Trial results for a study on secondary HIV prevention and adherence among HIV-infected drug users were posted on ClinicalTrials.gov on 2025-08-08. The study enrolled 106 participants to compare two intervention programs, 3H+ (Holistic Health for HIV) and HHRP+ (Holistic Health Recovery Program).
Background
HIV remains a significant global health challenge, with ongoing efforts focused on both treatment and prevention. A critical component of managing HIV and preventing its transmission is consistent adherence to Antiretroviral Therapy (ART) and the reduction of high-risk behaviors. Programs designed to support medication adherence and address risk behaviors are essential, particularly for populations such as HIV-infected individuals who use drugs. This trial aimed to assess the comparative effectiveness of two holistic health programs in improving ART adherence and reducing HIV risk behaviors.
Trial design
This completed study, designated as Phase NA, enrolled 106 participants. The trial investigated interventions for conditions including Risk Behavior, Medication Adherence, and HIV. The study's objective was to test whether 3H+ (Holistic Health for HIV) was comparable to the original HHRP+ (Holistic Health Recovery Program) in reducing HIV risk behaviors and improving ART adherence. Participants were HIV-positive individuals in drug treatment who reported unsafe injection drug use practices or sexual risk behavior.
Key results
The study collected key measurements related to ART adherence and viral suppression:
- Number of Participants in Each Condition With Optimal ART Adherence:
- In the 3H+ Group, 27 participants achieved optimal ART adherence, with a dispersion value of 0.063.
- In the HHRP+ Group, 29 participants achieved optimal ART adherence, with a dispersion value of 0.066.
- Viral Suppression:
- For the Holistic Health for HIV (3H+) group, 45 participants achieved viral suppression, with a dispersion value of 0.048.
- For the Holistic Health Recovery Program (HHRP+) group, 34 participants achieved viral suppression, with a dispersion value of 0.066.
What this means
The results of this comparative effectiveness trial provide insights into the impact of two holistic health programs on HIV management. While the HHRP+ group showed a slightly higher number of participants with optimal ART adherence (29 vs. 27), the 3H+ program demonstrated a notable advantage in achieving viral suppression, with 45 participants reaching this outcome compared to 34 in the HHRP+ group. Viral suppression is a critical indicator of treatment success, improving the health of individuals with HIV and significantly reducing the risk of transmission. These findings suggest that 3H+ may be particularly effective in achieving this key clinical outcome among HIV-infected drug users.
Source
The information regarding these trial results was obtained from ClinicalTrials.gov, a public database of clinical studies. The results for study NCT01741311, titled "Secondary HIV Prevention and Adherence Among HIV-infected Drug Users", were posted on 2025-08-08 on clinicaltrials.gov.