Trial results for a study investigating a functional interval training program for Veterans living with HIV were posted on ClinicalTrials.gov on 2026-01-07. The study reported a mean change in VO2peak of 0.09 Liters/minute for the exercise intervention group after 12 weeks.
Background
Most Veterans living with HIV are 50 years of age or older and, with current medication, can expect to live more than 20 years longer. Despite this success, Veterans living with HIV often experience age-related diseases and a loss of fitness and muscle, which increases their risk for disability. Addressing these issues is a major priority for the VHA, which is the largest provider of HIV care in the United States. This study aimed to test a circuit exercise program, designed to slow down the aging process, that could be widely available via video telehealth.
Trial design
This completed study, designated as Phase NA, enrolled 89 participants diagnosed with HIV Infection. The trial investigated a circuit exercise program delivered through telehealth, comparing an exercise group to a control group. The primary goal was to test the effectiveness of this program in slowing the aging process among Veterans living with HIV.
Key results
The trial reported several key measurements for the outcome "Change From Baseline VO2peak to After 12-week Exercise Intervention":
- For the Exercise Group:
- A mean value of 1.99 Liters/minute (Standard Deviation 0.46) was reported.
- Another mean value of 2.07 Liters/minute (Standard Deviation 0.53) was reported.
- A mean value of 0.09 Liters/minute (Standard Deviation 0.23) was reported.
- For the Control Group:
- A mean value of 2.05 Liters/minute (Standard Deviation 0.57) was reported.
- Another mean value of 2.07 Liters/minute (Standard Deviation 0.47) was reported.
- A mean value of 0.00 Liters/minute (Standard Deviation 0.29) was reported.
What this means
The results from this telehealth-delivered exercise intervention suggest a potential benefit for Veterans living with HIV. The exercise group showed a mean increase of 0.09 Liters/minute in VO2peak after 12 weeks, while the control group showed no mean change. This indicates that a functional interval training program, accessible via telehealth, could contribute to improved fitness in this population, potentially mitigating age-related decline. However, without statistical analyses or p-values, the significance of these observed changes cannot be fully determined, and further research would be needed to confirm these preliminary findings.
Source
The information regarding these trial results was obtained from ClinicalTrials.gov, a public database of clinical studies. The results for the study NCT04103593, titled "Functional Interval Training for Veterans Exercising Through Telehealth", were posted on 2026-01-07 on clinicaltrials.gov.