Effects of Ketogenic Diet on Alcohol Intoxication

Part of paid clinical trials in Philadelphia, Pennsylvania.

Sponsor
University of Pennsylvania
Study ID
NCT07602270
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
21 Years - 50 Years
Healthy Volunteers
Accepted

Interventions

  • Ketogenic diet — OTHER
    4 week ketogenic diet

Study Details

The research study is being conducted to better understand the effects of ketosis on brain functioning and the acute effects of alcohol. Participants will be asked to undergo \~4 weeks of ketogenic diet intervention. The study involves three lab visits: Lab 1 before starting the diet, Lab 2 after about 2 weeks after starting the diet, and Lab 3 after being on the diet for 4 weeks. All of the labs will include an alcohol tolerance test, and blood draws. Lab 1 and Lab 3 will also include an Magnetic resonance imaging scan. Due to scheduling, study procedures at 2 and 4 weeks may occur +/- 3 days. Magnetic resonance imaging (MRI) of the brain will measure levels of nicotinamide adenine dinucleotide (NAD) (a coenzyme that is important for energy metabolism), lactate (a metabolite produced during energy metabolism), and neurotransmitters glutamate and GABA. Alcohol tolerance will be tested using a dose of alcohol (approximately 4-5 alcohol beverages) to will elevate breath alcohol levels to approximately 0.08% to measure the acute effects of alcohol. Blood samples will be collected to measure varying metabolites.

Key Dates

Start date
May 14, 2026
Status verified
May 2026
Primary completion
May 31, 2029
Completion
May 31, 2030

Study Design

Enrollment
20 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Ketogenic diet
    4 week ketogenic diet intervention

Primary Outcome Measure

Effects of ketogenic diet on cerebral levels of glutamate. [ Time Frame: 4 weeks ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Center for Studies of AddictionPhiladelphiaPennsylvania19104
Timothy Pond, MPH
[email protected]
215-746-1959
Corinde Wiers, Ph.D (PRINCIPAL_INVESTIGATOR)
Cindy Li, Ph.D. (SUB_INVESTIGATOR)

Find similar trials in Philadelphia, PA

By condition
Substance use disorder
By specialty
Behavioral healthAddiction medicine
By research site
Center for Studies of Addiction· Philadelphia, PA

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