Trial results for an observational study investigating symptom-based markers for COVID-19 were posted on ClinicalTrials.gov on 2026-01-26, involving 214 participants and reporting a median body temperature of 98.1 degrees Fahrenheit.
Background
COVID-19, caused by the SARS-CoV-2 virus, presents with a wide range of symptoms that can vary in severity and duration. Understanding the patterns of symptom development and how these symptoms fluctuate throughout the infection period is crucial for disease monitoring and public health response. This study aimed to gather detailed, daily symptom data from infected individuals to further this understanding.
Trial design
This completed observational study enrolled 214 participants diagnosed with COVID-19. The study's objective was to understand COVID-19 symptom development throughout the infection period and how symptoms vary at different points of the day. Participants received daily surveys about their symptoms via a bidirectional texting program.
Key results
The study reported key measurements from COVID-19 positive patients:
- Body Temperature: A median of 98.1 degrees Fahrenheit (Standard Deviation 0.85) was observed.
- Submitted Symptoms: Various counts of submitted symptoms were recorded, including 956, 1532, 1669, 305, 141, 1140, 168, 1096, 388, 747, and 768 individual symptom submissions.
What this means
The posted results contribute to the descriptive understanding of symptom development and variation in COVID-19 positive patients. The collected data on body temperature and the high volume of submitted symptoms offer insights into the daily experiences of individuals with the infection, which can inform future research into symptom-based markers and disease progression.
Source
The information regarding these trial results was obtained from ClinicalTrials.gov, a public database of clinical studies. The results for the study NCT04665245, titled "Symptom-Based Markers for COVID-19 Transmission", were posted on 2026-01-26 on clinicaltrials.gov.