Trial results for a study investigating HIV prevention services among young women were posted on ClinicalTrials.gov on 2025-07-15, with 60 participants enrolled.
Background
HIV remains a significant global health challenge, particularly among young women in high-risk settings. Pre-exposure prophylaxis (PrEP) is a highly effective prevention method for individuals at substantial risk of acquiring HIV. However, the effectiveness of PrEP relies heavily on consistent uptake and adherence. Addressing barriers to PrEP initiation and adherence, along with promoting regular HIV testing, is crucial for reducing new HIV infections in vulnerable populations. This study focused on young women aged 15-24 in Kampala, Uganda, a demographic identified as very high risk, aiming to enhance the delivery and effectiveness of HIV prevention services.
Trial design
This completed study, designated as Phase NA, enrolled 60 participants to investigate conditions related to HIV/AIDS. The trial aimed to develop and assess an intervention to enhance initiation and adherence to PrEP among HIV-negative young women of high risk (YWHR) aged 15-24 in Kampala, Uganda. The study included an intervention group and a comparison group to evaluate the impact of the developed prevention intervention.
Key results
The trial reported key measurements related to PrEP initiation and adherence:
- Initiation of PrEP:
- In the Intervention group, 18 participants initiated PrEP.
- In the Comparison group, 21 participants initiated PrEP.
- Adherence to PrEP:
- In the Intervention group, 19 participants demonstrated adherence to PrEP.
- In the Comparison group, 18 participants demonstrated adherence to PrEP.
What this means
The posted results provide specific participant counts for PrEP initiation and adherence within both the intervention and comparison groups. These figures offer insights into the observed rates of uptake and consistent use of PrEP among young, high-risk women in Kampala, Uganda, within the context of the study's design. This data can inform public health strategies and future research efforts aimed at improving HIV prevention service delivery and PrEP adherence in similar vulnerable populations.
Source
The information regarding these trial results was obtained from ClinicalTrials.gov, a public database of clinical studies. The results for the study NCT04030520, titled "Improving Uptake and Adherence to HIV Prevention Services With Pre-exposure Prophylaxis (PrEP), HIV Self- Testing and Adherence Support for Very High Risk HIV-negative Young Women Aged 15-24 in Kampala, Uganda", were posted on 2025-07-15 on clinicaltrials.gov.