Trial results for a study evaluating different messaging strategies and incentives to assess lung cancer screening eligibility were posted on ClinicalTrials.gov on 2025-05-31. The study enrolled 6125 participants, with full survey completion rates ranging from 335 to 402 participants across 12 distinct messaging and incentive arms.
Background
Lung cancer remains a leading cause of cancer-related mortality globally. Early detection through lung cancer screening (LCS) using low-dose computed tomography (LDCT) has been shown to reduce mortality in high-risk individuals. However, the uptake of LCS remains suboptimal, partly due to challenges in effectively identifying eligible individuals and engaging them in screening programs. Understanding how different communication approaches and incentives influence response rates to eligibility assessment tools is crucial for improving screening participation and ultimately enhancing early detection efforts for lung cancer.
Trial design
This completed study, identified as Phase NA, enrolled 6125 participants with Lung Cancer. The primary purpose of the study was to evaluate if different messaging impacts response rates to a brief survey, known as the simplified eligibility tool, which is designed to estimate pack-year eligibility for lung cancer screening. The trial explored various combinations of introductory messages (A, B, C), tobacco use messages (A, B), and the presence or absence of an incentive, creating 12 distinct study arms. The goal was to inform strategies for increasing response rates to such tools in future interventions aimed at boosting LCS.
Key results
The trial measured full survey completion across its 12 study arms:
- For Arm 1 (Introductory Message A + Tobacco Use Message A + Incentive), 358 participants completed the full survey.
- For Arm 2 (Introductory Message A + Tobacco Use Message A), 381 participants completed the full survey.
- For Arm 3 (Introductory Message A + Tobacco Use Message B + Incentive), 383 participants completed the full survey.
- For Arm 4 (Introductory Message A + Tobacco Use Message B), 389 participants completed the full survey.
- For Arm 5 (Introductory Message B + Tobacco Use Message A + Incentive), 372 participants completed the full survey.
- For Arm 6 (Introductory Message B + Tobacco Use Message A), 399 participants completed the full survey.
- For Arm 7 (Introductory Message B + Tobacco Use Message B + Incentive), 386 participants completed the full survey.
- For Arm 8 (Introductory Message B + Tobacco Use Message B), 402 participants completed the full survey.
- For Arm 9 (Introductory Message C + Tobacco Use Message A + Incentive), 335 participants completed the full survey.
- For Arm 10 (Introductory Message C + Tobacco Use Message A), 397 participants completed the full survey.
- For Arm 11 (Introductory Message C + Tobacco Use Message B + Incentive), 373 participants completed the full survey.
- For Arm 12 (Introductory Message C + Tobacco Use Message B), 366 participants completed the full survey.
What this means
The posted results indicate that different messaging strategies and the inclusion of an incentive had varying impacts on the completion rates of a lung cancer screening eligibility survey. With completion numbers ranging from 335 to 402 participants across the 12 evaluated arms, the study suggests that the specific design of introductory messages, tobacco use messages, and the presence of an incentive can influence participant engagement. These findings provide valuable insights for public health initiatives and future intervention studies aiming to optimize communication strategies to increase response rates to eligibility tools, thereby potentially improving lung cancer screening uptake and early detection efforts.
Source
The information regarding these trial results was obtained from ClinicalTrials.gov, a public database of clinical studies. The results for the study NCT06133816, titled "Lung Cancer Screening Eligibility Assessment", were posted on 2025-05-31 on clinicaltrials.gov.