Trial results for Platelet Rich Plasma (PRP) injections in osteoarthritis were posted on ClinicalTrials.gov on 2025-05-23. The study reported that 25 participants experienced successful knee pain improvement and 12 participants experienced successful knee function improvement over 6 months following PRP injections.

Background

Knee Osteoarthritis (OA) is a significant cause of disability, particularly affecting Veterans at higher rates and younger ages. For individuals with symptomatic early knee OA who are not yet candidates for knee replacement surgery, knee injections are a common treatment option. Platelet Rich Plasma (PRP) injections have garnered interest for their potential to improve pain and function in patients with knee OA, with basic science studies suggesting they may also stimulate repair responses in articular cartilage.

Trial design

This completed study enrolled 90 participants with Osteoarthritis. The trial investigated the effects of Platelet Rich Plasma (PRP) injections. The overall status of the trial is COMPLETED.

Key results

The study reported on key measurements for participants who received Platelet Rich Plasma (PRP) injections:

What this means

The results indicate that a subset of participants with osteoarthritis experienced improvements in knee pain and function following PRP injections. Specifically, 25 out of 90 participants reported successful pain improvement, and 12 reported successful function improvement over a six-month period. These findings contribute to the understanding of PRP as a treatment option for symptomatic early knee osteoarthritis, particularly for those not yet eligible for surgical interventions.

Source

The information for these trial results was obtained from ClinicalTrials.gov, a public database of clinical studies. The results for the study NCT03460236, titled "Precision Assessment of Platelet Rich Plasma for Joint Preservation", were posted on 2025-05-23 on clinicaltrials.gov.