Trial results for a study evaluating a new cone-beam CT scanner for image-guided radiotherapy, relevant for conditions including Breast Cancer, were posted on ClinicalTrials.gov on 2026-01-06, with 41 participants enrolled.
Background
Image-guided radiotherapy (IGRT) is a critical component of modern cancer treatment, aiming to precisely deliver radiation while minimizing damage to surrounding healthy tissues. Cone-beam computed tomography (CBCT) scanners are widely used in IGRT to provide on-couch imaging, allowing for accurate patient positioning and verification of target volumes before and during treatment. Enhancements in CBCT technology, particularly concerning image quality and the accuracy of dose calculations, are crucial for improving the efficacy and safety of radiotherapy for various cancers, including head and neck, lung, breast, abdominal, and pelvic cancers.
Trial design
This completed feasibility study, designated as Phase NA, enrolled 41 participants to investigate the image quality of a new, high-performance cone-beam CT scanner used for on-couch imaging during radiotherapy treatments. The study included participants with Head and Neck Cancer, Lung Cancer, Breast Cancer, Abdominal Cancer, and Pelvic Cancer. The primary objective was to evaluate the image quality of the novel CBCT system.
Key results
The trial reported several key measurements related to image quality and dose calculation accuracy, primarily focusing on head and neck imaging:
- For Image Quality in Head/Neck Imaging, median standard deviation of HU values were reported as 6.6, 9.8, 11.2, 8.9, 7.1, and 7.6 units.
- For Accuracy of Radiation Dose Calculation on HyperSight CBCT in Head/Neck Imaging, reported values were 1.1 Gy and 6.5 Gy.
- For Qualitative Assessment of Novel CBCT Images for Contouring Organs at Risk in Head/Neck Images, results showed 47% evaluations and 70% evaluations.
What this means
The posted results provide specific data on the performance characteristics of a new cone-beam CT scanner in the context of image-guided radiotherapy. The reported median standard deviation of HU values for image quality and the dose calculation accuracy figures offer quantitative insights into the system's capabilities. Additionally, the qualitative assessment suggests the potential for improved contouring of organs at risk. These findings are valuable for clinicians and researchers involved in radiation oncology, contributing to the understanding of how advanced CBCT technology can enhance precision in radiotherapy planning and delivery across a range of cancer types.
Source
The information regarding these trial results was obtained from ClinicalTrials.gov, a public database of clinical studies. The results for the study NCT05524454, titled "Evaluation of a Cone-beam CT Scanner for Image Guided Radiotherapy", were posted on 2026-01-06 on clinicaltrials.gov.