Trial results for 'Sing For Your Saunter Part 2 R33', investigating rhythm-based walking interventions in Parkinson's Disease patients, were posted on ClinicalTrials.gov on 2026-04-02. The study enrolled 74 participants.
Background
Parkinson's Disease is a progressive neurodegenerative disorder characterized by motor symptoms such as tremor, rigidity, bradykinesia, and postural instability, which significantly impact gait and balance. Current treatments primarily focus on managing symptoms, but non-pharmacological interventions, particularly those involving movement and rhythm, are explored to improve motor function and quality of life. Rhythm-based walking interventions, such as walking to music or singing, are being investigated as potential strategies to enhance gait performance in individuals with Parkinson's Disease.
Trial design
This completed Phase 2 study, titled 'Sing For Your Saunter Part 2 R33', enrolled 74 participants with Parkinson Disease. The trial aimed to compare two rhythm-based walking interventions to enhance gait. Participants trained for 12 weeks on the use of rhythms, specifically walking to music and walking while singing. The main questions the study aimed to answer were how rhythm-based training influences walking performance and how brain activity changes following such training. The investigators compared the effects of training with music to training with singing, with key measurements reported for 'Self Cueing' and 'External Cueing' groups.
Key results
The trial results include key measurements for gait speed and brain activity. For 'Gait Speed', measured in meters per second:
- For the 'Self Cueing' group, mean gait speeds were 1.09 (Standard Deviation 0.20) and 1.15 (Standard Deviation 0.21) meters per second.
- For the 'External Cueing' group, mean gait speeds were 1.04 (Standard Deviation 0.23) and 1.08 (Standard Deviation 0.22) meters per second.
For 'MRI Bold Beta Weights', measured in arbitrary units:
- For the 'Self Cueing' group, mean beta weights were -0.892 (Standard Deviation 0.323), -0.854 (Standard Deviation 0.277), -0.018 (Standard Deviation 0.197), and 0.060 (Standard Deviation 0.186).
- For the 'External Cueing' group, mean beta weights were -0.764 (Standard Deviation 0.323), -0.674 (Standard Deviation 0.378), -0.023 (Standard Deviation 0.210), and -0.093 (Standard Deviation 0.156).
What this means
The posted results provide specific measurements for gait speed and brain activity in individuals with Parkinson's Disease undergoing rhythm-based walking interventions. The 'Self Cueing' group generally demonstrated slightly higher mean gait speeds compared to the 'External Cueing' group across the reported measurements. The MRI Bold Beta Weights offer insights into brain activity changes. These findings contribute to understanding the physiological and neurological impacts of different rhythm-based approaches on motor function in Parkinson's Disease, potentially informing future rehabilitation strategies aimed at improving walking performance.
Source
The information regarding these trial results was obtained from ClinicalTrials.gov, a public database of clinical studies. The results for the study NCT06115382, titled 'Sing For Your Saunter Part 2 R33', were posted on 2026-04-02 on clinicaltrials.gov.