Trial results investigating perceptual-motor interaction to improve bimanual coordination after stroke were posted on ClinicalTrials.gov on 2025-08-14, with 79 participants enrolled.
Background
Stroke often leads to significant difficulty in using the weaker arm in daily activities, partly due to challenges in engaging both arms interactively and in a coordinated manner. Understanding the nature of these bimanual coordination deficits is crucial for advancing stroke rehabilitation. This study aimed to explore these deficits and test a novel, theory-driven approach to improve interactive bimanual coordination, with the goal of identifying new strategies to enhance the engagement of the weaker arm in coordinated actions.
Trial design
This completed study, designated as an Early Phase 1 trial, enrolled 79 participants. The study investigated Stroke, focusing on the nature of bimanual coordination deficits. It compared measurements between a group of Neurotypical Control participants and Stroke Survivors to test a novel theory-driven approach aimed at improving interactive bimanual coordination.
Key results
The trial reported several key measurements related to the "Maximum Cross-correlation Coefficient" for bimanual coordination, comparing neurotypical controls and stroke survivors. Statistical analysis using ANOVA indicated significant differences between the groups, with a p-value of 0.001.
- For "Maximum Cross-correlation Coefficient":
- Neurotypical Control: mean of 0.989 (Standard Deviation 0.014)
- Stroke Survivors: mean of 0.945 (Standard Deviation 0.064)
- Another measurement for "Maximum Cross-correlation Coefficient":
- Neurotypical Control: mean of 0.995 (Standard Deviation 0.006)
- Stroke Survivors: mean of 0.996 (Standard Deviation 0.005)
- Another measurement for "Maximum Cross-correlation Coefficient":
- Neurotypical Control: mean of 0.985 (Standard Deviation 0.016)
- Stroke Survivors: mean of 0.951 (Standard Deviation 0.05)
- Another measurement for "Maximum Cross-correlation Coefficient":
- Neurotypical Control: mean of 0.998 (Standard Deviation 0.003)
- Stroke Survivors: mean of 0.997 (Standard Deviation 0.003)
- Another measurement for "Maximum Cross-correlation Coefficient":
- Neurotypical Control: mean of 0.957 (Standard Deviation 0.068)
- Stroke Survivors: mean of 0.933 (Standard Deviation 0.065)
- Another measurement for "Maximum Cross-correlation Coefficient":
- Neurotypical Control: mean of 0.998 (Standard Deviation 0.002)
- Stroke Survivors: mean of 0.995 (Standard Deviation 0.006)
What this means
The results from this early phase study highlight measurable differences in bimanual coordination, as indicated by the "Maximum Cross-correlation Coefficient," between stroke survivors and neurotypical controls. The statistically significant findings (p-value of 0.001) suggest that bimanual coordination is indeed affected in stroke survivors. These findings lay groundwork for further investigation into perceptual-motor interaction as a potential avenue for developing new rehabilitation strategies to improve the functional engagement of the weaker arm after stroke.
Source
The information regarding these trial results was obtained from ClinicalTrials.gov, a public database of clinical studies. The results for the study "Perceptual-motor Interaction to Improve Bimanual Coordination After Stroke" (NCT03755076) were posted on 2025-08-14 on clinicaltrials.gov.