How many Afimkibart clinical trials are there?

10 Afimkibart clinical trials are catalogued on Hipa.ai, sourced from the AACT mirror of ClinicalTrials.gov. 7 are actively recruiting participants.

Are Afimkibart clinical trials recruiting in 2026?

Yes — 7 Afimkibart trials are actively recruiting in 2026, with 226 U.S. sites across 32 states. See the recruiting trials and the per-state site list further down this page.

What conditions is Afimkibart being studied for?

Afimkibart is being studied for Moderately to Severely Active Crohns Disease, Moderately to Severely Active Ulcerative Colitis, Atopic Dermatitis, Crohns Disease, Rheumatoid Arthritis. The trials are grouped by indication on this page.

What phase is Afimkibart in?

Afimkibart clinical trials span 6 Phase 3, 4 Phase 2. The phase × status matrix at the top of this page breaks down counts by phase and recruitment status.

Who sponsors Afimkibart clinical trials?

The lead sponsor across the most Afimkibart trials is Hoffmann-La Roche. Each trial row links to the full study detail page including sponsor information.

Afimkibart Clinical Trials (2026): 10 Studies for Moderately to Severely Active Crohns Disease & Moderately to Severely Active Ulcerative Colitis

Creator: Hipa.ai Research
Published: 2026-05-01T18:31:24.373Z

Hipa.ai Research · Source: ClinicalTrials.gov / AACT

Synced daily from ClinicalTrials.gov via AACT. Last sync: June 18, 2026.

10 Afimkibart clinical trials are catalogued on Hipa.ai from the AACT mirror of ClinicalTrials.gov, spanning 5 indications (including Moderately to Severely Active Crohns Disease & Moderately to Severely Active Ulcerative Colitis) and 2,436 total planned enrollment. 6 Phase 3 Afimkibart trials and 4 Phase 2 are listed. 7 Afimkibart clinical trials are actively recruiting at 226 U.S. sites across 32 states. Most recent activity: NCT06819878 (Dec 2033).

Where to Participate: All Afimkibart Trial Sites in the U.S. (226 sites across 32 states)

Every actively recruiting Afimkibarttrial site, sorted by state then city. Each row links to the trial detail page (eligibility, contacts, full study record). Sites no longer enrolling at the location level are excluded. ClinicalTrials.gov / AACT does not provide street-level addresses; the map link uses the facility's geocoded coordinates where available.

