Trial results for the Left Atrial Appendage Closure With SentreHeart Lariat® Device in Atrial Fibrillation were posted on 2026-02-06. The study reported successful left atrial appendage closure in 6 out of 9 participants, with 6 participants experiencing adverse events.
Background
Atrial fibrillation (AF) is a common heart rhythm disorder associated with an increased risk of cardioembolic stroke. For many patients with AF, oral anticoagulation is the standard treatment to reduce stroke risk. However, some patients cannot tolerate or have contraindications to long-term oral anticoagulation. In such cases, left atrial appendage (LAA) closure procedures, like those using the SentreHeart Lariat® Device, are explored as an alternative to prevent clot formation and subsequent stroke.
Trial design
This completed study enrolled 9 participants to evaluate left atrial appendage closure using the SentreHeart Lariat® Device. The trial focused on patients with Cardioembolic Stroke and Atrial Fibrillation who were candidates for LAA closure and for whom oral anticoagulation was contraindicated. The objective was to assess the feasibility and safety of the device for LAA closure.
Key results
The trial reported the following key measurements:
- Number of Participants With Successful Stand-Alone Left Atrial Appendage Closure Using SentreHeart Lariat Device: 6 participants.
- Successful LAA Closure Rate: 6 participants.
- Number of Participants With Adverse Events as a Measure of Safety and Tolerability: 6 patients with adverse events.
What this means
The results from this small study indicate that the SentreHeart Lariat® Device achieved successful left atrial appendage closure in 6 out of 9 enrolled participants. This suggests the device's potential for its intended purpose in patients with atrial fibrillation who cannot take oral anticoagulants. However, the finding that 6 participants experienced adverse events highlights important safety considerations that would need further investigation in larger studies.
Source
The information regarding these trial results was obtained from ClinicalTrials.gov, a public database of clinical studies. The results for study NCT02681042, titled "Left Atrial Appendage Closure With SentreHeart Lariat® Device", were posted on 2026-02-06 on clinicaltrials.gov.