Trial results for a study evaluating a culturally relevant stigma intervention for women living with HIV in Tanzania were posted on ClinicalTrials.gov on 2025-05-29, with 167 participants enrolled.
Background
HIV-related stigma remains a significant barrier to care, treatment adherence, and overall well-being for individuals living with HIV, particularly for women in various global settings. Addressing social stigma is crucial for improving the quality of life, self-efficacy, self-esteem, and hope among affected populations. Culturally relevant interventions are designed to resonate with specific community contexts, aiming for greater effectiveness in reducing the pervasive impact of stigma. This study aimed to test such an intervention among women living with HIV in Tanzania.
Trial design
This completed study, designated as Phase NA, enrolled 167 participants to investigate conditions including HIV, Social Stigma, Self Efficacy, Self Esteem, and Hope. The trial tested a culturally relevant stigma reduction intervention with women living with HIV in Tanzania, comparing it against a Treatment as Usual Group.
Key results
The trial reported several key measurements related to participant recruitment, retention, and data completeness:
- Participant recruitment: 87 participants were recruited into the Stigma Intervention Group, and 80 into the Treatment as Usual Group, totaling 167 participants.
- Participant retention: Retention numbers varied across different measurement points. Examples include 77 participants retained in both the Treatment as Usual and Stigma Intervention groups at one point, and 79 in the Treatment as Usual group versus 76 in the Stigma Intervention group at another.
- Data completeness: 0 percent of questions were left blank on study instruments for both the Treatment as Usual Group and the Stigma Intervention Group.
Key analyses using Mixed Models Analysis reported several statistically significant findings:
- A slope of -0.41 with a p-value of 0.0001.
- A slope of 0.002 with a p-value of 0.0001.
- A slope of 0.06 with a p-value of 0.002.
- A slope of -0.0003 with a p-value of 0.01.
- A slope of 0.05 with a p-value of 0.001.
- A slope of -0.0002 with a p-value of 0.032.
What this means
The posted results indicate that the culturally relevant stigma intervention for women living with HIV in Tanzania produced statistically significant changes in several measured parameters, as evidenced by the reported slopes and associated p-values from the mixed models analysis. While the specific outcomes corresponding to these slopes are not detailed in the available data, the consistent statistical significance suggests a measurable effect of the intervention. High participant retention and data completeness further support the feasibility and successful implementation of the study.
Source
The information regarding these trial results was obtained from ClinicalTrials.gov, a public database of clinical studies. The results for the study NCT05033002, titled "Efficacy Testing of a Culturally Relevant Stigma Intervention With WLWH in Tanzania", were posted on 2025-05-29 on clinicaltrials.gov.