Trial results from a quality control registry investigating targeted intraoperative radiotherapy (IORT) as a boost for breast cancer were posted on ClinicalTrials.gov on 2025-12-12. The registry reported 10 local recurrences among participants receiving the IORT boost.
Background
Breast cancer is a common malignancy, and radiotherapy is a standard component of treatment, often following surgery. Intraoperative radiotherapy (IORT) delivers a single, high dose of radiation to the tumor bed during surgery, aiming to reduce the overall treatment time and potentially improve patient convenience. When used as a boost, IORT targets the area at highest risk of recurrence, followed by external beam radiotherapy (EBRT).
Trial design
This completed quality control registry, titled 'TARGeted Intraoperative radioTherapy With INTRABEAM as a Boost for Breast Cancer - A Quality Control Registry', enrolled 1133 participants. The study focused on patients with Breast Cancer receiving IORT as an anticipated boost with 20 Gy at the applicator surface, followed by external beam radiotherapy (EBRT).
Key results
Key measurements from the IORT Boost group were reported:
- The number of patients with local recurrence was 10 participants.
- The number of participants with chronic higher grade fibrosis after IORT Boost was 132 participants.
What this means
The registry data provides insights into the outcomes following intraoperative radiotherapy used as a boost for breast cancer. The reported 10 local recurrences and 132 cases of chronic higher grade fibrosis offer specific data points for clinicians and researchers evaluating the long-term efficacy and safety profile of this treatment approach in a real-world setting. These figures contribute to the understanding of patient experiences and potential complications associated with IORT as part of a comprehensive breast cancer treatment regimen.
Source
The information for this update was obtained from ClinicalTrials.gov, a public database of clinical studies. The results for study NCT01440010 were posted on 2025-12-12 on clinicaltrials.gov.