State	Facility	City	Trial	Map
AL	Digestive Health Specialists of the Southeast (Gastroenterology Associates of Dothan) - Dothan	Dothan36305	NCT06588855	Map
AL	Digestive Health Specialists of the Southeast (Gastroenterology Associates of Dothan) - Dothan	Dothan36305	NCT06819878	Map
AZ	Sun City Clinical Research	Glendale85304	NCT06819891	Map
AZ	SunValley Arthritis Center Ltd.	Peoria85381	NCT07137598	Map
AZ	Mayo Clinic Hospital	Phoenix85054	NCT06819878	Map
AZ	Mayo Clinic Hospital	Scottsdale85259	NCT06588855	Map
AZ	Arizona Digestive Health, P.C (ADH)	Sun City85351	NCT06588855	Map
AZ	Arizona Digestive Health, P.C (ADH)	Sun City85351	NCT06819878	Map
AZ	University of Arizona-CATS Research Center	Tucson85724	NCT06819878	Map
CA	Om Research LLC	Apple Valley92307	NCT06588855	Map
CA	Valley View Internal Medicine	Garden Grove92845	NCT06588855	Map
CA	Valley View Internal Medicine	Garden Grove92845-2006	NCT06819878	Map
CA	310 Clinical Research	Inglewood90301	NCT06819878	Map
CA	UCSD Medical Center	La Jolla92037-0897	NCT06819878	Map
CA	Gastro Care Associates	Lancaster93534	NCT06588855	Map
CA	Gastro Care Associates	Lancaster93534	NCT06819878	Map
CA	Om Research LLC	Lancaster93534	NCT06819878	Map
CA	Om Research LLC	Lancaster93534	NCT06819891	Map
CA	United Gastroenterologists	Los Alamitos90720	NCT06819878	Map
CA	Cedars Sinai Medical Center	Los Angeles90048	NCT07137598	Map
CA	University of Southern California	Los Angeles90033-1057	NCT06588855	Map
CA	Hoag Memorial Hospital Presbyterian;Hoag Center for Research and Education	Newport Beach92663	NCT06588855	Map
CA	Hoag Memorial Hospital Presbyterian;Hoag Center for Research and Education	Newport Beach92663	NCT06819891	Map
CA	Stanford Medicine Outpatient Center	Redwood City94063	NCT06588855	Map
CA	Stanford Medicine Outpatient Center	Redwood City94063	NCT06819891	Map
CA	Acclaim Clinical Research, Inc.	San Diego92120	NCT06819878	Map
CA	Clinical Applications Laboratories, Inc.	San Diego92103	NCT06819891	Map
CA	Kaiser Permanente	San Francisco94115	NCT06819878	Map
CA	UCSF/Medical Center at Mount Zion	San Francisco94115	NCT06819878	Map
CA	Amicis Research Center	Santa Clarita91355	NCT06819891	Map
CA	Inland Rheumatology Clinical Trials Incorporated	Upland91786	NCT07137598	Map
CO	Peak Gastroenterology Associates	Colorado Springs80907	NCT06588855	Map
CO	Peak Gastroenterology Associates	Colorado Springs80907	NCT06819891	Map
CO	Rocky Mountain Gastroenterology	Littleton80120	NCT06819878	Map
CO	Peak Gastroenterology Surgery Center	Lone Tree80124	NCT06819878	Map
FL	Access Research Institute	Brooksville34613	NCT06819878	Map
FL	Gastro Florida	Clearwater33756	NCT06819878	Map
FL	HealthMed Clinical Center Inc.	Coral Gables33134	NCT06819878	Map
FL	Hi Tech and Global Research, LLC	Coral Gables33134	NCT06588855	Map
FL	Hi Tech and Global Research, LLC	Coral Gables33134	NCT06819878	Map
FL	J&A Clinical Research	Doral33126	NCT06819891	Map
FL	NeoClinical Research	Hialeah33016	NCT06819878	Map
FL	The Sister Life Research	Hialeah33013	NCT06588855	Map
FL	The Sister Life Research	Hialeah33013	NCT06819878	Map
FL	Clinical Research of Osceola, LLC	Kissimmee34741	NCT06819878	Map
FL	Auzmer Research	Lakeland33813	NCT06819891	Map
FL	Florida Research Institute - Lakewood	Lakewood Rch34211	NCT06819878	Map
FL	Galenus Group Inc	Lehigh Acres33936	NCT06819891	Map
FL	Allied Biomedical Research Institute	Miami33155	NCT06588855	Map
FL	Allied Biomedical Research Institute, Inc	Miami33155	NCT06819891	Map
FL	Homestead Associates in Research, Inc.	Miami33033	NCT06819891	Map
FL	LCC Medical Research Institute, LLC	Miami33126	NCT06588855	Map
FL	LCC Medical Research Institute, LLC	Miami33126	NCT06819878	Map
FL	Rejuvaline Medical Research	Miami33155	NCT06819891	Map
FL	Miami Beach Clinical Research Center	Miami Beach33141	NCT06819891	Map
FL	Eminat Research Group	Miramar33027	NCT06819891	Map
FL	Digestive and Liver Center of Florida	Orlando32825	NCT06588855	Map
FL	Digestive and Liver Center of Florida	Orlando32825	NCT06819891	Map
