Trial results for a study on promoting informed choice for breast cancer screening were posted on ClinicalTrials.gov on 2025-10-24, involving 637 participants.
Background
Breast cancer screening, primarily through mammography, is a critical component of public health strategies. However, individuals' perceptions and reactions to information regarding the benefits and harms of screening can significantly influence their decision-making and trust in healthcare providers. Understanding factors such as reactance, self-exemption, disbelief, and source derogation is essential for developing effective communication strategies that promote informed choice and address potential barriers to screening adherence. This study aimed to identify the prevalence and predictors of these behavioral responses in the context of mammography.
Trial design
This completed Phase 2 study enrolled 637 participants to investigate factors related to informed choice for Breast Cancer screening. The trial aimed to identify the prevalence and predictors of reactance, self-exemption, disbelief, and source derogation in reaction to evidence about mammography benefits and harms, and their consequences for decision-making and trust.
Key results
The trial reported several key measurements among women aged 39-49 in the United States:
- Reactance (score on a scale):
- A mean score of 2.28 (Standard Deviation 0.71) was observed.
- Another mean score was 2.45 (Standard Deviation 0.75).
- A third mean score was 2.55 (Standard Deviation 0.80).
- Disbelief (score on a scale):
- A mean score of 2.06 (Standard Deviation 0.61) was observed.
- Another mean score was 2.32 (Standard Deviation 0.63).
- A third mean score was 2.41 (Standard Deviation 0.68).
- Source Derogation (score on a scale):
- A mean score of 2.56 (Standard Error 0.09) was observed.
- Self Exemption (score on a scale):
- A mean score of 2.20 (Standard Deviation 0.70) was observed.
- Another mean score was 2.21 (Standard Deviation 0.71).
- A third mean score was 2.32 (Standard Deviation 0.72).
- Screening Intentions (Participants):
- Counts of 286 and 100 participants were reported.
What this means
The posted results offer quantitative insights into various behavioral responses among women aged 39-49 in the United States regarding breast cancer screening information. The reported mean scores for reactance, disbelief, source derogation, and self-exemption, along with participant counts for screening intentions, provide a baseline understanding of how individuals process and react to evidence about mammography. This data can inform the development of targeted communication strategies to enhance informed decision-making and address potential barriers to screening, ultimately aiming to improve public health outcomes related to breast cancer detection.
Source
The information regarding these trial results was obtained from ClinicalTrials.gov, a public database of clinical studies. The results for the study NCT05376241, titled "Promoting Informed Choice for Breast Cancer Screening", were posted on 2025-10-24 on clinicaltrials.gov.