Trial results for a study investigating tremor suppression in Parkinson's Disease and Essential Tremor were posted on ClinicalTrials.gov on 2025-10-27, reporting a mean tremor suppression of 62.4%.
Background
Individuals experiencing tremors, a common symptom in conditions like Parkinson's Disease and Essential Tremor, often face significant difficulties performing activities of daily living due to involuntary muscle oscillations in the hands and arms. Current approaches to manage tremors include medication, surgical interventions, assistive devices, and lifestyle modifications. However, these solutions can present drawbacks such as high costs and unwanted side effects. Functional electrical stimulation (FES) has emerged as a potential alternative for tremor suppression, and its integration with technologies like ultrasound imaging is being explored to enhance its effectiveness.
Trial design
This completed study, designated as Phase NA, enrolled 12 participants diagnosed with Parkinson Disease and Essential Tremor. The trial focused on the analysis and suppression of tremor during grasping movements, utilizing ultrasound imaging in conjunction with electrical stimulation.
Key results
The trial reported several key measurements related to tremor modeling, frequency detection, and suppression:
- Tremor Model Accuracy (Normalized RMSE (%)):
- A mean of 24 (Standard Deviation 4.49) was observed in the Tremor Group.
- Another mean of 21 (Standard Deviation 2.66) was observed in the Tremor Group.
- Ultrasound Imaging Based Frequency Detection (Error percentage (%)):
- A mean of 8.9 (Standard Deviation 0.57) was observed in the Tremor Group.
- Another mean of 6.4 (Standard Deviation 0.39) was observed in the Tremor Group.
- Tremor Suppression (Percentage) (Percentage Suppression):
- A mean of 62.4 (Standard Deviation 18.93) was observed in the Tremor Group.
What this means
The posted results indicate that the investigated approach, combining ultrasound imaging and electrical stimulation, achieved a notable mean tremor suppression of 62.4% in participants with Parkinson's Disease and Essential Tremor. The reported accuracy in tremor modeling and frequency detection suggests the potential for this technology to precisely identify and mitigate involuntary movements. These findings contribute to the understanding of non-pharmacological interventions for tremor management, offering a basis for further development and clinical evaluation of integrated stimulation and imaging techniques.
Source
The information regarding these trial results was obtained from ClinicalTrials.gov, a public database of clinical studies. The results for the study NCT05308368, titled "Analysis and Suppression of Tremor During Grasp Using Ultrasound Imaging and Electrical Stimulation", were posted on 2025-10-27 on clinicaltrials.gov.