Trial results for a study investigating a novel Data-to-Suppression (D2S) intervention strategy for HIV were posted on ClinicalTrials.gov on 2026-03-19. The study reported 309 participants in the D2S intervention group achieved timely viral suppression, compared to 352 in the usual care group.

Background

The Ryan White HIV/AIDS Program (RWHAP) is a critical resource for low-income people with HIV (PWH), playing a key role in reducing HIV health disparities and scaling up evidence-based interventions. As RWHAP serves more than 50% of PWH in the United States, its outcomes are vital for achieving the "getting-to-zero" and Ending the HIV Epidemic (EHE) Plan targets. New York City (NYC), a grantee for RWHAP Part A (RWPA) funding, conducts regular HIV care continuum monitoring within its RWPA programs, which offer support services to reduce social and behavioral barriers to care and treatment.

Trial design

This study, designated as Phase NA, enrolled 1494 participants to investigate conditions including HIV. The trial examined a novel Data-to-Suppression (D2S) intervention strategy within the Ryan White HIV/AIDS Program. The intervention was compared against usual care, with the aim of improving outcomes related to the HIV care continuum.

Key results

The trial reported key measurements related to timely viral suppression:

What this means

The posted results provide specific participant counts for timely viral suppression in both the D2S intervention group and the usual care group. Without further statistical analysis, such as p-values or confidence intervals, it is not possible to draw conclusions about the comparative effectiveness or superiority of the D2S intervention based solely on these raw numbers. The data contributes to the ongoing monitoring of HIV care continuum outcomes within the Ryan White HIV/AIDS Program.

Source

The information regarding these trial results was obtained from ClinicalTrials.gov, a public database of clinical studies. The results for the study NCT05140421, titled "Testing a Novel Data-to-Suppression (D2S) Intervention Strategy in the Ryan White HIV/AIDS Program", were posted on 2026-03-19 on clinicaltrials.gov.