Brain Blood Flow and Cerebral Autoregulation Monitoring in Critically Ill Children

Part of paid clinical trials in Madison, Wisconsin.

Sponsor
University of Wisconsin, Madison
Study ID
NCT07613918
Status
Not Yet Recruiting

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Conditions

  • Cardiac Arrest
  • Critical Illness
  • Pediatric Critical Illness
  • Respiratory Failure
  • Traumatic Brain Injury

Eligibility Criteria

Sex
ALL
Age
1 Day - 17 Years
Healthy Volunteers
Not accepted

Interventions

  • Transcranial Doppler — DEVICE
    TCD measurements synchronized to arterial blood pressure and ventilatory data, performed once daily for up to 5 days during PICU admission plus one additional pre-extubation scan if applicable, approximately 30 minutes each. Bilateral middle cerebral artery (MCA) insonation performed at each session.

Study Details

This study uses a non-invasive (external) ultrasound test called Transcranial Doppler (TCD) to measure how blood flows through the major arteries of the brain of children receiving care in the Pediatric Intensive Care Unit (PICU). TCD is already used for clinical reasons in many children, but it is not part of routine monitoring for every critically ill child. By using TCD, the investigators hope to better understand how brain blood flow changes during illness. They will also track children's functional status from before their illness to the time of PICU discharge to explore how brain blood flow patterns relate to neurological outcomes.125 participants will be enrolled and will be on study while in the PICU, estimated to be 3-14 days.

Key Dates

Start date
Jun 30, 2026
Status verified
Jun 2026
Primary completion
May 31, 2028
Completion
May 31, 2028

Study Design

Enrollment
125 participants (estimated)

Arms

  • Arm: PICU Patients
    Mechanically ventilated pediatric patients (1 day-17.5 years) admitted to the PICU.

Primary Outcome Measure

Change in Functional Status Scale (FSS) from baseline to PICU discharge [ Time Frame: Baseline FSS reflects pre-morbid functional status as reported by parents/guardians at enrollment; follow-up FSS assessed at PICU discharge (estimated 3-14 days) ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
American Family Children's Hospital PICUMadisonWisconsin53792
Talal Al Hendawi, MD (SUB_INVESTIGATOR)
Neil Munjal, MD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Madison, WI

By research site
American Family Children's Hospital PICU· Madison, WI

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