FL	Integrity Trials LLC	Orlando32807	NCT06588855	Map
FL	Orlando Regional Healthcare	Orlando32806	NCT06819878	Map
FL	Advanced Medical Research Center	Port Orange32127	NCT06588855	Map
FL	Advanced Medical Research Center	Port Orange32127	NCT06819891	Map
FL	West Broward Rheumatology Associates, Inc.	Tamarac33321	NCT07137598	Map
FL	Guardian Angel Research Center, LLC	Tampa33614	NCT06588855	Map
FL	Guardian Angel Research Center, LLC	Tampa33614	NCT06819878	Map
FL	Nodal Medical Center Research - NMC	Tampa33607	NCT06819878	Map
FL	Santos Research Center, CORP	Tampa33615	NCT06588855	Map
FL	Santos Research Center, CORP	Tampa33615	NCT06819891	Map
FL	University of South Florida School of Medicine Morsani Center for Advanced Health Care	Tampa33612	NCT06588855	Map
FL	University of South Florida School of Medicine Morsani Center for Advanced Health Care	Tampa33612	NCT06819878	Map
FL	Theia Clinical Research Centers, LLC	Temple Terrace33617	NCT06819878	Map
FL	Cleveland Clinic Florida	Weston33331	NCT06588855	Map
FL	Cleveland Clinic Florida	Weston33331	NCT06819878	Map
FL	Cleveland Clinic Florida	Weston33331	NCT06819891	Map
FL	Florida Medical Clinic - Orlando Health	Zephyrhills33542	NCT06819878	Map
GA	Hamilton Research, LLC	Alpharetta30022	NCT07223697	Map
GA	Atlanta Gastroenterology Associates	Atlanta30342	NCT06588855	Map
GA	Atlanta Gastroenterology Associates	Atlanta30342	NCT06819878	Map
GA	Children's Healthcare of Atlanta	Atlanta30342	NCT07158242	Map
GA	Digestive Healthcare of Georgia	Atlanta30327	NCT06819878	Map
GA	Randomize Now, LLC	Atlanta30308	NCT06588855	Map
GA	Gastroenterology Associates of Central Georgia	Macon31201	NCT06588855	Map
GA	Gastroenterology Associates of Central Georgia	Macon31201	NCT06819878	Map
ID	Grand Teton Research Group, PLLC	Idaho Falls83404	NCT06588855	Map
ID	Grand Teton Research Group, PLLC	Idaho Falls83404	NCT06819878	Map
IL	Northwestern Memorial Hospital	Chicago60611	NCT06819878	Map
IL	The University of Chicago	Chicago60637	NCT06819891	Map
IL	Illinois Gastroenterology Group-Glenview powered by GI Alliance	Glenview60026	NCT06588855	Map
IL	Illinois Gastroenterology Group-Glenview powered by GI Alliance	Glenview60026	NCT06819878	Map
IL	GI Alliance - Gurnee	Gurnee60031	NCT06588855	Map
IL	GI Alliance - Gurnee	Gurnee60031	NCT06819878	Map
IL	Willow Rheumatology and Wellness PLLC	Willowbrook60527	NCT07137598	Map
IN	Indiana University Health University Hospital	Indianapolis46202	NCT06819878	Map
IN	Gastro Health Partners, LLC	New Albany47150	NCT06588855	Map
IN	Gastroenterology Health Partners, PLLC	New Albany47150	NCT06819878	Map
KS	Kansas Gastroenterology, LLC under Clinical Trials Network	Wichita67226	NCT06588855	Map
KS	Kansas Gastroenterology, LLC under Clinical Trials Network	Wichita67226	NCT06819878	Map
KY	Tri-State Gastroenterology Associates	Crestview Hills41017-3409	NCT06819878	Map
KY	Gastroenterology Health Partners, PLLC	Louisville40218	NCT06819878	Map
KY	One GI: GHP - Gastroenterology Health Partners Louisville	Louisville40218	NCT06588855	Map
KY	Robley Rex VA Medical Center	Louisville40206	NCT06819891	Map
LA	Baton Rouge General Medical Center	Baton Rouge70809	NCT06819891	Map
LA	Accurate Clinical Research Inc.	Lake Charles70605	NCT07137598	Map
LA	Louisiana Research Center - GastroIntestinal Associates	Shreveport71105	NCT06588855	Map
LA	Louisiana Research Center - GastroIntestinal Associates	Shreveport71105	NCT06819891	Map
MD	Mercy Medical Center	Baltimore21202	NCT06819891	Map
MD	Chevy Chase Clinical Research	Chevy Chase20815	NCT06819891	Map
MA	Boston University	Boston02118	NCT06819878	Map
MA	Brigham and Women's Hospital	Boston02115	NCT06819878	Map
MA	University of Massachusetts Memorial Medical Center	North Worcester01655	NCT06819891	Map
MI	Michigan Center of Medical Research	Farmington Hills48334	NCT06819878	Map
MI	Revival Research Institute, LLC	Troy48084	NCT07223697	Map
MI	Gastroenterology Associates of Western Michigan, P.L.C.	Wyoming49519	NCT06819891	Map
