Trial results for the iTransition development study, investigating support for youth living with HIV transitioning to adult care, were posted on ClinicalTrials.gov on 2025-08-13. The study enrolled 78 participants.
Background
Youth living with Human Immunodeficiency Virus (HIV) face a critical challenge when transitioning from pediatric to adult healthcare. This period is associated with a high risk of disengagement from care, which can lead to poorer health outcomes. Addressing this gap requires innovative solutions that support both patients and their clinical providers through the transition process. The iTransition study aimed to develop a mobile application designed to facilitate this navigation, thereby improving care continuity for this vulnerable population.
Trial design
This completed study, designated as Phase NA, enrolled 78 participants. The conditions investigated included Human Immunodeficiency Virus and HIV Seropositivity. The trial explored the development of a mobile app, referred to as iTransition, intended to assist youth living with HIV and their providers in navigating the transition from pediatric to adult care. Key measurements compared outcomes between a Youth Living with HIV (YLH) iTransition Intervention Group and a YLH Historical Control Group.
Key results
The trial reported key measurements related to linkage to adult care and care retention:
- Linkage to Adult Care:
- The YLH Historical Control Group reported 16 Participants.
- The YLH iTransition Intervention Group reported 22 Participants.
- Care Retention Per Each 6-month Period (first measurement):
- The YLH Historical Control Group reported 17 Participants.
- The YLH iTransition Intervention Group reported 27 Participants.
- Care Retention Per Each 6-month Period (second measurement):
- The YLH Historical Control Group reported 14 Participants.
- The YLH iTransition Intervention Group reported 31 Participants.
- Care Retention Per Each 6-month Period (third measurement):
- The YLH Historical Control Group reported 14 Participants.
- The YLH iTransition Intervention Group reported 31 Participants.
What this means
The posted results suggest that the iTransition mobile app may positively impact care outcomes for youth living with HIV during their transition to adult care. The intervention group showed a higher number of participants achieving linkage to adult care and demonstrated improved care retention over multiple 6-month periods compared to the historical control group. While these findings indicate a beneficial trend, the data provided does not include statistical analyses, so further research with robust statistical evaluation would be valuable to confirm the app's efficacy and inform clinical practice.
Source
The information regarding these trial results was obtained from ClinicalTrials.gov, a public database of clinical studies. The results for the study NCT04383223, titled "iTransition Development", were posted on 2025-08-13 on clinicaltrials.gov.