Trial results for the study "Eating Mindfully to Prevent Weight Regain" were posted on ClinicalTrials.gov on 2025-11-25, involving 48 participants. The Mindfulness Orientated Recovery Enhancement (MORE) intervention group experienced a mean weight gain of 2.45 kilograms, while the control group showed a mean weight loss of 3.78 kilograms.
Background
Obesity is a complex, chronic condition, and a significant challenge for individuals who have achieved weight loss is preventing subsequent weight regain. Effective strategies are crucial for maintaining long-term weight management. Mindfulness-based interventions have been explored as a potential approach to address eating behaviors and emotional regulation, which can influence weight outcomes. This study aimed to evaluate the effectiveness of such an intervention specifically designed to prevent weight regain in adults who had previously lost weight.
Trial design
This completed study, designated as Phase NA, enrolled 48 participants. The trial investigated conditions including Weight Loss, Weight Gain, Eating Behavior, Obesity, and Bariatric Surgery Candidate. The overall objective was to evaluate the efficacy of a mindfulness-based intervention, specifically the Mindfulness Orientated Recovery Enhancement (MORE) Intervention, to prevent weight regain in weight-reduced adults. The intervention was compared against a Control Intervention group.
Key results
The trial reported several key measurements:
- Changes in Body Weight:
- For the Mindfulness Orientated Recovery Enhancement (MORE) Intervention group, the mean change was a gain of 2.45 kilograms (Standard Deviation 1.02).
- For the Control Intervention group, the mean change was a loss of -3.78 kilograms (Standard Deviation 1.2).
- Ways of Savoring Checklist (WOSC) (score on a scale):
- The Mindfulness Orientated Recovery Enhancement (MORE) Intervention group had a mean score of 16.2 (Standard Error 0.51).
- The Control Intervention group had a mean score of 17.1 (Standard Error 0.55).
- Dietary Restraint (score on a scale):
- The Mindfulness Orientated Recovery Enhancement (MORE) Intervention group had a mean score of 7.81 (Standard Error 0.83).
- The Control Intervention group had a mean score of 7.23 (Standard Error 0.88).
- Dietary Disinhibition (score on a scale):
- The Mindfulness Orientated Recovery Enhancement (MORE) Intervention group had a mean score of 5.14 (Standard Error 0.67).
- The Control Intervention group had a mean score of 4.60 (Standard Error 0.67).
- Interoceptive Awareness (score on a scale):
- The Mindfulness Orientated Recovery Enhancement (MORE) Intervention group had a mean score of 24.0 (Standard Error 0.94).
- The Control Intervention group had a mean score of 22.3 (Standard Error 1.04).
- Hedonic Hunger (score on a scale):
- The Mindfulness Orientated Recovery Enhancement (MORE) Intervention group had a mean score of 12.84 (Standard Error 0.74).
- The Control Intervention group had a mean score of 14.61 (Standard Error 0.82).
Key analyses using Linear Regression reported p-values of 0.001, 0.22, 0.62, 0.21, and 0.11 for various outcomes.
What this means
The results indicate that the mindfulness-based intervention, as implemented in this study, did not prevent weight regain in weight-reduced adults. In fact, participants in the intervention group experienced a mean weight gain, while those in the control group, without the specific mindfulness intervention, showed a mean weight loss. This suggests the intervention did not achieve its primary objective of preventing weight regain. While one linear regression analysis showed a statistically significant p-value of 0.001, the context for this specific finding relative to the overall weight outcomes is not detailed. Other analyses did not reach statistical significance. The data also provides insights into changes in various psychological and behavioral metrics related to eating, such as savoring, dietary restraint, disinhibition, interoceptive awareness, and hedonic hunger, which could inform future research into behavioral interventions for weight management.
Source
The information regarding these trial results was obtained from ClinicalTrials.gov, a public database of clinical studies. The results for the study NCT04847843, titled "Eating Mindfully to Prevent Weight Regain", were posted on 2025-11-25 on clinicaltrials.gov.