple Myeloma, Plasma Cell Myeloma, Corneal Disease and 31 more. The trials are grouped by indication on this page.
What phase is Belantamab mafodotin in?
Belantamab mafodotin clinical trials span 10 Phase 3, 18 Phase 2, 11 Phase 1. The phase × status matrix at the top of this page breaks down counts by phase and recruitment status.
Who sponsors Belantamab mafodotin clinical trials?
The lead sponsor across the most Belantamab mafodotin trials is GlaxoSmithKline, with 28 additional lead sponsors listed in the data. Each trial row links to the full study detail page including sponsor information.

Sources and methodology

Trial inventory derived from the AACT mirror of ClinicalTrials.gov. Trials are filtered to those naming Belantamab mafodotinas an intervention. Phase, status, enrollment, sponsor, and dates are taken from the source `studies` table; primary indication is the first listed condition. Acronyms are extracted from each trial's brief title where present. PubMed links are populated for trials whose published primary outcomes have been indexed in our evidence cache.

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