Trial results for an intervention addressing the continuum of care for HIV/AIDS and STDs among high-risk Thai men were posted on ClinicalTrials.gov on 2025-12-08, with 636 participants enrolled.
Background
Young Thai men who have sex with men (YMSM) face a high risk of HIV infection. Existing national HIV strategies in Thailand have been noted for their one-size-fits-all approach, potentially overlooking specific prevention needs relevant to YMSM. Addressing this gap is crucial for effective public health interventions. This study aimed to develop, implement, and evaluate a tailored, multicomponent, multi-level, community mobilization, combination intervention (HUG-M+) designed to improve the entire continuum of HIV prevention and care for this population.
Trial design
This completed study, designated as Phase NA, enrolled 636 participants. The trial focused on conditions including HIV/AIDS and STD among young Thai men who have sex with men. The study evaluated a multicomponent, multi-level, community mobilization, combination intervention (HUG-M+) against a Standard of Care approach, aiming to address the Continuum of Prevention and Care.
Key results
The trial reported several key measurements related to HIV testing and sexual behavior:
- Prevalence of HIV Testing in the Past 6 Months Among YMSM:
- At baseline, 92 participants in the Mpowerment-based Intervention group and 48 participants in the Standard of Care group reported HIV testing.
- At 6 months, 114 participants in the Mpowerment-based Intervention group and 80 participants in the Standard of Care group reported HIV testing.
- At 12 months, 104 participants in the Mpowerment-based Intervention group and 98 participants in the Standard of Care group reported HIV testing.
- At 18 months, 96 participants in the Mpowerment-based Intervention group and 96 participants in the Standard of Care group reported HIV testing.
- At 24 months, 61 participants in the Mpowerment-based Intervention group and 77 participants in the Standard of Care group reported HIV testing.
- Prevalence of Condomless Anal Sex in the Past 6 Months Among YMSM at Baseline:
- 56 participants in the Mpowerment-based Intervention group and 63 participants in the Standard of Care group reported condomless anal sex.
What this means
The posted results provide observed counts for HIV testing prevalence and condomless anal sex among young Thai men who have sex with men over a 24-month period. Initially, the Mpowerment-based Intervention group showed higher rates of HIV testing compared to the Standard of Care group, particularly at 6 and 12 months. However, by 24 months, the prevalence of HIV testing in the intervention group was lower than in the standard of care group. At baseline, the intervention group also reported a lower prevalence of condomless anal sex. These measurements contribute to understanding the behavioral outcomes associated with the HUG-M+ intervention in this high-risk population, informing future public health strategies.
Source
The information regarding these trial results was obtained from ClinicalTrials.gov, a public database of clinical studies. The results for the study NCT05161689, titled "Addressing the Continuum of Care Among High-risk Thai Men", were posted on 2025-12-08 on clinicaltrials.gov.