Precision Assessment of Platelet Rich Plasma for Joint Preservation

Part of paid clinical trials in Palo Alto, California.

Sponsor
VA Office of Research and Development
Study ID
NCT03460236
Status
Completed

Conditions

Eligibility Criteria

Sex
ALL
Age
30 Years - N/A
Healthy Volunteers
Not accepted

Study Details

Knee Osteoarthritis (OA) is a leading cause of premature disability in Veterans who develop knee OA at higher rates and younger ages than the population in general. For those with symptomatic early knee OA, who are years to decades away from meeting clinical indications for knee replacement surgery, knee injections have been a key treatment option. In recent years, platelet rich plasma (PRP) injections have gained increasing attention for improving pain and function in patients with knee OA. Basic science studies also suggest that PRP may also potentially stimulate repair responses to articular cartilage. However, the mechanisms of action of PRP in the treatment of knee OA are unknown. Because autologous blood is used, the PRP composition differs between patients. It is also unknown whether these differences in PRP composition affect clinical outcomes. This study will address these gaps and provide critical new and objective information on PRP treatment effects in Veterans and additional women with early knee OA important to improving clinical use of this new treatment.

Key Dates

Start date
Apr 2, 2018
Status verified
May 2025
Primary completion
Mar 29, 2024
Completion
Mar 31, 2024

Study Design

Enrollment
90 participants (actual)

Arms

  • Arm: PRP
    Symptomatic early knee osteoarthritis subjects who have elected to receive PRP treatment.

Primary Outcome Measure

Number of Participants With Successful Knee Pain Improvement Over 6 Months Following PRP Injections [ Time Frame: Baseline to 6 months ]

Locations (1)

FacilityCityStateZIPSite coordinators
VA Palo Alto Health Care System, Palo Alto, CAPalo AltoCalifornia94304-1207-

Find similar trials in Palo Alto, CA

By condition
Osteoarthritis (other)
By specialty
OrthopedicsMusculoskeletal disorders
By research site
VA Palo Alto Health Care System, Palo Alto, CA· Palo Alto, CA

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