Trial results for a study investigating a multi-level intervention to reduce substance use stigma in HIV prevention and care were posted on ClinicalTrials.gov on 2026-01-14. The study enrolled 51 participants, exploring provider-based stigma with mean scores on the Social Distance Scale of 9.09 and 11.89.
Background
Substance use stigma remains a significant barrier in healthcare, particularly for individuals living with or at risk of HIV. This stigma can negatively impact patient-provider relationships, hinder access to care, and compromise the effectiveness of HIV prevention and treatment efforts. Addressing provider-based stigma is crucial for improving health outcomes and ensuring equitable access to services for patients with substance use disorders in the context of HIV.
Trial design
This completed study, identified as Phase NA, enrolled 51 participants. The trial focused on conditions including Social Stigma, Substance Use Disorders, HIV Infections, and Physician-Patient Relations. The intervention aimed to develop a multi-level substance use stigma intervention leveraging education and organizational policy to address structural drivers of stigma and stigmatizing professional attitudes and behaviors. The study explored various provider-based stigma measures within a 'Training Group'.
Key results
The trial reported several key measurements and analyses for the 'Training Group':
- For Provider-based Stigma (Social Distance Scale), mean scores were 9.09 and 11.89 on a scale.
- For Provider-based Stigma (Medical Condition Regard Scale), mean scores were 22.70 and 25.03 on a scale.
- For Provider-based Stigma (Planned Behavior Measure Assessing Intention to Help Patients Who Use Drugs), mean scores were 3.19 and 3.57 on a scale.
- The number of participants who completed focus groups on training feasibility was 5.
- The number of participants who completed qualitative interviews on policy feasibility was 21.
Key analyses using a 2-sided t-test reported p-values of 0.001, 0.007, and 0.136.
What this means
The posted results provide initial data on provider-based stigma and intentions to help patients who use drugs in the context of HIV care. The reported mean scores on various scales offer insights into the current state or changes in professional attitudes within the 'Training Group'. The completion of focus groups by 5 participants and qualitative interviews by 21 participants indicates engagement with the qualitative components of the intervention planning. The presence of statistically significant p-values (e.g., 0.001, 0.007) suggests that certain aspects of the intervention or observed changes warrant further investigation, though the specific outcomes these p-values relate to are not detailed in the summary data.
Source
The information for this condition update was sourced from ClinicalTrials.gov, a public database of clinical studies. The trial results for NCT05925374, titled "Planning a Multi-Level Intervention to Reduce Substance Use Stigma in HIV Prevention and Care", were posted on 2026-01-14 on clinicaltrials.gov.