A Phase 3 clinical trial comparing Erector Spinae Plane Block and Serratus Anterior Plane Block for post-mastectomy analgesia in Breast Cancer patients reached its primary completion on March 3, 2026, having enrolled 100 participants.
Background
Effective pain management following surgery, such as a Modified Radical Mastectomy for breast cancer, is crucial for patient recovery and well-being. Inadequate pain control can lead to prolonged hospital stays, increased opioid use, and chronic post-surgical pain. Regional anesthetic techniques, like nerve blocks, are increasingly used to provide targeted analgesia, aiming to reduce systemic side effects and improve patient comfort. This trial investigates two specific regional blocks to determine their comparative efficacy and safety profile in this surgical context.
Trial design
The study, identified as Phase 3, is designed to compare two regional anesthetic techniques. It has enrolled 100 adult female participants undergoing Modified Radical Mastectomy for Breast Cancer. Participants are divided into two groups: one receiving an Ultrasound Guided Erector Spinae Plane Block and the other receiving an Ultrasound Guided Serratus Anterior Plane Block. The primary objective is to assess which block provides better analgesic effect and which is safer regarding the induction of pneumothorax and effects on hemodynamics.
Source
The information for this update was sourced from ClinicalTrials.gov, a public database of clinical studies. The record for study NCT06947330, titled "Comparison Between Erector Spinae Plane Block Versus Serratus Anterior Plane Block Regarding Analgesia Post Modified Radical Mastectomy", indicates primary completion on March 3, 2026, and is accessible on clinicaltrials.gov.