Trial results for Amped-PD, investigating Parkinson's Disease, were posted on ClinicalTrials.gov on 2025-05-31, with 44 participants enrolled.
Background
Parkinson's Disease (PD) is a progressive neurodegenerative disorder characterized by motor and non-motor symptoms. Regular, habitual exercise is a critical component of its long-term management. However, PD-specific challenges, such as slow and diminished movements, variable step timing, depression, and apathy, collectively hinder physical activity. Rhythmic auditory stimulation (RAS) is a rehabilitation technique that couples auditory cues with movement. Walking with RAS has been shown to benefit walking rhythmicity, quality, and speed, making it a potentially advantageous method for promoting moderate intensity walking activity.
Trial design
This completed study, designated as Phase NA, enrolled 44 participants to investigate Parkinson Disease. The trial evaluated the Amped-PD intervention, which utilizes rhythmic auditory stimulation, against an Active-Control group. The study aimed to amplify physical activity through music in individuals with Parkinson's Disease.
Key results
The trial reported several key measurements related to physical activity and step counts:
- Physical Activity Based on the Amount of Moderate Intensity Walking (minutes of moderate intensity walking):
- For the Amped-PD group, a mean of 9.45 (Standard Deviation 9.39) minutes was observed.
- For the Active-Control group, a mean of 16.17 (Standard Deviation 18.08) minutes was observed.
- For the Amped-PD group, a mean of 32.83 (Standard Deviation 10.14) minutes was observed.
- For the Active-Control group, a mean of 23.08 (Standard Deviation 12.09) minutes was observed.
- For the Amped-PD group, a mean of 30.30 (Standard Deviation 11.45) minutes was observed.
- For the Active-Control group, a mean of 24.15 (Standard Deviation 15.23) minutes was observed.
- For the Amped-PD group, a mean of 6.85 (Standard Deviation 6.48) minutes was observed.
- For the Active-Control group, a mean of 13.22 (Standard Deviation 9.62) minutes was observed.
- Step Activity Based on Daily Step Counts (steps):
- For the Amped-PD group, a mean of 8812 (Standard Deviation 3453) steps was observed.
- For the Active-Control group, a mean of 10311 (Standard Deviation 3497) steps was observed.
- For the Amped-PD group, a mean of 12155 (Standard Deviation 3127) steps was observed.
- For the Active-Control group, a mean of 10483 (Standard Deviation 3751) steps was observed.
What this means
The posted results provide detailed measurements of physical activity and daily step counts for participants with Parkinson's Disease in both the Amped-PD and Active-Control groups. The data offers insights into how rhythmic auditory stimulation may influence various aspects of physical activity levels. The varied outcomes across different measurements of moderate intensity walking and step counts suggest that the impact of the Amped-PD intervention may differ depending on the specific activity metric and measurement context. These measurements contribute to the understanding of physical activity patterns in individuals with Parkinson's Disease undergoing such interventions.
Source
The information regarding these trial results was obtained from ClinicalTrials.gov, a public database of clinical studies. The results for the study NCT05421624, titled "Amped-PD: Amplifying Physical Activity Through Music in Parkinson Disease", were posted on 2025-05-31 on clinicaltrials.gov.