MS	Allied Gastrointestinal Associates, PA	Flowood39232	NCT06588855	Map
MS	Gastrointestinal Associates Research	Flowood39232	NCT06819891	Map
MS	Gastroenterology Associates and Endoscopy Center of North Mississippi	Oxford38655	NCT06819878	Map
MS	Delta Gastroenterology & Endoscopy Center	Southaven38671	NCT06588855	Map
MS	Delta Gastroenterology & Endoscopy Center	Southaven38671	NCT06819878	Map
NV	Las Vegas Clinical Trials, LLC	North Las Vegas89030	NCT06819878	Map
NH	Dartmouth-Hitchcock Medical Center-Norris Cotton Cancer Center	Lebanon03756	NCT06588855	Map
NJ	Virtua Crohns and Colitis Center	Moorestown08057	NCT06819891	Map
NJ	Robert Wood Johnson University Hospital	New Brunswick08901	NCT06819891	Map
NY	Ellipsis Research Group	Brooklyn11215	NCT06588855	Map
NY	Ellipsis Research Group	Brooklyn11215	NCT06819891	Map
NY	Intercity Gastroenterology	Fresh Meadows11366	NCT06819891	Map
NY	Lenox Hill Hospital	New York10075	NCT06819878	Map
NY	Mount Sinai Hospital - IBD Clinical Center	New York10029	NCT06819878	Map
NY	NYU Inflammatory Bowel Disease Center	New York10016	NCT06588855	Map
NY	NYU Langone Health	New York10016	NCT07158242	Map
NY	Weill Cornell Medical College	New York10021	NCT06588855	Map
NY	DiGiovanna Inst for Med Ed&Res	North Massapequa11758	NCT06588855	Map
NY	DiGiovanna Inst for Med Ed&Res	North Massapequa11758	NCT06819878	Map
NY	Queens Village Medical Care	Queens Village11428	NCT06588855	Map
NY	Queens Village Medical Care	Queens Village11428	NCT06819878	Map
NY	Mainstreet - Richmond Hill Clinic	Richmond Hill11418	NCT06819878	Map
NY	Gastroenterology Group Of Rochester, LLP	Rochester14618	NCT06588855	Map
NY	Gastroenterology Group Of Rochester, LLP	Rochester14618	NCT06819878	Map
NY	University of Rochester Medical Center	Rochester14642	NCT06819878	Map
NY	James J Peters Veterans Administration Medical Center - NAVREF	The Bronx10468	NCT06588855	Map
NY	James J Peters Veterans Affairs Medical Center	The Bronx10468	NCT06819891	Map
NY	Digestive Disease Medicine of Central New York	Utica13502	NCT06819891	Map
NC	Atrium Health, Carolinas Healthcare System	Charlotte28204	NCT06819878	Map
NC	Charlotte Gastroenterology and Hepatology, P.L.L.C	Charlotte28207	NCT06588855	Map
NC	Charlotte Gastroenterology and Hepatology, P.L.L.C	Charlotte28207	NCT06819891	Map
NC	Omega Research North Carolina, LLC	Fuquay-Varina27526	NCT06588855	Map
NC	Omega Research North Carolina, LLC	Fuquay-Varina27526	NCT06819878	Map
NC	Peters Medical Research (PMR), LLC	High Point27260	NCT06588855	Map
NC	Peters Medical Research (PMR), LLC	High Point27260	NCT06819891	Map
NC	Monroe Biomedical Research	Monroe28112	NCT06819878	Map
OH	Clinical Inquest Center	Beavercreek45431	NCT06819891	Map
OH	Dayton Gastroenterology, Inc.	Beavercreek45440	NCT06588855	Map
OH	Dayton Gastroenterology, Inc.	Beavercreek45440	NCT06819878	Map
OH	Digestive Disease Consultants	Brunswick44212	NCT06819878	Map
OH	University of Cincinnati Hospital	Cincinnati45267	NCT06588855	Map
OH	University of Cincinnati Hospital	Cincinnati45267	NCT06819878	Map
OH	Cleveland Clinic Foundation	Cleveland44195	NCT06588855	Map
OH	Cleveland Clinic Foundation	Cleveland44195	NCT06819878	Map
OH	Cleveland Clinic Foundation	Cleveland44195	NCT06819891	Map
OH	Ohio Gastroenterology Group	Columbus43202	NCT06588855	Map
OH	Ohio Gastroenterology Group	Columbus43202	NCT06819878	Map
OH	Ohio State University	Columbus43210	NCT06588855	Map
OH	Ohio State University Wexner Medical Center	Columbus43203	NCT07137598	Map
OH	The Ohio State University Wexner Medical Center	Columbus43210	NCT06819878	Map
OH	Gastro Health- Liberty	Liberty Township45044	NCT06819878	Map
OH	Gastro Intestinal Research Institute of Northern Ohio	Westlake44145	NCT06588855	Map
OH	Gastro Intestinal Research Institute of Northern Ohio	Westlake44145	NCT06819878	Map
OK	Central Sooner Research	Norman73071	NCT06819878	Map
PA	Best Skin Research LLC	Camp Hill17011	NCT07223697	Map
PA	Altoona Center For Clinical Research	Duncansville16635	NCT07137598	Map
