Acoramidis Clinical Trials (2026): 10 Studies for Amyloidosis & Cardiomyopathies

Hipa.ai Research · Source: ClinicalTrials.gov / AACT

Synced daily from ClinicalTrials.gov via AACT. Last sync: .

10 Acoramidis clinical trials are catalogued on Hipa.ai from the AACT mirror of ClinicalTrials.gov, spanning 8 indications (including Amyloidosis & Cardiomyopathies) and 4,140 total planned enrollment. 5 Phase 3 Acoramidis trials, 2 Phase 4 are listed. 5 Acoramidis clinical trials are actively recruiting at 39 U.S. sites across 23 states. Most recent activity: NCT07116473 (Dec 2037).

Where to Participate: All Acoramidis Trial Sites in the U.S. (39 sites across 23 states)

Every actively recruiting Acoramidistrial site, sorted by state then city. Each row links to the trial detail page (eligibility, contacts, full study record). Sites no longer enrolling at the location level are excluded. ClinicalTrials.gov / AACT does not provide street-level addresses; the map link uses the facility's geocoded coordinates where available.

StateFacilityCityTrialMap
CAUniversity of California, San Diego (UCSD) - Medical CenterLa Jolla92037NCT06563895Map
CAUniversity of California, Los Angeles (UCLA) - David Geffen School of MedicineLos Angeles90095NCT06563895Map
CAUniversity of California, San Francisco (UCSF)San Francisco94143NCT06563895Map
CAStanford UniversityStanford94305NCT06563895Map
COUniversity of Colorado AnschutzAurora80045NCT06563895Map
CTYale University School of Medicine - Section of CardiologyNew Haven06519NCT06563895Map
DCMedStar Washington Hospital Center - MedStar Heart and Vascular InstituteWashington D.C.20010NCT06563895Map
FLMayo Clinic - JacksonvilleJacksonville32224NCT06563895Map
FLCleveland Clinic FloridaWeston33331NCT06563895Map
GAEmory University School of MedicineAtlanta30322NCT06563895Map
ILJohn H. Stroger, Jr. Hospital of Cook CountyChicago60612NCT06563895Map
ILUniversity of Chicago - Medical CenterChicago60637NCT06563895Map
MDJohns Hopkins UniversityBaltimore21287NCT06563895Map
MDUniversity of Maryland Medical CenterBaltimore21201NCT06563895Map
MABoston University (BU) School of MedicineBoston02118NCT06563895Map
MABrigham and Women's HospitalBoston02115NCT06563895Map
MAMassachusetts General HospitalBoston02114NCT06563895Map
MIHenry Ford Health SystemDetroit48202NCT06563895Map
MNMayo Clinic - RochesterRochester55905NCT06563895Map
MOSt. Luke's Hospital of Kansas CityKansas City64111NCT06563895Map
MOWashington University in St. LouisSt Louis63110NCT06563895Map
NJRutgers-Robert Wood Johnson Medical SchoolNew Brunswick08901NCT06563895Map
NYColumbia University Medical CenterNew York10032NCT06563895Map
NYMount Sinai HospitalNew York10029NCT06563895Map
NYNew York University (NYU) School of Medicine - Langone Medical CenterNew York10016NCT06563895Map
NYLaurelton Heart SpecialistsRosedale11422NCT06563895Map
NCDuke University Medical CenterDurham27710NCT06563895Map
OHCleveland ClinicCleveland44195NCT06563895Map
OROregon Health & Science UniversityPortland97239NCT06563895Map
PAPenn Presbyterian Medical CenterPhiladelphia19104NCT06563895Map
PAUniversity of Pittsburgh Medical Center, Presbyterian HospitalPittsburgh15213NCT06563895Map
SCMedical University of South Carolina (MUSC)Charleston29425NCT06563895Map
SCPrisma Health Cancer InstituteGreenville89605NCT06563895Map
TXNational Neuromuscular Research InstituteAustin78759NCT06563895Map
TXUniversity of Texas SouthwesternDallas75390NCT06563895Map
UTUniversity of UtahSalt Lake City84132NCT06563895Map
VAINOVA Fairfax HospitalFalls Church22042NCT06563895Map
VAVirginia Commonwealth UniversityRichmond23219NCT06563895Map
WAUniversity of Washington Medical CenterSeattle98195NCT06563895Map

Acoramidis clinical trials at a glance: phase × recruitment status

Phaserecruitingactive not recruitingcompletedwithdrawnnot yet recruitingTotal
P122
P3111115
P422
N/A11

Recruiting Acoramidis clinical trials (5)

Studies currently enrolling participants. Click any NCT ID to view the trial detail page (eligibility, sites, contacts).

