A Phase 3 clinical trial investigating radiation dose intensity in Breast Cancer in young women completed its primary data collection on 2025-12-31. The study enrolled 2400 participants to evaluate the impact of an additional radiation boost.
Background
Breast cancer remains a significant health concern, particularly among young women. Radiation therapy is a standard component of treatment, often used to reduce the risk of local recurrence after surgery. Optimizing radiation dose intensity is an ongoing area of research, aiming to improve long-term outcomes such as local control while maintaining acceptable cosmetic results. This trial specifically hypothesized that an additional 10 Gy boost to the tumor bed could increase local control at 10 years from 88% to 93%.
Trial design
This Phase 3 study, titled "Radiation Dose Intensity Study in Breast Cancer in Young Women," completed its primary data collection. It enrolled 2400 participants diagnosed with Breast Cancer. The trial's hypothesis was that an additional 10 Gy boost to the tumor bed would lead to an increase in local control at 10 years from 88% to 93%, while maintaining acceptable cosmetic outcomes.
Source
The information regarding the primary completion of this trial was obtained from ClinicalTrials.gov, a public database of clinical studies. The record for study NCT00212121, titled "Radiation Dose Intensity Study in Breast Cancer in Young Women," noted its primary completion on 2025-12-31 on clinicaltrials.gov.