Eating Almonds Before a Meal to Control Blood Sugar

Part of paid clinical trials in Baton Rouge, Louisiana.

Sponsor
Pennington Biomedical Research Center
Study ID
NCT07603739
Status
Not Yet Recruiting

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Conditions

  • Glucose Control
  • Nutrition
  • Precision Medicine
  • Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)

Eligibility Criteria

Sex
ALL
Age
25 Years - 50 Years
Healthy Volunteers
Accepted

Interventions

  • Premeal almond ingestion — DIETARY_SUPPLEMENT
    Premeal almond ingestion (18 g; \~100 kcal) 30 minutes prior to meal

Study Details

The goal of this study is to learn whether eating a small serving of almonds before meals can improve blood sugar control in adults who have early signs of problems with blood sugar regulation. The main questions it aims to answer are: 1. Does eating almonds before a meal reduce the rise in blood sugar after eating? 2. Do some people consistently benefit more than others from eating almonds before meals?

Key Dates

Start date
Jun 30, 2026
Status verified
May 2026
Primary completion
Mar 31, 2028
Completion
Jul 31, 2028

Study Design

Enrollment
25 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Randomization Sequence 1
    One of the randomization sequences. Phase 1: MMTT+, MMTT-, MMTT+, MMTT- \| Phase 2: SAD+, SAD-. In Phase 1, MMTT+ refers to a mixed meal tolerance test with premeal almond ingestion (active condition). MMTT- refers to a mixed meal tolerance test without premeal almond ingestion (control condition). In Phase 2, SAD+ refers to the 10-day controlled feeding diet period using a Standard American Diet with thrice daily premeal almond ingestion (active condition). SAD- refers to the 10-day controlled feeding diet period using a Standard American Diet without premeal almond ingestion (control condition).
  • Experimental: Randomization Sequence 2
    One of the randomization sequences. Phase 1: MMTT-, MMTT+, MMTT-, MMTT+ \| Phase 2: SAD+, SAD-. In Phase 1, MMTT+ refers to a mixed meal tolerance test with premeal almond ingestion (active condition). MMTT- refers to a mixed meal tolerance test without premeal almond ingestion (control condition). In Phase 2, SAD+ refers to the 10-day controlled feeding diet period using a Standard American Diet with thrice daily premeal almond ingestion (active condition). SAD- refers to the 10-day controlled feeding diet period using a Standard American Diet without premeal almond ingestion (control condition).
  • Experimental: Randomization Sequence 3
    One of the randomization sequences. Phase 1: MMTT+, MMTT-, MMTT-, MMTT+ \| Phase 2: SAD+, SAD-. In Phase 1, MMTT+ refers to a mixed meal tolerance test with premeal almond ingestion (active condition). MMTT- refers to a mixed meal tolerance test without premeal almond ingestion (control condition). In Phase 2, SAD+ refers to the 10-day controlled feeding diet period using a Standard American Diet with thrice daily premeal almond ingestion (active condition). SAD- refers to the 10-day controlled feeding diet period using a Standard American Diet without premeal almond ingestion (control condition).
  • Experimental: Randomization Sequence 4
    One of the randomization sequences. Phase 1: MMTT-, MMTT+, MMTT+, MMTT- \| Phase 2: SAD+, SAD-. In Phase 1, MMTT+ refers to a mixed meal tolerance test with premeal almond ingestion (active condition). MMTT- refers to a mixed meal tolerance test without premeal almond ingestion (control condition). In Phase 2, SAD+ refers to the 10-day controlled feeding diet period using a Standard American Diet with thrice daily premeal almond ingestion (active condition). SAD- refers to the 10-day controlled feeding diet period using a Standard American Diet without premeal almond ingestion (control condition).
  • Experimental: Randomization Sequence 5
    One of the randomization sequences. Phase 1: MMTT+, MMTT-, MMTT+, MMTT- \| Phase 2: SAD-, SAD+. In Phase 1, MMTT+ refers to a mixed meal tolerance test with premeal almond ingestion (active condition). MMTT- refers to a mixed meal tolerance test without premeal almond ingestion (control condition). In Phase 2, SAD+ refers to the 10-day controlled feeding diet period using a Standard American Diet with thrice daily premeal almond ingestion (active condition). SAD- refers to the 10-day controlled feeding diet period using a Standard American Diet without premeal almond ingestion (control condition).
  • Experimental: Randomization Sequence 6
    One of the randomization sequences. Phase 1: MMTT-, MMTT+, MMTT-, MMTT+ \| Phase 2: SAD-, SAD+. In Phase 1, MMTT+ refers to a mixed meal tolerance test with premeal almond ingestion (active condition). MMTT- refers to a mixed meal tolerance test without premeal almond ingestion (control condition). In Phase 2, SAD+ refers to the 10-day controlled feeding diet period using a Standard American Diet with thrice daily premeal almond ingestion (active condition). SAD- refers to the 10-day controlled feeding diet period using a Standard American Diet without premeal almond ingestion (control condition).
  • Experimental: Randomization Sequence 7
    One of the randomization sequences. Phase 1: MMTT+, MMTT-, MMTT-, MMTT+ \| Phase 2: SAD-, SAD+. In Phase 1, MMTT+ refers to a mixed meal tolerance test with premeal almond ingestion (active condition). MMTT- refers to a mixed meal tolerance test without premeal almond ingestion (control condition). In Phase 2, SAD+ refers to the 10-day controlled feeding diet period using a Standard American Diet with thrice daily premeal almond ingestion (active condition). SAD- refers to the 10-day controlled feeding diet period using a Standard American Diet without premeal almond ingestion (control condition).
  • Experimental: Randomization Sequence 8
    One of the randomization sequences. Phase 1: MMTT-, MMTT+, MMTT+, MMTT-, \| Phase 2: SAD-, SAD+. In Phase 1, MMTT+ refers to a mixed meal tolerance test with premeal almond ingestion (active condition). MMTT- refers to a mixed meal tolerance test without premeal almond ingestion (control condition). In Phase 2, SAD+ refers to the 10-day controlled feeding diet period using a Standard American Diet with thrice daily premeal almond ingestion (active condition). SAD- refers to the 10-day controlled feeding diet period using a Standard American Diet without premeal almond ingestion (control condition).

Primary Outcome Measure

Postprandial glucose assessed during acute meal test [ Time Frame: Days 1-4: -35 minutes, -5 minutes, 15 minutes, 30 minutes, 60 minutes, 90 minutes, 120 minutes, 180 minutes relative to ingestion of premeal almonds at -30 minutes (if applicable) and the mixed meal tolerance test at 0 minutes. ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Pennington Biomedical Research CenterBaton RougeLouisiana70808
Kaja Falkenhain, PhD
[email protected]
225-763-2558

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