Trial results for a study investigating the relationship between physical activity, metabolic function, and appetite in adolescents with Obesity were posted on ClinicalTrials.gov on 2026-02-12, with 31 participants enrolled.
Background
Obesity in adolescents is a significant public health concern, often associated with metabolic dysfunction and dysregulated appetite. Current approaches to managing adolescent obesity frequently focus on body weight status. This study aimed to explore an alternative perspective, hypothesizing that high levels of regular moderate-to-vigorous physical activity (MVPA) could lead to an enhanced metabolic phenotype and proper regulation of appetite, independent of body weight status. Understanding these relationships is crucial for developing effective interventions.
Trial design
This completed study, designated as Phase NA, enrolled 31 participants to investigate conditions including Obesity, Energy Balance, Appetite, Metabolism, and Insulin Sensitivity. The trial aimed to quantify the relationship between physical activity, metabolic function, and appetite in adolescents. Participants were randomly assigned to either a structured-exercise group or a newsletter control group for three months.
Key results
The trial reported key measurements related to subjective and adjusted appetite scores:
- Appetite- Subjective (score*minute):
- In the Structured Exercise group, the least squares mean was 6282 (Standard Error 1075).
- In the Newsletter Control group, the least squares mean was 8738 (Standard Error 1171).
- Appetite- Adjusted (score on a scale*min):
- In the Structured Exercise group, the least squares mean was 7482 (Standard Error 1094).
- In the Newsletter Control group, the least squares mean was 8269 (Standard Error 1094).
What this means
The results suggest that a structured exercise intervention in adolescents with obesity may lead to lower subjective and adjusted appetite scores compared to a control group. Specifically, participants in the structured exercise group reported lower appetite scores across both measurements. This data supports the hypothesis that physical activity can influence appetite regulation, potentially offering a non-pharmacological approach to managing appetite in adolescents with obesity. Further research would be needed to understand the clinical significance of these differences and long-term outcomes.
Source
The information regarding these trial results was obtained from ClinicalTrials.gov, a public database of clinical studies. The results for the study NCT05443347, titled "Activity, Adiposity, and Appetite in Adolescents 2 Intervention", were posted on 2026-02-12 on clinicaltrials.gov.