The Effects of Timolol On Healing and Cosmesis of Mohs Scalp Wounds: An Open Label Trial

Part of paid clinical trials in Danville, Pennsylvania.

Sponsor
Geisinger Clinic
Study ID
NCT07583862
Phase
PHASE2
Status
Not Yet Recruiting

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Conditions

  • Mohs Surgery
  • Surgical Wounds

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Topical Timolol — DRUG
    Topical timolol is the active drug that will be compared to placebo in the trial.
  • Normal Saline — DRUG
    Normal saline is the placebo that will be compared to topical timolol in the trial.

Study Details

The goal of this study clinical trial is to learn if topical timolol can accelerate healing and improve the cosmetic appearance of surgical wounds on the scalp following Mohs surgery. It will include Geisinger patients 18 year or older who undergo Mohs surgery of the scalp with planned wound healing by secondary intent. The main questions in aim to answer are: 1. Compare wound healing speed between patients treated with topical timolol and those receiving standard wound care only. 2. Compare cosmetic outcomes using topical timolol and standard wound care. 3. Evaluate the impact of topical timolol on the number of unplanned follow-up visits and calls related to delayed wound healing. Participants will be asked use either topical timolol or use standard wound care to treat their Mohs surgery scalp wound. They will follow-up around 4, 8 and 12 weeks.

Key Dates

Start date
Jul 1, 2026
Status verified
May 2026
Primary completion
Jul 31, 2028
Completion
Mar 31, 2029

Study Design

Enrollment
40 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Active Comparator: Timolol Arm
    This arm will have their wounds treated with topical timolol.
  • Placebo Comparator: Standard of Care Arm
    This arm will have their wounds treated with normal saline/standard of care.

Primary Outcome Measure

Healing At 12 Weeks [ Time Frame: From treatment start to follow up 12 weeks later ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Geisinger Dermatology WoodbineDanvillePennsylvania17821
Michael Woodfin, MD
[email protected]
570-271-8050
Amrit Greene, MD
[email protected]
570-271-8050
Amrit Greene, MD (PRINCIPAL_INVESTIGATOR)

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