Spinal Cord Associative Plasticity in Cerebral Palsy

Part of paid clinical trials in New York, New York.

Sponsor
Columbia University
Study ID
NCT07607665
Status
Recruiting
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Conditions

  • Hemiplegic Cerebral Palsy

Eligibility Criteria

Sex
ALL
Age
18 Years - 80 Years
Healthy Volunteers
Not accepted

Interventions

  • Paired brain and nerve stimulation — DEVICE
    This utilizes pairing of repetitive transcranial magnetic stimulation (rTMS) and peripheral nerve stimulation (rPNS) timed to converge in the cervical spinal cord.

Study Details

Associative plasticity has been used to promote functional recovery from conditions affecting movement. The long term goal of this project is to use electrical stimulation techniques to improve arm and hand function. The goal of this prospective experimental study in adults with hemiplegic cerebral palsy (hCP) is to test the effects of pairing hand motor cortical and median nerve stimulation targeted to induce plasticity in the cervical spinal cord. Based on preliminary data in neurotypical adults, the investigators are testing the effects of this approach in adults with hCP. This study will first verify the present stimulation parameters as sufficient to promote induction of associative plasticity of sensorimotor connections for manual dexterity in adults with hCP. This will be assessed through neurophysiological, biomechanical, and clinical functional outcome measures. Successful pairing showing meaningful improvements in dexterity could then be used as an impetus for a larger study examining the efficacy of SCAP in people with hCP.

Key Dates

Start date
Jun 30, 2026
Status verified
May 2026
Primary completion
May 31, 2031
Completion
May 31, 2032

Study Design

Enrollment
25 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Paired brain and nerve stimulation
    With this session, participants will receive paired motor cortical stimulation and median nerve stimulation at sub-threshold intensities, timed to converge in the cervical spinal cord simultaneously.

Primary Outcome Measure

Size of muscle response to brain stimulation after intervention (percentage) [ Time Frame: 30 minutes after intervention ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Columbia University Irving Medical CenterNew YorkNew York10040
Shaker Dukkipati, MD, PhD
[email protected]
2123046501
Jason Carmel, MD, PhD
[email protected]

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By research site
Columbia University Irving Medical Center· New York, NY

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