Trial results for the Peer Empowered Endometriosis Pain Support (PEEPS) program, an Endometriosis Group Care intervention for Endometriosis, were posted on ClinicalTrials.gov on 2026-03-06. The trial, which enrolled 35 participants, reported a reduction of -12.58 units in the Endometriosis Health Profile-30 score.
Background
Endometriosis is a chronic condition characterized by the growth of tissue similar to the uterine lining outside the uterus, often leading to significant pelvic pain and reduced quality of life. Managing endometriosis-related pelvic pain can be complex, often requiring a multifaceted approach. The Peer Empowered Endometriosis Pain Support (PEEPS) program was designed to offer a group care intervention, integrating support from an endometriosis specialist, pain psychologist, pelvic floor physical therapist, and yoga instructor. This program aims to address pain interference and improve patient-reported quality of life outcomes by providing comprehensive, multidisciplinary support.
Trial design
This completed study, titled "Endometriosis Group Care," enrolled 35 participants to evaluate the effectiveness of the Peer Empowered Endometriosis Pain Support (PEEPS) program. The trial focused on individuals living with Endometriosis and Pelvic Pain. Participants engaged in eight weekly 2-hour sessions led by an endometriosis specialist, pain psychologist, pelvic floor physical therapist, and yoga instructor. The study aimed to assess if PEEPS is effective at decreasing pain interference and improving patient-reported quality of life outcomes.
Key results
The trial results for the Endometriosis Group Care intervention reported several key measurements:
- PROMIS Pain Interference SF 8a showed a least squares mean of -1.62 t-score with a Standard Error of 1.37.
- PROMIS Physical Function SF10a showed a least squares mean of 1.12 t-score with a Standard Error of 0.98.
- Female Sexual Function Index showed a least squares mean of 1.51 units on a scale with a Standard Error of 1.85.
- Endometriosis Health Profile-30 showed a least squares mean of -12.58 units on a scale with a Standard Error of 3.21.
- PROMIS Anxiety SF7a showed a least squares mean of -1.84 t-score with a Standard Error of 1.35.
- PROMIS Depression SF8b showed a least squares mean of -2.48 T-score with a Standard Error of 1.27.
- Patient Global Impression of Change (PGIC) was reported by 37.5 percentage of participants.
- Modified Every Day Discrimination Scale was reported by 67.6 percentage of participants.
What this means
The results from the Endometriosis Group Care trial suggest potential benefits for individuals with endometriosis-related pelvic pain. The observed least squares mean reduction of -1.62 t-score in PROMIS Pain Interference SF 8a indicates a decrease in pain's impact on daily life. Furthermore, the Endometriosis Health Profile-30 showed a notable reduction of -12.58 units on a scale, suggesting an improvement in overall health-related quality of life. Participants also experienced reductions in psychological distress, with PROMIS Anxiety SF7a decreasing by -1.84 t-score and PROMIS Depression SF8b by -2.48 T-score. Improvements were also seen in PROMIS Physical Function SF10a, which increased by 1.12 t-score, and Female Sexual Function Index, increasing by 1.51 units on a scale. These findings indicate that a multidisciplinary group care program like PEEPS may offer a valuable approach to managing the complex symptoms of endometriosis, addressing both physical and psychological aspects of the condition.
Source
The information regarding these trial results was obtained from ClinicalTrials.gov, a public database of clinical studies. The results for the study NCT05622955, titled "Endometriosis Group Care", were posted on 2026-03-06 on clinicaltrials.gov.