Trial results for a one-fraction simulation-free treatment with CT-guided stereotactic adaptive radiotherapy for patients with lung cancer were posted on 2026-05-01. The study demonstrated the feasibility of a streamlined workflow, with 8 out of 10 participants successfully completing the treatment delivery.
Background
Stereotactic body radiotherapy (SBRT) is a well-established treatment for patients with medically inoperable or high-risk operable early-stage non-small cell lung cancer (NSCLC). Its application has also expanded to include the treatment of lung metastases in patients with oligometastatic disease. Despite SBRT being a powerful therapeutic option for lung tumors, patient access to specialized treatment centers can be limited, particularly for those residing far from such facilities. This geographic barrier can persist even for patients undergoing one-fraction lung SBRT, as the typical workflow involves a consult, CT simulation, and then the treatment itself, which can be time-consuming and require multiple visits.
Trial design
This completed trial, which did not specify a traditional phase (Phase NA), enrolled 10 participants. The study focused on patients with Lung Cancer and Oligometastatic Lung Tumor. The intervention investigated was a one-fraction simulation-free treatment utilizing CT-guided stereotactic adaptive radiotherapy, designed to simplify the treatment process. The primary objective was to assess the feasibility of a "ONE STOP" workflow, measured by the number of participants who successfully completed the workflow through treatment delivery.
Key results
The primary outcome measured the feasibility of the "ONE STOP" workflow for one-fraction SBRT. For the group receiving One Fraction SBRT, the number of participants with successful completion of the workflow through treatment delivery was 8 participants.
What this means
The findings from this trial indicate that a "ONE STOP" workflow for CT-guided stereotactic adaptive radiotherapy is feasible for patients with lung cancer and oligometastatic lung tumors. With 8 out of 10 participants successfully completing the streamlined process, this approach could potentially reduce the logistical burden on patients and improve access to SBRT, especially for those in areas with limited access to specialized treatment centers. This simplified workflow may offer a more efficient treatment pathway compared to conventional SBRT protocols that typically require multiple appointments for consultation, simulation, and treatment.
Source
The information regarding these trial results was obtained from ClinicalTrials.gov, a public database of clinical studies. The results for study NCT06236516, titled "One Fraction Simulation-Free Treatment With CT-Guided Stereotactic Adaptive Radiotherapy for Patients With Oligometastatic and Primary Lung Tumors", were posted on 2026-05-01 on clinicaltrials.gov.