Trial results for a study investigating a Targeted Management (TEAM) intervention for Stroke were posted on ClinicalTrials.gov on 2025-08-03, with 276 participants enrolled.
Background
Stroke remains a significant global health concern, particularly in populations with a high prevalence of risk factors such as hypertension. Effective management strategies aimed at reducing these risk factors are crucial for preventing stroke and improving public health outcomes. This study focused on developing and testing an intervention tailored for high-risk Ugandans, where targeted approaches can have a substantial impact on reducing stroke incidence.
Trial design
This completed study, designated as Phase NA, enrolled 276 participants to investigate conditions including Stroke. The trial aimed to refine and then test the effects of the TargetEd MAnageMent (TEAM) intervention in reducing stroke risk factors over a 6-month period. The study compared the TEAM intervention against an Enhanced Treatment as Usual (ETAU) arm.
Key results
The trial reported several key measurements related to systolic blood pressure at 6 months:
- Change From Baseline Systolic Blood Pressure (BP) at 6 Months:
- For the TargEted MAnageMent Intervention (TEAM) group, the mean systolic blood pressure was 145.7 millimeters of mercury (mmHg) (Standard Deviation 21.5).
- For the Enhanced Treatment as Usual (ETAU) group, the mean systolic blood pressure was 141.9 millimeters of mercury (mmHg) (Standard Deviation 18.4).
- Another measurement for the TargEted MAnageMent Intervention (TEAM) group showed a mean systolic blood pressure of 137.4 millimeters of mercury (mmHg) (Standard Deviation 18.1).
- Another measurement for the Enhanced Treatment as Usual (ETAU) group showed a mean systolic blood pressure of 141.1 millimeters of mercury (mmHg) (Standard Deviation 21.9).
What this means
The posted results provide specific systolic blood pressure measurements for both the Targeted Management Intervention (TEAM) and Enhanced Treatment as Usual (ETAU) groups at the 6-month mark. These measurements offer insights into the blood pressure levels observed in participants receiving the respective interventions. Without further comparative analyses or statistical significance data, direct conclusions about the relative efficacy of the TEAM intervention in reducing stroke risk factors cannot be definitively drawn from these raw measurements alone. However, this data contributes to the understanding of observed outcomes in this high-risk Ugandan population.
Source
The information regarding these trial results was obtained from ClinicalTrials.gov, a public database of clinical studies. The results for the study NCT04685408, titled "A TargEted MAnageMent Intervention for Reducing Stroke Risk Factors in High Risk Ugandans", were posted on 2025-08-03 on clinicaltrials.gov.