Trial results for a study investigating context-aware freezing of gait mitigation in Parkinson's Disease were posted on ClinicalTrials.gov on 2025-08-22, with 12 participants enrolled.
Background
People with Parkinson's Disease (PD) often experience freezing of gait (FoG), a challenging walking problem where individuals feel their feet are stuck to the floor. FoG can significantly impair daily activities and is typically not well-addressed by conventional drug treatments for PD. Research has explored alternative approaches, such as vibration therapy, as a potential method to improve FoG. This study aimed to test the safety, tolerability, and effectiveness of a wearable device designed to recognize FoG and deliver a signal.
Trial design
This completed study enrolled 12 participants with Parkinson Disease. The trial investigated the use of a wearable device (UG motion sensor, described as the size of a watch) that was designed to recognize FoG and then send a signal to another small wearable device, delivering vibration therapy. The purpose was to test the safety, tolerability, and effectiveness of this approach.
Key results
The trial reported several key measurements related to freezing of gait (FoG) episodes and their duration, all observed within the Vibration Therapy group:
- Number of Freezing of Gait (FoG) Episodes:
- A mean of 3.75 (Standard Error 0.765) number of freezes was observed.
- Another mean of 5.17 (Standard Error 0.765) number of freezes was observed.
- A mean of 4.0 (Standard Error 1.205) number of freezes was observed.
- Another mean of 3.63 (Standard Error 1.205) number of freezes was observed.
- Duration of Freezing of Gait (FoG) Episodes:
- A mean of 47.67 (Standard Error 12.06) minutes was observed.
- Another mean of 52.14 (Standard Error 12.06) minutes was observed.
- A mean of 34.565 (Standard Error 17.2) minutes was observed.
- Another mean of 43.505 (Standard Error 17.2) minutes was observed.
What this means
The posted results provide specific mean values and standard errors for the number and duration of freezing of gait episodes observed in a small group of Parkinson's Disease patients using a context-aware vibration therapy device. As this was a small, completed study without a comparative arm or baseline data provided in the results summary, these measurements offer initial descriptive data on the observed FoG characteristics under the intervention. Further research would be needed to establish the efficacy or comparative benefit of this approach.
Source
The information regarding these trial results was obtained from ClinicalTrials.gov, a public database of clinical studies. The results for the study NCT04746846, titled "SCH: Context-aware Freezing of Gait Mitigation in Real-world Setting", were posted on 2025-08-22 on clinicaltrials.gov.