Trial results for a study investigating improved cancer on-treatment symptom management were posted on ClinicalTrials.gov on 2025-09-25, with 104 participants enrolled.
Background
Patient-reported outcome measures (PROMs) are direct reports from patients about their health status, uninfluenced by clinicians. Research has shown PROMs can more accurately reflect a patient's daily health compared to physician-reported measures. The IMPROVE pilot study aimed to assess whether patient symptom reporting during definitive-intent radiotherapy could lead to earlier and better detection of treatment toxicity in patients with cancer.
Trial design
This completed study enrolled 104 participants with conditions including Cancer, Thoracic Neoplasms, Gastrointestinal Cancer, and Lung Cancer. The trial focused on evaluating if patient symptom reporting during definitive-intent radiotherapy allows earlier and improved detection of treatment toxicity, as part of an effort to improve cancer on-treatment symptom management.
Key results
The trial reported several key measurements related to changes in physician-assessed burden scores and symptom management:
- For participants with a change in their physician-assessed burden score, counts of 43, 32, and 25 participants were observed.
- For participants with changes in the management of on-treatment symptoms, counts of 29, 39, and 19 participants were observed.
What this means
The posted results provide descriptive data on the number of participants who experienced changes in physician-assessed burden scores and changes in the management of their on-treatment symptoms. As a pilot study, these findings describe the proportions of patients with cancer who experienced these changes when treated with definitive-intent radiotherapy, contributing to the understanding of symptom management strategies.
Source
The information regarding these trial results was obtained from ClinicalTrials.gov, a public database of clinical studies. The results for the study NCT04589247, titled "Improving Cancer On-treatment Symptom Management", were posted on 2025-09-25 on clinicaltrials.gov.