Alternative Splicing Based Prediction of Chemotherapy Response in Gastric Cancer

Part of paid clinical trials in Duarte, California.

Sponsor
City of Hope Medical Center
Study ID
NCT07587229
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Observational study (no intervention) — OTHER
    This is an observational study without assigned interventions. All patients received standard-of-care 5-FU-based adjuvant chemotherapy, and no experimental intervention was performed.

Study Details

This study aims to develop a model to predict response to chemotherapy in gastric cancer using RNA splicing information from tumor tissue. By analyzing genetic patterns and applying machine learning, the study seeks to identify patients who are less likely to benefit from treatment, helping guide clinical decision-making.

Key Dates

Start date
May 1, 2026
Status verified
May 2026
Primary completion
Jan 1, 2027
Completion
Jan 1, 2027

Study Design

Enrollment
329 participants (estimated)

Arms

  • Arm: Responder
    Patients with stage II/III gastric cancer who did not develop recurrence within 3 years after curative surgery following adjuvant chemotherapy.
  • Arm: Non-responder
    Patients with stage II/III gastric cancer who developed recurrence within 3 years after curative surgery following adjuvant chemotherapy.

Primary Outcome Measure

Treatment response based on 3-year recurrence-free survival [ Time Frame: 3 years after surgery ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
City of Hope Medical CenterDuarteCalifornia91016-

Find similar trials in Duarte, CA

By condition
Gastric cancer
By specialty
OncologyGI oncology
By research site
City of Hope Medical Center· Duarte, CA

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