NCT IDTitlePhaseIndicationEnrollmentStarted
NCT07116473ACT-EARLY OLETo Evaluate the Long-term Safety and Tolerability of Acoramidis in Participants With Newly Diagnosed ATTR-CM (ACT-EARLY OLE)P3Amyloidosis in Transthyretin (TTR)250Nov 2025
NCT06563895ACT-EARLYAcoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) Study in Asymptomatic Carriers of a Pathogenic TTR VariantP3Amyloidosis587May 2025
NCT07235462ACO-REALA Study to Learn About the Use of Acoramidis in Patients With a Heart Condition Called Transthyretin Amyloid Cardiomyopathy (ATTR-CM) in a Real-world SettingTransthyretin Amyloid Cardiomyopathy (ATTR-CM)2,000Oct 2025
NCT07306949ATTR-CMReal-Life Clinical Efficacy of Acoramidis in Participants With ATTR-CM and Association With Cardiac BiomarkersP4Transthyretin-type Cardiac Amyloidosis200Oct 2025
NCT07298044ACO-SWITCHA Study to Learn More About the Change in the Blood Levels of Transthyretin When Participants With Transthyretin Amyloidosis With Cardiomyopathy Switch From Tafamidis to AcoramidisP4Transthyretin Amyloid Cardiomyopathy50Feb 2026

Acoramidis clinical trials by indication

Amyloidosis (3)

NCTAcronymPhaseStatusTitle
NCT06563895ACT-EARLYP3recruitingAcoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) Study in Asymptomatic Carriers of a Pathogenic TTR Variant
NCT03860935ATTRibute-CMP3completedEfficacy and Safety of AG10 in Subjects With Transthyretin Amyloid Cardiomyopathy
NCT04769479P1completedA Single Dose Study to Evaluate the Pharmacokinetics of Acoramidis Modified Release Formulations in Healthy Subjects

Transthyretin Amyloid Cardiomyopathy (1)

NCTAcronymPhaseStatusTitle
NCT07298044ACO-SWITCHP4recruitingA Study to Learn More About the Change in the Blood Levels of Transthyretin When Participants With Transthyretin Amyloidosis With Cardiomyopathy Switch From Tafamidis to Acoramidis

Amyloidosis in Transthyretin (TTR) (1)

NCTAcronymPhaseStatusTitle
NCT07116473ACT-EARLY OLEP3not yet recruitingTo Evaluate the Long-term Safety and Tolerability of Acoramidis in Participants With Newly Diagnosed ATTR-CM (ACT-EARLY OLE)

Transthyretin Amyloid Cardiomyopathy (ATTR-CM) (1)

NCTAcronymPhaseStatusTitle
NCT07235462ACO-REALN/ArecruitingA Study to Learn About the Use of Acoramidis in Patients With a Heart Condition Called Transthyretin Amyloid Cardiomyopathy (ATTR-CM) in a Real-world Setting

Transthyretin-type Cardiac Amyloidosis (1)

NCTAcronymPhaseStatusTitle
NCT07306949ATTR-CMP4recruitingReal-Life Clinical Efficacy of Acoramidis in Participants With ATTR-CM and Association With Cardiac Biomarkers

Amyloid Cardiomyopathy, Transthyretin-Related (1)

NCTAcronymPhaseStatusTitle
NCT04988386AG10P3active not recruitingOpen-Label Safety Study of Acoramidis (AG10) in Symptomatic ATTR Participants

Transthyretin-Related (ATTR) Familial Amyloid Polyneuropathy (1)

NCTAcronymPhaseStatusTitle
NCT04882735AG10P3withdrawnEfficacy and Safety of Acoramidis (AG10) in Subjects with Transthyretin Amyloid Polyneurophathy (ATTRibute-PN)

Healthy (1)

NCTAcronymPhaseStatusTitle
NCT04958135P1completedStudy to Assess the Effect of Food on a Single Dose of Acoramidis in Healthy Adult Participants

Acoramidis pivotal trial highlights (Phase 2/3/4)

Phase-2/3/4 studies with named acronyms — the registration-grade trials most cited in label discussions and Wikipedia.

AcronymNCTPhaseStatusIndicationEnrollmentPubMed
ATTR-CMNCT07306949P4recruitingTransthyretin-type Cardiac Amyloidosis200
ACO-SWITCHNCT07298044P4recruitingTransthyretin Amyloid Cardiomyopathy50
ACT-EARLY OLENCT07116473P3not yet recruitingAmyloidosis in Transthyretin (TTR)250
ACT-EARLYNCT06563895P3recruitingAmyloidosis587
AG10NCT04988386P3active not recruitingAmyloid Cardiomyopathy, Transthyretin-Related389PMID 41911489
AG10NCT04882735P3withdrawnTransthyretin-Related (ATTR) Familial Amyloid Polyneuropathy0
ATTRibute-CMNCT03860935P3completedAmyloidosis632PMID 42110872

Terminated and withdrawn Acoramidis trials (1)

Studies that ended before completion. Reasons are filed in each trial's ClinicalTrials.gov entry.