PA	Penn State Milton S. Hershey Medical Center	Hershey17033	NCT06819878	Map
PA	University of Pennsylvania	Philadelphia19104	NCT06819891	Map
PA	Frontier Clinical Re search, LLC	Uniontown15401	NCT06588855	Map
PA	Frontier Clinical Re search, LLC	Uniontown15401-9069	NCT06819878	Map
RI	University Gastroenterology	Providence02904	NCT06588855	Map
RI	University Gastroenterology	Providence02904	NCT06819878	Map
SC	Medical University of South Carolina	Charleston29425	NCT06819878	Map
SC	Gastroenterology Associates	Greenville29607	NCT06588855	Map
SC	Gastroenterology Associates	Greenville29607	NCT06819878	Map
TN	Gastro One	Cordova38018	NCT06588855	Map
TN	Gastro One	Germantown38138	NCT06819878	Map
TN	Quality Medical Research	Nashville37211	NCT06819878	Map
TN	Vanderbilt University Medical Center	Nashville37212-1375	NCT06819891	Map
TX	Texas Clinical Research Institute, LLC	Arlington76012	NCT06819878	Map
TX	University of Texas Southwestern Medical Center - Multidisciplinary Spine Clinic - James W. Aston Ambulatory Care Center	Dallas75390-8565	NCT06819891	Map
TX	Proactive El Paso,LLC	El Paso79902	NCT06819878	Map
TX	GI Alliance - Fort Worth	Fort Worth76104	NCT06819891	Map
TX	Uni of Texas Medical Branch	Galveston77555	NCT06588855	Map
TX	GI Alliance	Garland75044	NCT06588855	Map
TX	GI Alliance	Garland75044	NCT06819891	Map
TX	Amel Med LLC	Georgetown78628	NCT06588855	Map
TX	Amel Med LLC	Georgetown78628	NCT06819878	Map
TX	Cano Medical Center	Harlingen78550	NCT06588855	Map
TX	Cano Medical Center	Harlingen78550	NCT06819878	Map
TX	Texas Digestive Specialists	Harlingen78550	NCT06588855	Map
TX	Accurate Clinical Management	Houston77089	NCT07137598	Map
TX	Integrity Advanced Therapeutics PLLC	Houston77090	NCT06819891	Map
TX	GI Alliance - Bay Area Gastroenterology	Lubbock79410	NCT06588855	Map
TX	Texas Digestive Disease Consultants-Lubbock powered by GI Alliance	Lubbock79410	NCT06819891	Map
TX	TDDC dba GI Alliance Research	Mansfield76063	NCT06588855	Map
TX	TDDC dba GI Alliance Research	Mansfield76063	NCT06819878	Map
TX	SMS Clinical Research, LLC	Mesquite75149	NCT06819878	Map
TX	Carta - Clinical Associates In Research Therapeutics Of America;LLC	San Antonio78212	NCT06819891	Map
TX	Gastroenterology Research of America, LLC	San Antonio78229	NCT06819878	Map
TX	Southern Star Research Institute, LLC.	San Antonio78229	NCT06588855	Map
TX	GI Alliance - Southlake	Southlake76092	NCT06819878	Map
TX	Baylor Scott and White Medical Center	Temple76508	NCT06588855	Map
TX	Baylor Scott and White Medical Center	Temple76508	NCT06819878	Map
TX	DM Clinical Research	Tomball77375	NCT07137598	Map
TX	Tyler Research Institute, LLC	Tyler75701	NCT06588855	Map
TX	Tyler Research Institute, LLC	Tyler75701	NCT06819878	Map
TX	University of Texas Health Center at Tyler	Tyler75708	NCT06588855	Map
TX	University of Texas Health Center at Tyler	Tyler75708	NCT06819891	Map
TX	TDDC GI Alliance research Webster	Webster77598	NCT06588855	Map
TX	TDDC GI Alliance research Webster	Webster77598	NCT06819891	Map
VA	Gastroenterology Associates of Tidewater	Chesapeake23320	NCT06588855	Map
VA	Tidewater Clinical Research	Chesapeake23320	NCT07137598	Map
VA	Tidewater Gastroenterology Pllc T/A Gastro. Assoc. of Tidewater	Chesapeake23320	NCT06819878	Map
VA	Emeritas Research Group	Lansdowne Town Center20176	NCT06588855	Map
VA	Emeritas Research Group	Lansdowne Town Center20176	NCT06819878	Map
VA	Blue Ridge Medical Research - Gastroenterology Associates of Central Virginia	Lynchburg24502	NCT06819878	Map
VA	Gastroenterology Consultants and Endoscopy Center of Southwest Virginia	Roanoke24014	NCT06819878	Map
VA	Gastroenterology Consultants of SWVA	Roanoke24018	NCT06588855	Map
VA	Tidewater Physicians Multispecialty Group (TPMG) - Clinical Research Division - Williamsburg	Williamsburg23188	NCT06819878	Map
WA	The Vancouver Clinic	Vancouver98664	NCT06819878	Map
WV	University Physicians and Surgeons Inc, dba Marshall Health	Huntington25701	NCT06819891	Map
WI	Rheumatic Disease Center	Glendale53217	NCT07137598	Map

