Trial results for a study investigating dietary protein patterns in Parkinson's Disease were posted on ClinicalTrials.gov on 2025-06-15, with 12 participants enrolled.
Background
Parkinson's Disease is a progressive neurodegenerative disorder primarily affecting motor function. Management often involves medication, and dietary factors, particularly protein intake, can influence drug efficacy and overall patient health, including skeletal muscle preservation. This pilot study aimed to explore how different dietary protein patterns might impact markers of skeletal muscle health and drug efficacy in individuals with Parkinson's Disease, generating preliminary data in this area.
Trial design
This completed pilot study, designated as Phase NA, enrolled 12 participants with Parkinson Disease. The study's purpose was to generate preliminary data on the impact of dietary protein patterns on markers of skeletal muscle health and drug efficacy. Participants were assigned to either a "Protein Redistribution Diet" or a "Protein Consistent Diet" to investigate their effects on various outcomes.
Key results
The trial reported several key measurements related to changes in motor and total Parkinson symptoms across the two dietary groups:
- Change in Motor Symptoms (Score):
- For the Protein Redistribution Diet, mean changes were 11.27 (Standard Deviation 5.57) and 9.45 (Standard Deviation 5.97).
- For the Protein Consistent Diet, mean changes were 9.58 (Standard Deviation 7.75) and 9.42 (Standard Deviation 4.94).
- Change in Total Parkinson Symptoms (score on a scale):
- For the Protein Redistribution Diet, mean changes were 52.09 (Standard Deviation 20.92) and 47.18 (Standard Deviation 19.15).
- For the Protein Consistent Diet, mean changes were 51.17 (Standard Deviation 21.04) and 48.75 (Standard Deviation 20.52).
What this means
The posted results provide preliminary data on the observed changes in motor and total Parkinson symptoms for individuals with Parkinson's Disease following either a Protein Redistribution Diet or a Protein Consistent Diet. While specific mean scores and standard deviations are reported for these symptom changes, the data does not include comparative analyses or statistical significance between the two dietary approaches. These initial measurements contribute to understanding the potential impact of dietary protein patterns in Parkinson's Disease and may inform the design of future, larger studies.
Source
The information regarding these trial results was obtained from ClinicalTrials.gov, a public database of clinical studies. The results for the study "Optimizing Protein Patterns for Skeletal Muscle Preservation and Sleep in the Medical Management of Parkinson Disease" were posted on 2025-06-15 on clinicaltrials.gov.