Trial results for a study investigating COVID-19 vaccine confidence among long-term care workers were posted on ClinicalTrials.gov on 2025-08-05, involving 2,634 participants.
Background
COVID-19 has significantly impacted global health, with vaccination being a critical public health measure. Ensuring high vaccine confidence, particularly among frontline healthcare workers such as those in long-term care, is essential for protecting vulnerable populations and maintaining healthcare system resilience. This study aimed to evaluate different online interventions designed to enhance vaccine confidence among this key demographic.
Trial design
The CONFIDENT Study, a completed three-arm randomized trial designated as Phase NA, enrolled 2,634 participants to address COVID-19 vaccine confidence. The study compared two interventions—a Dialogue-Based Webinar and a Social Media Website featuring curated content—against an Enhanced Usual Practice arm, which provided access to the Centers for Disease Control and Prevention (CDC) website. The primary goal was to assess the impact of these online interventions on long-term care workers' confidence in COVID-19 vaccines.
Key results
The trial reported measurements for COVID-19 vaccine confidence and changes from baseline across the three study arms:
- COVID-19 Vaccine Confidence:
- Dialogue-Based Webinar: 93 participants
- Social Media Website: 106 participants
- Enhanced Usual Practice: 138 participants
- Change From Baseline to 3 Weeks Post-randomization in COVID-19 Vaccine Confidence:
- Dialogue-Based Webinar: 42 participants
- Social Media Website: 49 participants
- Enhanced Usual Practice: 62 participants
- Change From Baseline to 3 Months Post-randomization in COVID-19 Vaccine Confidence:
- Dialogue-Based Webinar: 57 participants
- Social Media Website: 58 participants
- Enhanced Usual Practice: 55 participants
- Change From Baseline to 6 Months Post-randomization in COVID-19 Vaccine Confidence:
- Dialogue-Based Webinar: 52 participants
- Social Media Website: 66 participants
- Enhanced Usual Practice: 62 participants
Key analyses, including groupwise binomial comparisons and Fisher Exact tests, indicated no statistically significant differences between the intervention groups regarding vaccine confidence. For instance, p-values for various comparisons were reported as 0.99, 0.98, 0.85, 0.93, 0.9, and 0.83, suggesting that the tested interventions did not significantly alter vaccine confidence compared to the enhanced usual practice.
What this means
The results indicate that the online Dialogue-Based Webinar and Social Media Website interventions, as tested in this study, did not significantly improve COVID-19 vaccine confidence among long-term care workers compared to providing access to standard online information. These findings suggest that alternative or more intensive strategies may be necessary to effectively boost vaccine confidence within this population, or that the impact of such interventions is minimal.
Source
The information regarding these trial results was obtained from ClinicalTrials.gov, a public database of clinical studies. The results for the study NCT05168800, titled "CONFIDENT: Supporting Long-term Care Workers During COVID-19", were posted on 2025-08-05 on clinicaltrials.gov.