Trial results for a study characterizing the left atrial substrate in Atrial Fibrillation were posted on ClinicalTrials.gov on 2025-08-19, involving 31 participants.
Background
Atrial fibrillation (AF) is the most common sustained arrhythmia, with increasing prevalence associated with an aging population. Management of AF is challenging, and invasive catheter ablation procedures are increasingly utilized for patients experiencing symptoms refractory to drug therapy. However, the success rates from these procedures can be limited, partly due to an incomplete understanding of the mechanisms involved in arrhythmia propagation. There is significant interest in the role of structural changes within the muscle of the left atrium, particularly the development of scarring, also known as fibrosis.
Trial design
This completed study, designated as Phase NA, enrolled 31 participants to investigate Atrial Fibrillation. The study's objective was to characterize the stable and dynamic left atrial substrate, aiming to improve understanding of mechanisms involved in arrhythmia propagation and the role of structural changes, such as fibrosis, within the left atrium.
Key results
The trial reported key measurements related to defining the normal range of voltage amplitude:
- For the Atrial Fibrillation Group, the mean voltage amplitude was 2.00 mV (Standard Deviation 2.39).
- For the AcQMap Atrial Fibrillation Group, the mean voltage amplitude was 1.92 mV (Standard Deviation 2.37).
What this means
The posted results provide specific measurements for voltage amplitude within the left atrial substrate in patients with Atrial Fibrillation. These data contribute to the characterization of the electrical properties of the atrial muscle, which is important for understanding the mechanisms of arrhythmia propagation. The findings may aid in improving the understanding of structural changes, such as fibrosis, that influence the success rates of procedures like catheter ablation for Atrial Fibrillation.
Source
The information regarding these trial results was obtained from ClinicalTrials.gov, a public database of clinical studies. The results for the study NCT04229472, titled "Characterising the Stable and Dynamic Left Atrial Substrate in Atrial Fibrillation", were posted on 2025-08-19 on clinicaltrials.gov.