Afimkibart clinical trials at a glance: phase × recruitment status

Phase	recruiting	active not recruiting	Total
P2	2	2	4
P3	5	1	6

Recruiting Afimkibart clinical trials (7)

Studies currently enrolling participants. Click any NCT ID to view the trial detail page (eligibility, sites, contacts).

NCT ID	Title	Phase	Indication	Enrollment	Started
NCT06819878	SIBERITE-1A Study to Assess the Efficacy and Safety of Induction and Maintenance Therapy With Afimkibart (RO7790121) in Participants With Moderately to Severely Active Crohn's Disease	P3	Moderately to Severely Active Crohns Disease	600	Mar 2025
NCT06819891	SIBERITE-2A Study to Assess the Efficacy and Safety of Induction Therapy With Afimkibart (RO7790121) in Participants With Moderately to Severely Active Crohn's Disease	P3	Moderately to Severely Active Crohns Disease	425	May 2025
NCT07223697	Velarite-LTEA Long Term Extension Study to Evaluate the Safety and Efficacy of Afimkibart (RO7790121) in Participants With Atopic Dermatitis	P2	Atopic Dermatitis	120	Jan 2026
NCT07298421	SIBERITE-PEDSA Study to Assess the Pharmacokinetics, Effectiveness and Safety of Afimkibart for Induction and Maintenance Therapy in Children With Moderately to Severely Active Crohn's Disease	P3	Moderately to Severely Active Crohns Disease	100	Jun 2026
NCT07158242	AMETRINE-PEDSA Study to Evaluate the Pharmacokinetics, Safety and Efficacy of Afimkibart (RO7790121) in Children With Moderately to Severely Active Ulcerative Colitis	P3	Moderately to Severely Active Ulcerative Colitis	100	Apr 2026
NCT06588855	Ametrine-2A Study to Assess the Efficacy and Safety of Induction Therapy With Afimkibart (Also Known as RO7790121) in Participants With Moderately to Severely Active Ulcerative Colitis	P3	Moderately to Severely Active Ulcerative Colitis	350	Dec 2024
NCT07137598	TNFA Study to Assess the Efficacy and Safety of RO7790121 in Participants With Moderate to Severe Rheumatoid Arthritis Who Have Not Responded to or Who Cannot Tolerate Tumor Necrosis Factor (TNF) and/or Janus Kinase (JAK Inhibitors)	P2	Rheumatoid Arthritis	160	Dec 2025

Afimkibart clinical trials by indication

Moderately to Severely Active Crohns Disease (3)

