The Effects of GLP-1 Receptor Agonists on Chemosensory Function and Ingestive Behavior

Part of paid clinical trials in West Lafayette, Indiana.

Sponsor
Purdue University
Study ID
NCT07611201
Status
Completed

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 65 Years
Healthy Volunteers
Accepted

Study Details

The goal of this study is to explore whether of GLP-1 receptor agonist use is associated with differences in taste, smell, food preferences, appetite, food cravings, and responses to food cues in adults. The study includes adults who are not currently taking a GLP-1 receptor agonist but may be eligible to use one, and adults who are already taking a GLP-1 receptor agonist as part of their regular medical care for approximately 1 month or approximately 6 months. The main questions it aims to answer are: Are taste and smell function different among adults who are not taking a GLP-1 receptor agonist and adults who have been taking one for different lengths of time? Are food preferences, appetite, food cravings, food reward, attention to food cues, and salivary responses to food cues different among these groups? Researchers will compare adults not currently taking a GLP-1 receptor agonist with adults taking a GLP-1 receptor agonist for approximately 1 month or approximately 6 months. The research team will not prescribe, assign, or provide GLP-1 receptor agonist medications. People in the study will attend two in-person study visits, complete taste and smell tests, complete food preference and computer-based tasks, and provide saliva samples during a food cue task. Questionnaires about appetite, cravings, food cues, and eating behavior will be completed at home over approximately 2 weeks.

Key Dates

Start date
Feb 20, 2025
Status verified
May 2026
Primary completion
May 4, 2026
Completion
May 4, 2026

Study Design

Enrollment
90 participants (actual)

Arms

  • Arm: Pre-use / Not Currently Taking GLP-1RA
    Adults who are not currently taking a GLP-1 receptor agonist but may be eligible to use one based on body weight criteria (BMI \> 30). Participants in this group are not assigned to GLP-1 receptor agonist treatment by the study team.
  • Arm: Approximately 1 Month GLP-1RA Use
    Adults who have been taking a GLP-1 receptor agonist as part of their regular medical care for approximately 1 month. GLP-1 receptor agonist use is not assigned, prescribed, or modified by the study team.
  • Arm: Approximately 6 Months GLP-1RA Use
    Adults who have been taking a GLP-1 receptor agonist as part of their regular medical care for approximately 6 months. GLP-1 receptor agonist use is not assigned, prescribed, or modified by the study team.

Primary Outcome Measure

Taste Detection Thresholds [ Time Frame: During study participation, up to 2 weeks ]

Locations (1)

FacilityCityStateZIPSite coordinators
Purdue UniversityWest LafayetteIndiana47906-

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By condition
Obesity / overweight
By specialty
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By research site
Purdue University· West Lafayette, IN

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