Trial results for the study “Presessions for the National Diabetes Prevention Program” were posted on ClinicalTrials.gov on 2025-09-05, investigating interventions for conditions including Obesity. The Pre-NDPP group achieved a mean weight loss of 3.1%.
Background
Obesity is a significant public health challenge, often associated with conditions such as prediabetic states and gestational diabetes. The National Diabetes Prevention Program (NDPP) is an established, evidence-based intervention designed to promote weight loss and prevent type 2 diabetes. However, participant attendance in the NDPP has been a persistent issue, leading to suboptimal weight loss outcomes, particularly among Hispanic, non-Hispanic Black, and low-income non-Hispanic White participants. An innovative pre-session enhancement to the NDPP, termed Pre-NDPP, was developed to address these attendance and engagement challenges, aiming to improve overall weight loss efficacy.
Trial design
This completed study, designated as Phase NA, enrolled 483 participants. The trial investigated conditions including Prediabetic State, Obesity, and Gestational Diabetes. The intervention studied was the Pre-NDPP, an enhancement designed to improve engagement and outcomes in the National Diabetes Prevention Program. The comparator arm was the Usual Care NDPP.
Key results
The trial reported key measurements for weight loss in both intervention and comparator groups:
- For the Pre-NDPP group, the mean weight loss was 3.1% (Standard Deviation 6.7 % of weight loss).
- For the Usual Care NDPP group, the mean weight loss was 2.8% (Standard Deviation 6.0 % of weight loss).
What this means
The posted results indicate that the Pre-NDPP intervention led to a slightly higher mean percentage of weight loss compared to the usual care NDPP. While the difference in mean weight loss between the two groups was modest, these findings suggest that the pre-session enhancement may contribute to improved outcomes in weight management for individuals at risk of type 2 diabetes. This could have implications for strategies aimed at enhancing participant engagement and effectiveness within established prevention programs.
Source
The information regarding these trial results was obtained from ClinicalTrials.gov, a public database of clinical studies. The results for the study NCT04022499, titled “Presessions for the National Diabetes Prevention Program”, were posted on 2025-09-05 on clinicaltrials.gov.