NCT	Acronym	Phase	Status	Title
NCT06819878	SIBERITE-1	P3	recruiting	A Study to Assess the Efficacy and Safety of Induction and Maintenance Therapy With Afimkibart (RO7790121) in Participants With Moderately to Severely Active Crohn's Disease
NCT06819891	SIBERITE-2	P3	recruiting	A Study to Assess the Efficacy and Safety of Induction Therapy With Afimkibart (RO7790121) in Participants With Moderately to Severely Active Crohn's Disease
NCT07298421	SIBERITE-PEDS	P3	recruiting	A Study to Assess the Pharmacokinetics, Effectiveness and Safety of Afimkibart for Induction and Maintenance Therapy in Children With Moderately to Severely Active Crohn's Disease

Moderately to Severely Active Ulcerative Colitis (3)

NCT	Acronym	Phase	Status	Title
NCT07158242	AMETRINE-PEDS	P3	recruiting	A Study to Evaluate the Pharmacokinetics, Safety and Efficacy of Afimkibart (RO7790121) in Children With Moderately to Severely Active Ulcerative Colitis
NCT06588855	Ametrine-2	P3	recruiting	A Study to Assess the Efficacy and Safety of Induction Therapy With Afimkibart (Also Known as RO7790121) in Participants With Moderately to Severely Active Ulcerative Colitis
NCT06589986	Ametrine-1	P3	active not recruiting	A Study to Assess the Efficacy and Safety of Afimkibart (Also Known as RO7790121) for Induction and Maintenance Therapy in Participants With Moderately to Severely Active Ulcerative Colitis

Atopic Dermatitis (2)

NCT	Acronym	Phase	Status	Title
NCT07223697	Velarite-LTE	P2	recruiting	A Long Term Extension Study to Evaluate the Safety and Efficacy of Afimkibart (RO7790121) in Participants With Atopic Dermatitis
NCT06863961	RO7790121	P2	active not recruiting	A Study to Assess the Efficacy and Safety of Afimkibart (RO7790121) in Participants With Moderate to Severe Atopic Dermatitis

Rheumatoid Arthritis (1)

NCT	Acronym	Phase	Status	Title
NCT07137598	TNF	P2	recruiting	A Study to Assess the Efficacy and Safety of RO7790121 in Participants With Moderate to Severe Rheumatoid Arthritis Who Have Not Responded to or Who Cannot Tolerate Tumor Necrosis Factor (TNF) and/or Janus Kinase (JAK Inhibitors)

Crohns Disease (1)

NCT	Acronym	Phase	Status	Title
NCT05910528	TAHOE	P2	active not recruiting	Afimkibart (RO7790121) for the Treatment of Moderate to Severe Active Crohn's Disease

Afimkibart pivotal trial highlights (Phase 2/3/4)

Phase-2/3/4 studies with named acronyms — the registration-grade trials most cited in label discussions and Wikipedia.

Acronym	NCT	Phase	Status	Indication	Enrollment	PubMed
SIBERITE-1	NCT06819878	P3	recruiting	Moderately to Severely Active Crohns Disease	600	—
SIBERITE-2	NCT06819891	P3	recruiting	Moderately to Severely Active Crohns Disease	425	—
SIBERITE-PEDS	NCT07298421	P3	recruiting	Moderately to Severely Active Crohns Disease	100	—
AMETRINE-PEDS	NCT07158242	P3	recruiting	Moderately to Severely Active Ulcerative Colitis	100	—
Ametrine-2	NCT06588855	P3	recruiting	Moderately to Severely Active Ulcerative Colitis	350	—
Ametrine-1	NCT06589986	P3	active not recruiting	Moderately to Severely Active Ulcerative Colitis	400	—
Velarite-LTE	NCT07223697	P2	recruiting	Atopic Dermatitis	120	—
TAHOE	NCT05910528	P2	active not recruiting	Crohns Disease	21	—
TNF	NCT07137598	P2	recruiting	Rheumatoid Arthritis	160	—
RO7790121	NCT06863961	P2	active not recruiting	Atopic Dermatitis	160	—

All Afimkibart trials (10)

Sorted by most recent activity (completion → start → posted date). Each row links to the trial detail page on Hipa.ai.

