Imaging CRF X NOP Interactions in Alcohol Use Disorder

Part of paid clinical trials in Pittsburgh, Pennsylvania.

Sponsor
Rajesh Narendran
Study ID
NCT07612631
Phase
EARLY_PHASE1
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 55 Years
Healthy Volunteers
Accepted

Interventions

  • Baseline [C-11]NOP-1A PET scan — RADIATION
    Radiotracer
  • Hydrocortisone — DRUG
    Intravenous, 1 mg/Kg
  • Post-hydrocortisone [C-11]NOP-1A PET scan — RADIATION
    Radiotracer

Study Details

This positron emission tomography imaging study uses \[C-11\]NOP-1A and hydrocortisone to image stress-modulating proteins in heavy drinking alcohol use disorder (AUD) subjects and healthy controls (HC). It will also characterize the role of these stress-regulating proteins in a relapse to alcohol.

Key Dates

Start date
Jun 1, 2026
Status verified
Jun 2026
Primary completion
Jun 30, 2031
Completion
Jun 30, 2032

Study Design

Enrollment
90 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: PET
    \[C-11\]NOP-1A

Primary Outcome Measure

Amygdala DELTA VT [ Time Frame: Baseline/pre hydrocortisone, and 3-hours post hydrocortisone ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of PittsburghPittsburghPennsylvania15213-

Find similar trials in Pittsburgh, PA

By condition
Substance use disorder
By specialty
Behavioral healthAddiction medicine
By research site
University of Pittsburgh· Pittsburgh, PA

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