Trial results for a study investigating a Technology-Assisted Stepped Care (TASC) intervention for adolescents with Asthma were posted on ClinicalTrials.gov on 2025-09-18, with 72 participants enrolled.
Background
Asthma is a chronic respiratory condition affecting millions, including adolescents. Effective management often relies on consistent adherence to prescribed inhaler medications. However, adherence can be a significant challenge in this age group, leading to suboptimal disease control and increased risk of exacerbations. Interventions that leverage technology to support and improve medication adherence are crucial for enhancing health outcomes in adolescents with asthma.
Trial design
This completed study, designated as Phase NA, enrolled 72 participants to investigate Asthma. The trial aimed to test the preliminary efficacy of a Technology-Assisted Stepped Care (TASC) adherence promotion intervention for adolescents with asthma. Participants were randomized to either the TASC intervention arm or a treatment as usual control arm.
Key results
The trial reported several key measurements:
- Percent Change in Inhaler Adherence Via Electronic Monitoring:
- For the TASC Intervention group, the mean change was 14.05 percent (Standard Deviation 0.30).
- For the Treatment as Usual group, the mean change was 13.43 percent (Standard Deviation 0.22).
- Change in Composite Asthma Severity Index:
- For the TASC Intervention group, the mean change was -0.92 (Standard Deviation 3.09) on a scale.
- For the Treatment as Usual group, the mean change was -0.34 (Standard Deviation 3.2) on a scale.
- Feasibility Questionnaire (TASC Intervention group only):
- The mean score was 4.30 (Standard Deviation 0.50) on a scale.
- Usability: Questionnaire (TASC Intervention group only):
- The mean score was 75.83 (Standard Deviation 13.57) on a scale.
Analyses performed included ANCOVA, with reported p-values of 0.001 and 0.69.
What this means
The posted results provide preliminary data on the impact of a Technology-Assisted Stepped Care intervention on inhaler adherence and asthma severity in adolescents. The TASC intervention group showed a slightly greater mean percent change in inhaler adherence and a larger mean reduction in the composite asthma severity index compared to the treatment as usual group. Additionally, feasibility and usability questionnaire scores for the TASC intervention suggest it was generally well-regarded by participants. These findings contribute to understanding the potential of technology-assisted approaches in improving asthma management for adolescents.
Source
The information regarding these trial results was obtained from ClinicalTrials.gov, a public database of clinical studies. The results for the study NCT04365556, titled "Using Technology-Assisted Stepped Care Intervention to Improve Adherence in Adolescents With Asthma", were posted on 2025-09-18 on clinicaltrials.gov.