NCT ID	Acronym	Title	Phase	Status	Enrollment	Sponsor	Started
NCT06819878	SIBERITE-1	A Study to Assess the Efficacy and Safety of Induction and Maintenance Therapy With Afimkibart (RO7790121) in Participants With Moderately to Severely Active Crohn's Disease	P3	recruiting	600	Hoffmann-La Roche	Mar 2025
NCT06819891	SIBERITE-2	A Study to Assess the Efficacy and Safety of Induction Therapy With Afimkibart (RO7790121) in Participants With Moderately to Severely Active Crohn's Disease	P3	recruiting	425	Hoffmann-La Roche	May 2025
NCT07223697	Velarite-LTE	A Long Term Extension Study to Evaluate the Safety and Efficacy of Afimkibart (RO7790121) in Participants With Atopic Dermatitis	P2	recruiting	120	Hoffmann-La Roche	Jan 2026
NCT07298421	SIBERITE-PEDS	A Study to Assess the Pharmacokinetics, Effectiveness and Safety of Afimkibart for Induction and Maintenance Therapy in Children With Moderately to Severely Active Crohn's Disease	P3	recruiting	100	Hoffmann-La Roche	Jun 2026
NCT07158242	AMETRINE-PEDS	A Study to Evaluate the Pharmacokinetics, Safety and Efficacy of Afimkibart (RO7790121) in Children With Moderately to Severely Active Ulcerative Colitis	P3	recruiting	100	Hoffmann-La Roche	Apr 2026
NCT06588855	Ametrine-2	A Study to Assess the Efficacy and Safety of Induction Therapy With Afimkibart (Also Known as RO7790121) in Participants With Moderately to Severely Active Ulcerative Colitis	P3	recruiting	350	Hoffmann-La Roche	Dec 2024
NCT06589986	Ametrine-1	A Study to Assess the Efficacy and Safety of Afimkibart (Also Known as RO7790121) for Induction and Maintenance Therapy in Participants With Moderately to Severely Active Ulcerative Colitis	P3	active not recruiting	400	Hoffmann-La Roche	Sep 2024
NCT05910528	TAHOE	Afimkibart (RO7790121) for the Treatment of Moderate to Severe Active Crohn's Disease	P2	active not recruiting	21	Hoffmann-La Roche	Jul 2023
NCT07137598	TNF	A Study to Assess the Efficacy and Safety of RO7790121 in Participants With Moderate to Severe Rheumatoid Arthritis Who Have Not Responded to or Who Cannot Tolerate Tumor Necrosis Factor (TNF) and/or Janus Kinase (JAK Inhibitors)	P2	recruiting	160	Hoffmann-La Roche	Dec 2025
NCT06863961	RO7790121	A Study to Assess the Efficacy and Safety of Afimkibart (RO7790121) in Participants With Moderate to Severe Atopic Dermatitis	P2	active not recruiting	160	Hoffmann-La Roche	Apr 2025

Afimkibart clinical trials: frequently asked questions

How many Afimkibart clinical trials are there?: 10 Afimkibart clinical trials are catalogued on Hipa.ai, sourced from the AACT mirror of ClinicalTrials.gov. 7 are actively recruiting participants.
Are Afimkibart clinical trials recruiting in 2026?: Yes — 7 Afimkibart trials are actively recruiting in 2026, with 226 U.S. sites across 32 states. See the recruiting trials and the per-state site list further down this page.
What conditions is Afimkibart being studied for?: Afimkibart is being studied for Moderately to Severely Active Crohns Disease, Moderately to Severely Active Ulcerative Colitis, Atopic Dermatitis, Crohns Disease, Rheumatoid Arthritis. The trials are grouped by indication on this page.
What phase is Afimkibart in?: Afimkibart clinical trials span 6 Phase 3, 4 Phase 2. The phase × status matrix at the top of this page breaks down counts by phase and recruitment status.
Who sponsors Afimkibart clinical trials?: The lead sponsor across the most Afimkibart trials is Hoffmann-La Roche. Each trial row links to the full study detail page including sponsor information.

Sources and methodology

Trial inventory derived from the AACT mirror of ClinicalTrials.gov. Trials are filtered to those naming Afimkibartas an intervention. Phase, status, enrollment, sponsor, and dates are taken from the source `studies` table; primary indication is the first listed condition. Acronyms are extracted from each trial's brief title where present. PubMed links are populated for trials whose published primary outcomes have been indexed in our evidence cache.

Last refreshed June 18, 2026.

Related pages on Hipa.ai:

Afimkibart overview