Trial results for a study evaluating a new approach to post-discharge HIV care were posted on ClinicalTrials.gov on 2025-08-07, involving 97 participants and reporting on post-discharge visits and mortality.
Background
Early post-discharge mortality is a significant concern among Zambians living with HIV who have been admitted to the hospital. This elevated mortality rate may stem from missed opportunities in the continuum of post-discharge care, including inadequate follow-up and challenges with treatment adherence. Addressing these gaps in care coordination and support after hospitalization is crucial for improving patient outcomes and reducing mortality in this vulnerable population.
Trial design
This completed study, designated as Phase NA, enrolled 97 participants. The trial focused on individuals with HIV/AIDS who experienced Hospitalization, addressing challenges related to Transitions of Care and the presence of Opportunistic Infections. The investigators developed and piloted a new approach to post-discharge HIV care, specifically a Community Health Worker Post-Discharge Intervention, with the goal of improving care coordination and treatment adherence. No specific primary outcomes were listed, and the study did not specify comparator arms, indicating a single-arm design.
Key results
The trial results provided several key measurements for the Community Health Worker Post-Discharge Intervention group:
- For "Post-Discharge Visits," the count of participants was 92.
- For "Comprehensive Post-Discharge Visits," the count of participants was 67.
- For "Mortality," one reported count of participants was 77.
- For "Mortality," another reported count of participants was 19.
- For "Mortality," a third reported count of participants was 1.
What this means
The posted results from this pilot study provide initial data on a new approach to post-discharge HIV care involving community health workers. The high number of participants completing "Post-Discharge Visits" (92 out of 97 enrolled) and "Comprehensive Post-Discharge Visits" (67 participants) suggests that the intervention may be effective in facilitating patient re-engagement with care after hospitalization. While multiple counts for "Mortality" were reported (77, 19, and 1 participants), the specific context or timeframes for these distinct figures are not detailed in the available data. These findings contribute to understanding the feasibility of implementing such an intervention to improve care coordination and adherence for people living with HIV transitioning out of hospital care.
Source
The information regarding these trial results was obtained from ClinicalTrials.gov, a public database of clinical studies. The results for the study NCT05694546, titled "Re-engagement at Discharge 2", were posted on 2025-08-07 on clinicaltrials.gov.