All Acoramidis trials (10)

Sorted by most recent activity (completion → start → posted date). Each row links to the trial detail page on Hipa.ai.

NCT IDAcronymTitlePhaseStatusEnrollmentSponsorStarted
NCT07116473ACT-EARLY OLETo Evaluate the Long-term Safety and Tolerability of Acoramidis in Participants With Newly Diagnosed ATTR-CM (ACT-EARLY OLE)P3not yet recruiting250Eidos Therapeutics, a BridgeBio companyNov 2025
NCT06563895ACT-EARLYAcoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) Study in Asymptomatic Carriers of a Pathogenic TTR VariantP3recruiting587Eidos Therapeutics, a BridgeBio companyMay 2025
NCT07235462ACO-REALA Study to Learn About the Use of Acoramidis in Patients With a Heart Condition Called Transthyretin Amyloid Cardiomyopathy (ATTR-CM) in a Real-world Settingrecruiting2,000BayerOct 2025
NCT04988386AG10Open-Label Safety Study of Acoramidis (AG10) in Symptomatic ATTR ParticipantsP3active not recruiting389Eidos Therapeutics, a BridgeBio companyOct 2021
NCT07306949ATTR-CMReal-Life Clinical Efficacy of Acoramidis in Participants With ATTR-CM and Association With Cardiac BiomarkersP4recruiting200Alexion Pharmaceuticals, Inc.Oct 2025
NCT07298044ACO-SWITCHA Study to Learn More About the Change in the Blood Levels of Transthyretin When Participants With Transthyretin Amyloidosis With Cardiomyopathy Switch From Tafamidis to AcoramidisP4recruiting50BayerFeb 2026
NCT04882735AG10Efficacy and Safety of Acoramidis (AG10) in Subjects with Transthyretin Amyloid Polyneurophathy (ATTRibute-PN)P3withdrawn0Eidos Therapeutics, a BridgeBio companySep 2021
NCT03860935ATTRibute-CMEfficacy and Safety of AG10 in Subjects With Transthyretin Amyloid CardiomyopathyP3completed632Eidos Therapeutics, a BridgeBio companyMar 2019
NCT04769479A Single Dose Study to Evaluate the Pharmacokinetics of Acoramidis Modified Release Formulations in Healthy SubjectsP1completed14Eidos Therapeutics, a BridgeBio companyMar 2021
NCT04958135Study to Assess the Effect of Food on a Single Dose of Acoramidis in Healthy Adult ParticipantsP1completed18Alexion Pharmaceuticals, Inc.May 2021

Acoramidis clinical trials: frequently asked questions

How many Acoramidis clinical trials are there?
10 Acoramidis clinical trials are catalogued on Hipa.ai, sourced from the AACT mirror of ClinicalTrials.gov. 4 are actively recruiting participants. 3 are marked completed.
Are Acoramidis clinical trials recruiting in 2026?
Yes — 4 Acoramidis trials are actively recruiting in 2026, with 39 U.S. sites across 23 states. See the recruiting trials and the per-state site list further down this page.
What conditions is Acoramidis being studied for?
Acoramidis is being studied for Amyloidosis, Cardiomyopathies, Amyloid Cardiomyopathy, Transthyretin Amyloidosis, Amyloid Cardiomyopathy, Transthyretin-Related and 12 more. The trials are grouped by indication on this page.
What phase is Acoramidis in?
Acoramidis clinical trials span 2 Phase 4, 5 Phase 3, 2 Phase 1. The phase × status matrix at the top of this page breaks down counts by phase and recruitment status.
Who sponsors Acoramidis clinical trials?
The lead sponsor across the most Acoramidis trials is Eidos Therapeutics, a BridgeBio company, with 2 additional lead sponsors listed in the data. Each trial row links to the full study detail page including sponsor information.

Sources and methodology

Trial inventory derived from the AACT mirror of ClinicalTrials.gov. Trials are filtered to those naming Acoramidisas an intervention. Phase, status, enrollment, sponsor, and dates are taken from the source `studies` table; primary indication is the first listed condition. Acronyms are extracted from each trial's brief title where present. PubMed links are populated for trials whose published primary outcomes have been indexed in our evidence cache.

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