Trial results for an integrated bio-behavioral primary HIV prevention intervention among high-risk people who use drugs were posted on ClinicalTrials.gov on 2025-08-17. The CHRP-BB experimental condition showed a mean PrEP adherence behavior score of 25.9 compared to 22.8 in the active control group.

Background

HIV remains a significant public health challenge, particularly among high-risk populations such as people who use drugs (PWUD). Preventing new infections relies on effective strategies, including pre-exposure prophylaxis (PrEP) and behavioral interventions to reduce risk. Adherence to PrEP is crucial for its efficacy, and integrated approaches addressing both biological and behavioral factors are vital for improving outcomes in vulnerable groups.

Trial design

This completed study enrolled 237 participants to evaluate an integrated bio-behavioral primary HIV prevention intervention. The trial focused on conditions including Risk Behavior, HIV/AIDS, Medication Adherence, and Substance Abuse. The experimental intervention, CHRP-BB, was described as an integrated bio-behavioral approach incorporating PrEP use with an evidence-based behavioral approach aimed at enhancing PrEP adherence and HIV risk reduction. It was compared against an active control condition, which was an evidence-based behavioral approach.

Key results

The trial reported on two key behavioral outcomes:

What this means

The results indicate that the integrated bio-behavioral CHRP-BB intervention was associated with numerically higher mean scores for both PrEP adherence behavior and HIV risk reduction behavior compared to the active control. While specific statistical analyses were not provided, these findings suggest that comprehensive, integrated approaches may offer benefits in improving critical behaviors for HIV prevention among high-risk populations, such as people who use drugs. Enhanced PrEP adherence and reduced risk behaviors are crucial for curbing HIV transmission.

Source

The information for these trial results was obtained from ClinicalTrials.gov, a public database of clinical studies. The results for the study NCT03282890, titled "Testing an Integrated Bio-Behavioral Primary HIV Prevention Intervention Among High-Risk People Who Use Drugs", were posted on 2025-08-17 on clinicaltrials.gov.