Light Therapy to Improve Sleep in TBI: Sleep-active Biomarkers and Glymphatic Function

Part of paid clinical trials in Portland, Oregon.

Sponsor
Oregon Health and Science University
Study ID
NCT07601841
Status
Recruiting
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Conditions

  • Brain Injuries, Traumatic
  • Glymphatic System
  • Inflammation
  • Mitochondrial Dynamics
  • Phototherapy
  • Sleep

Eligibility Criteria

Sex
ALL
Age
18 Years - 89 Years
Healthy Volunteers
Not accepted

Interventions

  • Morning Bright Light Therapy — DEVICE
    Exposure to bright light shortly after waking.
  • Negative Ion Generator Therapy — DEVICE
    Exposure to negative ions shortly after waking.

Study Details

This is a clinical trial designed to examine how improved sleep through morning bright light therapy is improving downstream key physiologic processes related to brain health, i.e., mitochondrial function, systemic inflammation, and glymphatic function. All proposed methodology is already approved in other IRB applications.

Key Dates

Start date
Dec 12, 2025
Status verified
May 2026
Primary completion
Dec 12, 2028
Completion
Sep 30, 2030

Study Design

Enrollment
300 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Morning Bright Light Therapy
    Exposure to bright light in the morning every day for an hour for 4 weeks.
  • Other: Negative Ion Generator Therapy
    Exposure to negative ions in the morning every day for an hour for 4 weeks.

Primary Outcome Measure

Define the profile of blood-based markers of systemic inflammation pre- vs post-MBLT. [ Time Frame: From pre-intervention to end of device use (Approximately 4 weeks). ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Oregon Health and Science UniversityPortlandOregon97239
Jonathan Elliott, PhD
[email protected]
503-220-8262

Find similar trials in Portland, OR

By research site
Oregon Health and Science University· Portland, OR

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